Gene Page:CTSB

Summary?
GeneID 1508
Symbol CTSB
Synonyms APPS|CPSB
Description cathepsin B
Reference MIM:116810|HGNC:HGNC:2527|Ensembl:ENSG00000164733|HPRD:00287|Vega:OTTHUMG00000090799
Gene type protein-coding
Map location 8p22
Pascal p-value 0.007
Sherlock p-value 0.697
DMG 2 (# studies)
eGene Caudate basal ganglia
Cerebellum
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.1211

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg02637136 8 11725599 CTSB 1.704E-4 -0.349 0.033 DMG:Wockner_2014
cg18787975 8 11726094 CTSB 8.74E-8 -0.012 2.01E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
snp_a-1856993 0 CTSB 1508 0.2 trans
rs35558975 8 11584476 CTSB ENSG00000164733.16 1.123E-6 0 142481 gtex_brain_putamen_basal
rs1736065 8 11685453 CTSB ENSG00000164733.16 5.745E-7 0 41504 gtex_brain_putamen_basal
rs144275726 8 11685801 CTSB ENSG00000164733.16 1.2E-6 0 41156 gtex_brain_putamen_basal
rs1293316 8 11690915 CTSB ENSG00000164733.16 5.838E-7 0 36042 gtex_brain_putamen_basal
rs6990033 8 11693378 CTSB ENSG00000164733.16 2.796E-7 0 33579 gtex_brain_putamen_basal
rs1293325 8 11693577 CTSB ENSG00000164733.16 5.838E-7 0 33380 gtex_brain_putamen_basal
rs1293326 8 11694765 CTSB ENSG00000164733.16 5.838E-7 0 32192 gtex_brain_putamen_basal
rs1293327 8 11694986 CTSB ENSG00000164733.16 4.256E-7 0 31971 gtex_brain_putamen_basal
rs1293328 8 11695060 CTSB ENSG00000164733.16 5.838E-7 0 31897 gtex_brain_putamen_basal
rs1296026 8 11697442 CTSB ENSG00000164733.16 5.025E-7 0 29515 gtex_brain_putamen_basal
rs1293331 8 11698436 CTSB ENSG00000164733.16 5.102E-7 0 28521 gtex_brain_putamen_basal
rs1296028 8 11698747 CTSB ENSG00000164733.16 5.838E-7 0 28210 gtex_brain_putamen_basal
rs1613883 8 11699632 CTSB ENSG00000164733.16 5.756E-7 0 27325 gtex_brain_putamen_basal
rs1692821 8 11699988 CTSB ENSG00000164733.16 7.886E-7 0 26969 gtex_brain_putamen_basal
rs2740592 8 11701253 CTSB ENSG00000164733.16 5.102E-7 0 25704 gtex_brain_putamen_basal
rs2645425 8 11701278 CTSB ENSG00000164733.16 5.114E-7 0 25679 gtex_brain_putamen_basal
rs4839 8 11701933 CTSB ENSG00000164733.16 5.102E-7 0 25024 gtex_brain_putamen_basal
rs3947 8 11702375 CTSB ENSG00000164733.16 5.154E-7 0 24582 gtex_brain_putamen_basal
rs709821 8 11702594 CTSB ENSG00000164733.16 5.197E-7 0 24363 gtex_brain_putamen_basal
rs1736081 8 11702840 CTSB ENSG00000164733.16 2.995E-7 0 24117 gtex_brain_putamen_basal
rs1692811 8 11703048 CTSB ENSG00000164733.16 5.34E-7 0 23909 gtex_brain_putamen_basal
rs1736082 8 11703420 CTSB ENSG00000164733.16 5.102E-7 0 23537 gtex_brain_putamen_basal
rs1736083 8 11703497 CTSB ENSG00000164733.16 5.544E-7 0 23460 gtex_brain_putamen_basal
rs1692812 8 11703523 CTSB ENSG00000164733.16 5.554E-7 0 23434 gtex_brain_putamen_basal
rs1736084 8 11703657 CTSB ENSG00000164733.16 5.102E-7 0 23300 gtex_brain_putamen_basal
rs1736085 8 11703659 CTSB ENSG00000164733.16 5.102E-7 0 23298 gtex_brain_putamen_basal
rs1736086 8 11704897 CTSB ENSG00000164733.16 1.766E-6 0 22060 gtex_brain_putamen_basal
rs1692819 8 11705448 CTSB ENSG00000164733.16 9.144E-8 0 21509 gtex_brain_putamen_basal
rs1736089 8 11705870 CTSB ENSG00000164733.16 6.551E-8 0 21087 gtex_brain_putamen_basal
rs2740594 8 11707174 CTSB ENSG00000164733.16 5.048E-8 0 19783 gtex_brain_putamen_basal
rs2645417 8 11708800 CTSB ENSG00000164733.16 9.882E-8 0 18157 gtex_brain_putamen_basal
rs2740595 8 11708830 CTSB ENSG00000164733.16 4.785E-8 0 18127 gtex_brain_putamen_basal
rs1293289 8 11709945 CTSB ENSG00000164733.16 2.317E-6 0 17012 gtex_brain_putamen_basal
rs1293292 8 11710369 CTSB ENSG00000164733.16 2.241E-6 0 16588 gtex_brain_putamen_basal
rs1122182 8 11710629 CTSB ENSG00000164733.16 2.195E-6 0 16328 gtex_brain_putamen_basal
rs34504234 8 11711113 CTSB ENSG00000164733.16 6.443E-7 0 15844 gtex_brain_putamen_basal
rs1293296 8 11711157 CTSB ENSG00000164733.16 6.474E-7 0 15800 gtex_brain_putamen_basal
rs1293298 8 11712443 CTSB ENSG00000164733.16 5.409E-7 0 14514 gtex_brain_putamen_basal
rs1736103 8 11712639 CTSB ENSG00000164733.16 3.941E-8 0 14318 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 16364318
GO:0004197 cysteine-type endopeptidase activity IEA -
GO:0004197 cysteine-type endopeptidase activity TAS 1645961
GO:0008233 peptidase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006508 proteolysis IEA -
GO:0006508 proteolysis TAS 3463996
GO:0042981 regulation of apoptosis TAS 16130169
GO:0050790 regulation of catalytic activity IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular TAS 1645961
GO:0005739 mitochondrion IEA -
GO:0005764 lysosome IEA -
GO:0042470 melanosome IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
A2M CPAMD5 | DKFZp779B086 | FWP007 | S863-7 alpha-2-macroglobulin - HPRD 2476070
ANXA2 ANX2 | ANX2L4 | CAL1H | LIP2 | LPC2 | LPC2D | P36| PAP-IV annexin A2 - HPRD,BioGRID 10777578
APOE AD2 | LPG | MGC1571 | apoprotein apolipoprotein E - HPRD 12057992
BAT3 BAG-6 | BAG6 | D6S52E | G3 HLA-B associated transcript 3 Two-hybrid BioGRID 16169070
CST3 ARMD11 | MGC117328 cystatin C Reconstituted Complex BioGRID 14503883
CST3 ARMD11 | MGC117328 cystatin C - HPRD 1996959|7890620
CST7 CMAP cystatin F (leukocystatin) - HPRD 9632704|9733783
CSTA STF1 | STFA cystatin A (stefin A) Reconstituted Complex BioGRID 9585570|14503883
CSTA STF1 | STFA cystatin A (stefin A) - HPRD 9585570|10353845
|14503883
CSTB CST6 | EPM1 | PME | STFB cystatin B (stefin B) - HPRD,BioGRID 11514663
MARCKS 80K-L | FLJ14368 | FLJ90045 | MACS | MRACKS | PKCSL | PRKCSL myristoylated alanine-rich protein kinase C substrate - HPRD 9295331
S100A10 42C | ANX2L | ANX2LG | CAL1L | CLP11 | Ca[1] | GP11 | MGC111133 | P11 | p10 S100 calcium binding protein A10 - HPRD,BioGRID 10777578
SERPINB13 HSHUR7SEQ | HUR7 | MGC126870 | PI13 | headpin serpin peptidase inhibitor, clade B (ovalbumin), member 13 - HPRD 10512713


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG LYSOSOME 121 83 All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION 89 65 All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 14 10 All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION 91 61 All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279 178 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 118 84 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP 112 71 All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN 186 114 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430 232 All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158 103 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205 127 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 142 90 All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE UP 52 36 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 136 94 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293 179 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP 126 72 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP 120 73 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215 137 All SZGR 2.0 genes in this pathway
CHIN BREAST CANCER COPY NUMBER DN 16 10 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP 126 78 All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN 25 13 All SZGR 2.0 genes in this pathway
AIYAR COBRA1 TARGETS UP 39 25 All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS UP 49 35 All SZGR 2.0 genes in this pathway
TSUNODA CISPLATIN RESISTANCE DN 51 38 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
HOWLIN PUBERTAL MAMMARY GLAND 69 40 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
LIU BREAST CANCER 30 19 All SZGR 2.0 genes in this pathway
WEI MIR34A TARGETS 148 97 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
MORI PLASMA CELL UP 51 29 All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP 71 51 All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION 101 66 All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK UP 42 24 All SZGR 2.0 genes in this pathway
NADLER OBESITY UP 61 34 All SZGR 2.0 genes in this pathway
LIAN NEUTROPHIL GRANULE CONSTITUENTS 25 13 All SZGR 2.0 genes in this pathway
APPEL IMATINIB RESPONSE 33 22 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293 160 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN 74 55 All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 6M 74 47 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP 56 35 All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART DN 42 32 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 3M 59 36 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245 144 All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 71 42 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253 147 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE 77 50 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 132 93 All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245 148 All SZGR 2.0 genes in this pathway
ZHANG GATA6 TARGETS DN 64 46 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN UP 181 112 All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER MARKERS 19 16 All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS DN 36 21 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354 216 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP 134 84 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS EMT UP 36 24 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198 128 All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS 80 56 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 122 84 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315 201 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 DN 40 26 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN 207 139 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242 159 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397 206 All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 145 83 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 1 DN 63 39 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
DELPUECH FOXO3 TARGETS UP 68 49 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238 125 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-186 59 66 1A,m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU