Gene Page:ADRA1B

概括?
基因 147
Symbol ADRA1B
Synonyms ADRA1|ALPHA1BAR
Description adrenoceptor alpha 1B
Reference MIM:104220|HGNC:HGNC:278|HPRD：00080|
Gene type protein-coding
Map location 5q33.3
Pascal p-value 0.507
Fetal beta -0.89
eGene 元

数据源中的基因
Gene set name Method of gene set Description Info
ADT:Sun_2012 系统研究抗精神病药及其靶标 A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01718
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.00459
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0483

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 -26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MN1 0.91 0.89
SOBP 0.90 0.94
MPPED1 0.89 0.92
SCUBE1 0.88 0.81
SLA 0.88 0.88
TTC28 0.88 0.87
SATB2 0.88 0.90
NHSL1 0.87 0.70
SLC22A23 0.87 0.87
MYCN 0.87 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SERPINB6 -0.60 -0.76
ACOT13 -0.57 -0.67
HEPN1 -0.57 -0.74
AIFM3 -0.57 -0.74
HSD17B14 -0.57 -0.77
C5orf53 -0.57 -0.72
HLA-F -0.56 -0.73
ALDOC -0.56 -0.67
CLU -0.56 -0.68
TSC22D4 -0.56 -0.76

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IEA -
GO:0004937 alpha1-adrenergic receptor activity TAS 1328250
GO:0004935 adrenoceptor活性 IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0001987 vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure IEA -
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IEA -
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA -
GO:0001975 response to amphetamine IEA -
GO:0001974 blood vessel remodeling IEA -
GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger TAS 10820200
GO:0007186 G蛋白偶联受体蛋白信号通路 TAS 2154750
GO:0016049 cell growth IEA -
GO:0007267 cell-cell signaling TAS 1328250
GO:0007243 protein kinase cascade TAS 10820200
GO:0007165 signal transduction IEA -
GO:0008283 cell proliferation TAS 10820200
GO:0008542 视觉学习 IEA -
GO:0007512 adult heart development IEA -
GO:0007626 运动的行为 IEA -
GO:0007275 multicellular organismal development TAS 10820200
GO:0042593 葡萄糖稳态 IEA -
GO:0035265 organ growth IEA -
GO:0043278 response to morphine IEA -
GO:0048148 对可卡因的行为反应 IEA -
GO:0045819 positive regulation of glycogen catabolic process IEA -
GO:0045818 negative regulation of glycogen catabolic process IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000299 膜分数的膜不可或缺 IEA -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 1328250

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 该途径中的所有SZGR 2.0基因
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 该途径中的所有SZGR 2.0基因
kegg血管平滑肌收缩 115 81 该途径中的所有SZGR 2.0基因
PID溶物磷脂途径 66 53 该途径中的所有SZGR 2.0基因
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 该途径中的所有SZGR 2.0基因
REACTOME SIGNALING BY GPCR 920 449 该途径中的所有SZGR 2.0基因
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 该途径中的所有SZGR 2.0基因
REACTOME AMINE LIGAND BINDING RECEPTORS 38 33 该途径中的所有SZGR 2.0基因
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 该途径中的所有SZGR 2.0基因
REACTOME G ALPHA1213 SIGNALLING EVENTS 74 56 该途径中的所有SZGR 2.0基因
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 该途径中的所有SZGR 2.0基因
REACTOME GPCR LIGAND BINDING 408 246 该途径中的所有SZGR 2.0基因
PETRETTO HEART MASS QTL CIS UP 28 15 该途径中的所有SZGR 2.0基因
BANDRES RESPONSE TO CARMUSTIN MGMT 24HR DN 33 21 该途径中的所有SZGR 2.0基因
Bandres对Carmustin没有MGMT 48小时DN的响应 32 25 该途径中的所有SZGR 2.0基因
SEMENZA HIF1 TARGETS 36 32 该途径中的所有SZGR 2.0基因
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161 105 该途径中的所有SZGR 2.0基因
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274 165 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME2 491 319 该途径中的所有SZGR 2.0基因
DANG MYC TARGETS UP 143 100 该途径中的所有SZGR 2.0基因
DANG BOUND BY MYC 1103 714 该途径中的所有SZGR 2.0基因
OHGUCHI LIVER HNF4A TARGETS DN 149 85 该途径中的所有SZGR 2.0基因
SERVITJA LIVER HNF1A TARGETS DN 157 105 该途径中的所有SZGR 2.0基因
FORTSCHEGGER PHF8 TARGETS DN 784 464 该途径中的所有SZGR 2.0基因
PEDRIOLI MIR31 TARGETS UP 221 120 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-22 141 147 m8 hsa-miR-22brain AAGCUGCCAGUUGAAGAACUGU