Gene Page:ADRA1A

Summary?
GeneID 148
Symbol ADRA1A
Synonyms ADRA1C|ADRA1L1|ALPHA1AAR
Description adrenoceptor alpha 1A
Reference MIM:104221|HGNC:HGNC:277|Ensembl:ENSG00000120907|HPRD:00081|Vega:OTTHUMG00000099459
Gene type protein-coding
Map location 8p21.2
Pascal p-value 0.116
Fetal beta -1.316
DMG 1 (# studies)
Support GPCR SIGNALLING

Gene in Data Sources
Gene set name Method of gene set Description Info
ADT:Sun_2012 Systematic Investigation of Antipsychotic Drugs and Their Targets A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
GSMA_I Genome scan meta-analysis Psr: 0.031
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.03086
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.00057
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg00460235 8 26723946 ADRA1A 2.16E-8 -0.012 7.31E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C12orf34 0.72 0.69
SOX8 0.66 0.67
PLEKHG3 0.65 0.65
KCNJ2 0.65 0.48
SH3RF2 0.65 0.58
DACT2 0.62 0.37
SLC35D3 0.61 0.34
MME 0.60 0.24
PRIMA1 0.60 0.66
GPR149 0.59 0.37
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GPM6A -0.32 -0.44
GPR22 -0.31 -0.43
EMID1 -0.31 -0.41
EMX1 -0.31 -0.42
MPPED1 -0.31 -0.44
DPP4 -0.30 -0.42
ZNF238 -0.30 -0.39
SNX7 -0.30 -0.44
ULBP2 -0.29 -0.38
NEUROD6 -0.29 -0.49

Section III. Gene Ontology annotation

Molecular function 去你rm Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IEA -
GO:0004937 alpha1-adrenergic receptor activity NAS 9490024
GO:0004937 alpha1-adrenergic receptor activity TAS 7737411
GO:0004935 adrenoceptor activity IEA -
Biological process 去你rm Evidence Neuro keywords PubMed ID
GO:0007186 G-protein coupled receptor protein signaling pathway TAS 10860850
GO:0007267 cell-cell signaling TAS 8396931
GO:0007243 protein kinase cascade TAS 10671514
GO:0007165 signal transduction TAS 8396931
GO:0008285 negative regulation of cell proliferation TAS 10860850
GO:0006939 平滑肌收缩 TAS 8183249
GO:0006915 apoptosis TAS 10671514
Cellular component 去你rm Evidence Neuro keywords PubMed ID
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 8396931

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS 38 33 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 74 56 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390 236 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER 49 29 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 74 51 All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14 DELETION UP 74 40 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 69 48 All SZGR 2.0 genes in this pathway
GYORFFY MITOXANTRONE RESISTANCE 57 35 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway