Gene Page:ADRA2B

Summary?
GeneID 151
Symbol ADRA2B
Synonyms ADRA2L1|ADRA2RL1|ADRARL1|ALPHA2BAR|FAME2|alpha-2BAR
Description adrenoceptor alpha 2B
Reference MIM:104260|HGNC:HGNC:282|Ensembl:ENSG00000274286|HPRD:00086|Vega:OTTHUMG00000188276
Gene type protein-coding
Map location 2q11.1
Pascal p-value 0.042
Fetal beta -0.347
eGene Cerebellar Hemisphere
Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
ADT:Sun_2012 Systematic Investigation of Antipsychotic Drugs and Their Targets A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0004
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10958910 chr9 10134759 ADRA2B 151 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
UNC93B3 0.68 0.68
CXCL16 0.66 0.71
PARP12 0.64 0.68
TNFRSF1A 0.64 0.68
SLC15A3 0.63 0.69
HLA-E 0.62 0.68
LGALS9 0.61 0.69
BAMBI 0.60 0.64
FAH 0.60 0.65
IRF1 0.60 0.65
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RTF1 -0.51 -0.54
SRPK1 -0.49 -0.51
ANKRD12 -0.49 -0.55
TMEM57 -0.48 -0.49
ZNF714 -0.48 -0.51
MPP3 -0.48 -0.50
KIDINS220 -0.48 -0.47
STMN1 -0.48 -0.53
BZW2 -0.48 -0.53
ZNF91 -0.48 -0.51

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IEA -
GO:0004938 alpha2-adrenergic receptor activity TAS 2164221
GO:0004935 adrenoceptor activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007186 G-protein coupled receptor protein signaling pathway TAS 2164221
GO:0007267 cell-cell signaling TAS 2164221
GO:0007165 signal transduction IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005886 plasma membrane TAS 2164221
GO:0005887 integral to plasma membrane TAS 2164221

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS 38 33 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195 114 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Z SIGNALLING EVENTS 44 29 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
REACTOME PLATELET AGGREGATION PLUG FORMATION 36 23 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153 100 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
CHESLER BRAIN D6MIT150 QTL TRANS 9 7 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 142 103 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 69 48 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN 113 76 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210 148 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-139 914 920 1A hsa-miR-139brain UCUACAGUGCACGUGUCU
miR-23 854 860 m8 hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-30-5p 893 899 m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-323 854 860 1A hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-329 939 945 m8 hsa-miR-329brain AACACACCUGGUUAACCUCUUU
miR-330 816 822 1A hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-377 941 948 1A,m8 hsa-miR-377 AUCACACAAAGGCAACUUUUGU