Gene Page:CYLC2
Summary?
| GeneID | 1539 |
| Symbol | CYLC2 |
| Synonyms | - |
| Description | cylicin, basic protein of sperm head cytoskeleton 2 |
| Reference | MIM:604035|HGNC:HGNC:2583|Ensembl:ENSG00000155833|HPRD:04945|Vega:OTTHUMG00000020396 |
| Gene type | protein-coding |
| Map location | 9q31.1 |
| Pascal p-value | 0.346 |
| Fetal beta | 0.171 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Expression | Meta-analysis of gene expression | Pvalue: 1.379 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| USP12 | 0.37 | 0.33 |
| ARHGEF3 | 0.36 | 0.31 |
| TASP1 | 0.35 | 0.31 |
| TRPC1 | 0.35 | 0.31 |
| CNTN3 | 0.34 | 0.35 |
| AC012652.1 | 0.34 | 0.33 |
| RIMBP2 | 0.34 | 0.33 |
| AL031003.1 | 0.34 | 0.36 |
| DLG2 | 0.34 | 0.34 |
| AL133410.3 | 0.34 | 0.34 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TP53I13 | -0.24 | -0.23 |
| IMPA2 | -0.23 | -0.22 |
| ACAA2 | -0.23 | -0.19 |
| NKAIN4 | -0.23 | -0.22 |
| AQP5 | -0.23 | -0.22 |
| RHOC | -0.22 | -0.26 |
| AC217773.2 | -0.22 | -0.22 |
| H2AFJ | -0.22 | -0.29 |
| IL17RC | -0.22 | -0.23 |
| TRIP6 | -0.22 | -0.21 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005200 | structural constituent of cytoskeleton | TAS | 7737358 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0007283 | spermatogenesis | IEA | - | |
| GO:0007275 | multicellular organismal development | IEA | - | |
| GO:0030154 | cell differentiation | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005856 | cytoskeleton | IEA | - | |
| GO:0005737 | cytoplasm | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| XU HGF TARGETS REPRESSED BY AKT1 DN | 95 | 58 | All SZGR 2.0 genes in this pathway |
| SU TESTIS | 76 | 53 | All SZGR 2.0 genes in this pathway |
| IWANAGA CARCINOGENESIS BY KRAS PTEN UP | 181 | 112 | All SZGR 2.0 genes in this pathway |