Gene Page:CTBP1

Summary?
GeneID 1487
Symbol CTBP1
Synonyms BARS
Description C-terminal binding protein 1
Reference MIM:602618|HGNC:HGNC:2494|Ensembl:ENSG00000159692|HPRD:04015|Vega:OTTHUMG00000089259
Gene type protein-coding
Map location 4p16
Pascal p-value 0.026
Fetal beta -0.458
DMG 2 (# studies)
eGene Myers' cis & trans
Meta
Support PROTEIN CLUSTERING
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search 系统搜索PubMed的基因s co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg01942790 4 1211419 CTBP1 1.473E-4 0.581 0.031 DMG:Wockner_2014
cg13216910 4 1242411 CTBP1 1.03E-8 -0.02 4.45E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17799628 chr9 106442995 CTBP1 1487 0.2 trans
rs6128541 chr20 57917688 CTBP1 1487 0.15 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ACTL6B ACTL6 | BAF53B actin-like 6B - HPRD,BioGRID 12565893
APC BTPS2 | DP2 | DP2.5 | DP3 | GS adenomatous polyposis coli CtBP interacts with APC. BIND 15525529
BRCA1 BRCAI | BRCC1 | IRIS | PSCP | RNF53 breast cancer 1, early onset - HPRD,BioGRID 10196224
CBX4 NBP16 | PC2 | hPC2 chromobox homolog 4 (Pc class homolog, Drosophila) Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid		 BioGRID 9858600|11583618
|12679040|12829790
CBX4 NBP16 | PC2 | hPC2 chromobox homolog 4 (Pc class homolog, Drosophila) Pc2 interacts with CtBP1. BIND 15592428
CREBBP CBP | KAT3A | RSTS CREB binding protein CTBP1 interacts with CREBBP (CBP) BIND 15834423
CTBP1 BARS | MGC104684 C-terminal binding protein 1 CTBP1 forms a homodimer BIND 15834423
CTBP2 - C-terminal binding protein 2 - HPRD,BioGRID 9858600
ELAC2 ELC2 | FLJ10530 | FLJ36693 | FLJ42848 | HPC2 elaC homolog 2 (E. coli) - HPRD 9858600
ELK3 ERP | NET | SAP2 ELK3, ETS-domain protein (SRF accessory protein 2) - HPRD 10369679
EP300 KAT3B | p300 E1A binding protein p300 CTBP1 interacts with EP300 (p300) BIND 15834423
EVI1 AML1-EVI-1 | EVI-1 | MDS1-EVI1 | MGC163392 | PRDM3 ecotropic viral integration site 1 - HPRD,BioGRID 11313276
FOXP1 12CC4 | FLJ23741 | HSPC215 | MGC12942 | MGC88572 | MGC99551 | QRF1 | hFKH1B forkhead box P1 - HPRD,BioGRID 14701752
FOXP2 CAGH44 | DKFZp686H1726 | SPCH1 | TNRC10 forkhead box P2 Affinity Capture-Western
Two-hybrid		 BioGRID 14701752
GTF2B TF2B | TFIIB general transcription factor IIB Reconstituted Complex BioGRID 11959865
HDAC1 DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 histone deacetylase 1 - HPRD,BioGRID 9650586
HDAC2 RPD3 | YAF1 histone deacetylase 2 - HPRD,BioGRID 10766745
HDAC3 HD3 | RPD3 | RPD3-2 histone deacetylase 3 Reconstituted Complex BioGRID 11022042
HDAC4 HA6116 | HD4 | HDAC-A | HDACA | KIAA0288 histone deacetylase 4 Reconstituted Complex BioGRID 11022042
HDAC5 FLJ90614 | HD5 | NY-CO-9 histone deacetylase 5 Reconstituted Complex BioGRID 11022042
HDAC9 DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITR histone deacetylase 9 in vitro
in vivo
Reconstituted Complex
Two-hybrid		 BioGRID 11022042
HIC1 ZBTB29 | hic-1 hypermethylated in cancer 1 - HPRD 12052894
HTT 高清| IT15 huntingtin Huntingtin interacts with CTBP. BIND 11739372
HTT 高清| IT15 huntingtin - HPRD,BioGRID 11739372
IKZF1 Hs.54452 | IK1 | IKAROS | LYF1 | PRO0758 | ZNFN1A1 | hIk-1 IKAROS family zinc finger 1 (Ikaros) - HPRD,BioGRID 10766745
IKZF4 EOS | KIAA1782 | ZNFN1A4 IKAROS family zinc finger 4 (Eos) - HPRD,BioGRID 12444977
KAT2B CAF | P | P/CAF | PCAF K(lysine) acetyltransferase 2B CTBP1 interacts with PCAF BIND 15834423
KAT2B CAF | P | P/CAF | PCAF K(lysine) acetyltransferase 2B Biochemical Activity BioGRID 9824164
KLF12 AP-2rep | AP2REP | HSPC122 Kruppel-like factor 12 - HPRD 11373277
MDM2 HDMX | MGC71221 | hdm2 Mdm2 p53 binding protein homolog (mouse) Affinity Capture-Western
Far Western		 BioGRID 12867035
MLL ALL-1 | CXXC7 | FLJ11783 | HRX | HTRX1 | KMT2A | MLL/GAS7 | MLL1A | TET1-MLL | TRX1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) Affinity Capture-Western
Reconstituted Complex		 BioGRID 12829790
NRIP1 FLJ77253 | RIP140 nuclear receptor interacting protein 1 Reconstituted Complex BioGRID 15060175
NRIP1 FLJ77253 | RIP140 nuclear receptor interacting protein 1 - HPRD 11509661
PNN DRS | SDK3 | memA | pinin pinin, desmosome associated protein - HPRD,BioGRID 15542832
RB1 OSRC | RB | p105-Rb | pRb | pp110 retinoblastoma 1 - HPRD 11583618
RBBP8 CTIP | RIM retinoblastoma binding protein 8 - HPRD 9535825|11313276
RBBP8 CTIP | RIM retinoblastoma binding protein 8 Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		 BioGRID 9535825|10196224
SIN3A DKFZp434K2235 | FLJ90319 | KIAA0700 SIN3 homolog A, transcription regulator (yeast) in vivo BioGRID 10766745
SIP1 GEMIN2 | SIP1-delta survival of motor neuron protein interacting protein 1 Affinity Capture-Western BioGRID 12714599
SMAD6 HsT17432 | MADH6 | MADH7 SMAD family member 6 Affinity Capture-Western BioGRID 14645520
TBP GTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIID TATA box binding protein Reconstituted Complex BioGRID 11959865
TCF7L2 TCF-4 | TCF4 transcription factor 7-like 2 (T-cell specific, HMG-box) CtBP does not interacts with TCF-4 in mammalian cells. BIND 15525529
TGIF1 HPE4 | MGC39747 | MGC5066 | TGIF TGFB-induced factor homeobox 1 - HPRD,BioGRID 10995736
ZEB1 AREB6 | BZP | DELTA-EF1 | MGC133261 | NIL-2-A |倪L-2A | NIL2A | TCF8 | ZEB | ZFHEP | ZFHX1A zinc finger E-box binding homeobox 1 Affinity Capture-Western BioGRID 10359772
ZFPM2 DIH3 | FOG2 | MGC129663 | MGC129664 | ZNF89B | hFOG-2 zinc finger protein, multitype 2 - HPRD,BioGRID 10438528


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG WNT SIGNALING PATHWAY 151 112 All SZGR 2.0 genes in this pathway
KEGG NOTCH SIGNALING PATHWAY 47 35 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA 73 59 All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY 26 24 All SZGR 2.0 genes in this pathway
WNT SIGNALING 89 71 All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 82 63 All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY 59 49 All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY 46 39 All SZGR 2.0 genes in this pathway
PID ATM PATHWAY 34 25 All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 80 60 All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 65 46 All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 48 39 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP 177 113 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC 44 31 All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 101 73 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 147 87 All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN DN 19 14 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN 76 57 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 128 90 All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP 203 135 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN 102 65 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway