Gene Page:ADRB2

概括?
GeneID 154
Symbol ADRB2
Synonyms ADRB2R|ADRBR|B2AR|BAR|BETA2AR
Description Adrenoceptor Beta 2
Reference MIM:109690|HGNC:HGNC:286|HPRD:00187|
Gene type protein-coding
Map location 5q31-q32
Pascal p-value 0.415
Sherlock p-value 0.076
Fetal beta -0.561
eGene Myers' cis & trans
Support GPCR SIGNALLING

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统ematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIE 基因组扫描荟萃分析（欧洲官方样品） Psr: 0.01718
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.00459
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 达到与neuro-related keywords: 2
Network 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 Contribution to shortest path in PPI network: 4.6166

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10994209 chr10 61877705 ADRB2 154 0.15 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MAP2 0.89 0.92
DCLK1 0.88 0.91
KIF3B 0.87 0.89
MAPRE2 0.86 0.89
ABI2 0.86 0.90
GNAQ 0.86 0.90
DLG3 0.86 0.89
CAMSAP1L1 0.86 0.90
PAFAH1B1 0.86 0.89
EDEM3 0.85 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FXYD1 -0.64 -0.69
HSD17B14 -0.63 -0.68
HIGD1B -0.63 -0.71
METRN -0.63 -0.72
TLCD1 -0.63 -0.68
ENHO -0.63 -0.75
ACSF2 -0.62 -0.69
RAB34 -0.62 -0.69
MT-CO2 -0.62 -0.68
AF347015.31 -0.62 -0.67

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0051380 norepinephrine binding IDA Neurotransmitter (GO term level: 4) 15123695
GO:0004872 receptor activity IEA -
GO:0004941 beta2-adrenergic receptor activity IDA 15123695
GO:0005515 protein binding 新闻学会 9560162
GO:0042803 protein homodimerization activity IDA 15123695
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0000187 activation of MAPK activity TAS 9924018
GO:0002024 diet induced thermogenesis IEA -
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IEA -
GO:0002028 regulation of sodium ion transport IEA -
GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA 15123695
GO:0007190 activation of adenylate cyclase activity IDA 15123695
GO:0007189 G-protein signaling, adenylate cyclase activating pathway IEA -
GO:0007186 G-protein coupled receptor protein signaling pathway TAS 9924018
GO:0007243 protein kinase cascade TAS 10734107
GO:0008333 endosome to lysosome transport TAS 9507004
GO:0009409 response to cold IEA -
GO:0006898 receptor-mediated endocytosis IDA 15123695
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity TAS 10734107
GO:0040015 negative regulation of multicellular organism growth IEA -
GO:0030501 positive regulation of bone mineralization IEA -
GO:0050873 brown fat cell differentiation IEA -
GO:0031649 heat generation IEA -
GO:0043410 positive regulation of MAPKKK cascade IDA 15123695
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA -
GO:0045986 negative regulation of smooth muscle contraction IEA -
GO:0045453 骨吸收 IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0043235 receptor complex IDA Neurotransmitter (GO term level: 4) 15123695
GO:0005624 membrane fraction IEA -
GO:0005634 nucleus IEA -
GO:0005764 lysosome TAS 9507004
GO:0005768 endosome TAS 10734107
GO:0005886 plasma membrane IDA 9235896
GO:0005887 integral to plasma membrane TAS 9228019
GO:0016324 apical plasma membrane IEA -

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental 资源 PubMed ID
ADRB2 ADRB2R | ADRBR | B2AR | BAR | BETA2AR adrenergic, beta-2-, receptor, surface FRET BioGRID 11278447
ADRBK1 BARK1 | BETA-ARK1 | FLJ16718 | GRK2 adrenergic, beta, receptor kinase 1 Affinity Capture-Western BioGRID 11309381
AKAP12 AKAP250 | DKFZp686M0430 | DKFZp686O0331 | FLJ20945 | FLJ97621 A kinase (PRKA) anchor protein 12 - HPRD,BioGRID 9880537|11309381 | 11309381
AKAP5 AKAP75 | AKAP79 | H21 A kinase (PRKA) anchor protein 5 - HPRD 10753752
ARR3 ARRX arrestin 3, retinal (X-arrestin) - HPRD 11877451
EIF2B1 EIF-2B | EIF-2Balpha | EIF2B | EIF2BA | MGC117409 | MGC125868 | MGC125869 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa eIF2B-alpha interacts with the cytoplasmic, carboxy-terminus of the beta-2 adrenergic receptor. BIND 9235896
EIF2B1 EIF-2B | EIF-2Balpha | EIF2B | EIF2BA | MGC117409 | MGC125868 | MGC125869 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa - HPRD,BioGRID 9235896
GNA11 GNA-11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) - HPRD 7797501
GNA14 - guanine nucleotide binding protein (G protein), alpha 14 - HPRD 7797501
GNA15 GNA16 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) - HPRD 7608160|7797501
GRB2 ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 growth factor receptor-bound protein 2 - HPRD,BioGRID 9830057
GRK6 FLJ32135 | GPRK6 G蛋白偶联受体激酶6 - HPRD,BioGRID 9819198
KCNJ3 GIRK1 | KGA | KIR3.1 potassium inwardly-rectifying channel, subfamily J, member 3 Affinity Capture-Western BioGRID 12297500
KCNJ5 CIR | GIRK4 | KATP1 | KIR3.4 potassium inwardly-rectifying channel, subfamily J, member 5 Affinity Capture-Western BioGRID 12297500
KCNJ6 BIR1 | GIRK2 | KATP2 | KCNJ7 | KIR3.2 | MGC126596 | hiGIRK2 potassium inwardly-rectifying channel, subfamily J, member 6 - HPRD 12297500
KCNJ9 GIRK3 | KIR3.3 potassium inwardly-rectifying channel, subfamily J, member 9 - HPRD 12297500
OPRD1 OPRD opioid receptor, delta 1 - HPRD,BioGRID 11278447
PPP3CA CALN | CALNA | CALNA1 | CCN1 | CNA1 | PPP2B protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform Co-fractionation BioGRID 9880537
SLC9A3R1 EBP50 | NHERF | NHERF1 | NPHLOP2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 - HPRD,BioGRID 9560162|9671706
SLC9A3R1 EBP50 | NHERF | NHERF1 | NPHLOP2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 PDZ domain of NHERF binds to the C-terminus of B2AR. BIND 9560162|9671706
|12621035
SLC9A3R2 E3KARP | MGC104639 | NHE3RF2 | NHERF-2 | NHERF2 | OCTS2 | SIP-1 | SIP1 | TKA-1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 PDZ1 domain of NHERF-2 interacts with the C-terminal tail of beta2-AR. BIND 9671706
SLC9A3R2 E3KARP | MGC104639 | NHE3RF2 | NHERF-2 | NHERF2 | OCTS2 | SIP-1 | SIP1 | TKA-1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 - HPRD,BioGRID 9671706
SRC ASV | SRC1 | c-SRC | p60-Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Affinity Capture-Western BioGRID 11013230


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 该途径中的所有SZGR 2.0基因
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 该途径中的所有SZGR 2.0基因
KEGG ENDOCYTOSIS 183 132 该途径中的所有SZGR 2.0基因
BIOCARTA GCR PATHWAY 22 17 该途径中的所有SZGR 2.0基因
BIOCARTA CFTR PATHWAY 12 11 该途径中的所有SZGR 2.0基因
BIOCARTA PLCE PATHWAY 12 10 该途径中的所有SZGR 2.0基因
PID ARF6 TRAFFICKING PATHWAY 49 34 该途径中的所有SZGR 2.0基因
PID ARF6 PATHWAY 35 27 该途径中的所有SZGR 2.0基因
REACTOME SIGNALING BY GPCR 920 449 该途径中的所有SZGR 2.0基因
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 该途径中的所有SZGR 2.0基因
REACTOME AMINE LIGAND BINDING RECEPTORS 38 33 该途径中的所有SZGR 2.0基因
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 该途径中的所有SZGR 2.0基因
REACTOME G ALPHA S SIGNALLING EVENTS 121 82 该途径中的所有SZGR 2.0基因
REACTOME GPCR LIGAND BINDING 408 246 该途径中的所有SZGR 2.0基因
ONKEN UVEAL MELANOMA DN 526 357 该途径中的所有SZGR 2.0基因
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320 184 该途径中的所有SZGR 2.0基因
LIU TARGETS OF VMYB VS CMYB DN 43 30 该途径中的所有SZGR 2.0基因
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 该途径中的所有SZGR 2.0基因
BASAKI YBX1 TARGETS UP 290 177 该途径中的所有SZGR 2.0基因
vecchi胃癌早期DN 367 220 该途径中的所有SZGR 2.0基因
MULLIGHAN MLL SIGNATURE 1 UP 380 236 该途径中的所有SZGR 2.0基因
MULLIGHAN MLL SIGNATURE 2 UP 418 263 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE KERATINOCYTE DN 485 334 该途径中的所有SZGR 2.0基因
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153 100 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 该途径中的所有SZGR 2.0基因
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
RASHI RESPONSE TO IONIZING RADIATION 1 45 27 该途径中的所有SZGR 2.0基因
Simbulan UV响应正常DN 33 27 该途径中的所有SZGR 2.0基因
NUYTTEN EZH2 TARGETS UP 1037 673 该途径中的所有SZGR 2.0基因
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 该途径中的所有SZGR 2.0基因
KOYAMA SEMA3B TARGETS UP 292 168 该途径中的所有SZGR 2.0基因
AMIT SERUM RESPONSE 240 MCF10A 57 36 该途径中的所有SZGR 2.0基因
MORI MATURE B LYMPHOCYTE UP 90 62 该途径中的所有SZGR 2.0基因
ONDER CDH1 TARGETS 2 DN 464 276 该途径中的所有SZGR 2.0基因
ONDER CDH1 SIGNALING VIA CTNNB1 83 58 该途径中的所有SZGR 2.0基因
Hoegerkorp CD44靶向直接 27 21 该途径中的所有SZGR 2.0基因
DAZARD RESPONSE TO UV NHEK DN 318 220 该途径中的所有SZGR 2.0基因
BILD HRAS ONCOGENIC SIGNATURE 261 166 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 该途径中的所有SZGR 2.0基因
HELLER SILENCED BY METHYLATION DN 105 67 该途径中的所有SZGR 2.0基因
SAGIV CD24 TARGETS DN 46 26 该途径中的所有SZGR 2.0基因
BOQUEST STEM CELL DN 216 143 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
SWEET LUNG CANCER KRAS DN 435 289 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 该途径中的所有SZGR 2.0基因
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176 110 该途径中的所有SZGR 2.0基因
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN 179 97 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME2 491 319 该途径中的所有SZGR 2.0基因
WONG ADULT TISSUE STEM MODULE 721 492 该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 0 76 54 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE LATE 1137 655 该途径中的所有SZGR 2.0基因
WINZEN DEGRADED VIA KHSRP 100 70 该途径中的所有SZGR 2.0基因
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 300 307 1A,m8 hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain agagguaguagguugcauagu
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
mir-15/16/195/424/497 334 340 m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-200bc/429 315 321 1A HSA-MIR-200B UAAUACUGCCUGGUAAUGAUGAC
HSA-MIR-200C UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-30-5p 522 528 1A hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-381 96 102 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU