Gene Page:CYP1B1

Summary?
GeneID 1545
Symbol CYP1B1
Synonyms CP1B|CYPIB1|GLC3A|P4501B1
Description cytochrome P450 family 1 subfamily B member 1
Reference MIM:601771|HGNC:HGNC:2597|Ensembl:ENSG00000138061|HPRD:03464|Vega:OTTHUMG00000100970
Gene type protein-coding
Map location 2p22.2
Pascal p-value 0.54
Sherlock p-value 0.01
Fetal beta -0.552
eGene Myers' cis & trans
Support G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs848206 chr1 16252995 CYP1B1 1545 0.02 trans
rs848215 chr1 16267146 CYP1B1 1545 0.09 trans
rs1320385 chr1 54064468 CYP1B1 1545 0.04 trans
rs12036675 chr1 54066317 CYP1B1 1545 0.04 trans
rs12062528 chr1 54070830 CYP1B1 1545 0.06 trans
rs4522651 chr2 34048 CYP1B1 1545 1.931E-4 trans
rs2839839 chr2 51691483 CYP1B1 1545 0.03 trans
rs6739534 chr2 51702264 CYP1B1 1545 0.09 trans
rs1911135 chr2 228688488 CYP1B1 1545 0.01 trans
rs2922180 chr3 125280472 CYP1B1 1545 5.091E-6 trans
rs2971271 chr3 125450402 CYP1B1 1545 0.05 trans
rs2976809 chr3 125451738 CYP1B1 1545 0.05 trans
rs1395157 chr5 40055537 CYP1B1 1545 0.05 trans
rs16888672 chr5 58126580 CYP1B1 1545 0.16 trans
rs16894149 chr5 61013724 CYP1B1 1545 0.06 trans
rs17558509 chr5 125107290 CYP1B1 1545 0.01 trans
rs6595634 chr5 125113615 CYP1B1 1545 0.01 trans
rs185323 chr5 154212519 CYP1B1 1545 9.615E-4 trans
rs702743 chr5 154271390 CYP1B1 1545 0.04 trans
rs816736 chr5 154271947 CYP1B1 1545 1.061E-7 trans
rs816748 chr5 154274691 CYP1B1 1545 9.615E-4 trans
rs863650 chr5 154281215 CYP1B1 1545 0.04 trans
rs348737 chr5 154297807 CYP1B1 1545 0.19 trans
rs1390602 chr5 154385024 CYP1B1 1545 9.615E-4 trans
rs17570361 chr5 154397675 CYP1B1 1545 9.615E-4 trans
rs9389245 chr6 135265648 CYP1B1 1545 0.04 trans
rs2529439 chr7 30643747 CYP1B1 1545 0.05 trans
rs2240404 chr7 30707301 CYP1B1 1545 0.17 trans
rs4723002 chr7 30725700 CYP1B1 1545 0.01 trans
rs4723003 chr7 30725740 CYP1B1 1545 0.01 trans
rs7841407 chr8 9243427 CYP1B1 1545 0 trans
rs2739708 chr8 17992280 CYP1B1 1545 0.16 trans
rs714131 chr8 17992832 CYP1B1 1545 0.17 trans
rs16876827 chr8 30148763 CYP1B1 1545 0.09 trans
rs10955813 chr8 118415080 CYP1B1 1545 0.13 trans
rs10969120 chr9 29400711 CYP1B1 1545 0.13 trans
rs4743989 chr9 97859191 CYP1B1 1545 0.02 trans
rs356660 chr9 98006134 CYP1B1 1545 0.16 trans
rs10886877 chr10 85425690 CYP1B1 1545 0.1 trans
rs7071168 chr10 95829674 CYP1B1 1545 0.05 trans
rs4612791 chr11 40768423 CYP1B1 1545 0.07 trans
rs11115813 chr12 83808239 CYP1B1 1545 0.01 trans
rs17054673 chr13 58610114 CYP1B1 1545 0.19 trans
snp_a-2256421 0 CYP1B1 1545 0.13 trans
rs17070066 chr13 58661554 CYP1B1 1545 0.17 trans
rs6587203 chr17 19671457 CYP1B1 1545 0.09 trans
rs205113 chr17 19673879 CYP1B1 1545 0.09 trans
rs205111 chr17 19675103 CYP1B1 1545 0.09 trans
rs205110 chr17 19675587 CYP1B1 1545 0.09 trans
rs205093 chr17 19685712 CYP1B1 1545 0.09 trans
rs157406 chr17 19710650 CYP1B1 1545 0.09 trans
rs157402 chr17 19720588 CYP1B1 1545 0.09 trans
rs157396 chr17 19726832 CYP1B1 1545 0.09 trans
rs157397 chr17 19729494 CYP1B1 1545 0.09 trans
rs8074258 0 CYP1B1 1545 0.09 trans
rs172186 chr17 19780658 CYP1B1 1545 0.01 trans
rs281334 chr17 19782079 CYP1B1 1545 0.09 trans
rs4586510 chr17 19783973 CYP1B1 1545 0.09 trans
rs9959804 chr18 20264142 CYP1B1 1545 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG STEROID HORMONE BIOSYNTHESIS 55 30 All SZGR 2.0 genes in this pathway
KEGG TRYPTOPHAN METABOLISM 40 33 All SZGR 2.0 genes in this pathway
KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 70 44 All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 139 91 All SZGR 2.0 genes in this pathway
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 51 34 All SZGR 2.0 genes in this pathway
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 70 50 All SZGR 2.0 genes in this pathway
REACTOME ENDOGENOUS STEROLS 15 10 All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205 140 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244 153 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP 175 120 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367 220 All SZGR 2.0 genes in this pathway
斯米尔诺夫循环内皮细胞癌症 158 103 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN GRANULOCYTE DN 7 6 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187 115 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE DN 17 13 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE DN 54 38 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN MONOCYTE DN 8 7 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP 171 112 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP 57 33 All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL DIVIDING UP 13 7 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 DN 51 35 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP 120 73 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP 238 135 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
LI CISPLATIN RESISTANCE UP 28 20 All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 4NM DN 7 6 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER 111 69 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP 108 66 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP 127 79 All SZGR 2.0 genes in this pathway
WOTTON RUNX TARGETS UP 21 14 All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP 77 60 All SZGR 2.0 genes in this pathway
FRIDMAN IMMORTALIZATION DN 34 24 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP 116 79 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER F 54 32 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP 69 55 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 HELA 69 47 All SZGR 2.0 genes in this pathway
霁转移REPRESSED BY STK11 27 17 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256 159 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 140 85 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 3 UP 17 11 All SZGR 2.0 genes in this pathway
HOUSTIS ROS 36 29 All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP 71 51 All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO ESTRADIOL UP 37 28 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
NAKAJIMA MAST CELL 46 34 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP 203 135 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
CHUANG OXIDATIVE STRESS RESPONSE UP 28 18 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228 146 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 12 36 18 All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION UP 83 49 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN 91 64 All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 128 93 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428 266 All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN 51 32 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE DN 51 28 All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261 166 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220 147 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS DN 105 63 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
OSADA ASCL1 TARGETS DN 24 20 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
BUCKANOVICH T LYMPHOCYTE HOMING ON TUMOR UP 24 11 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 UP 111 69 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR UP 101 65 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
VISALA AGING LYMPHOCYTE UP 10 7 All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS UP 127 78 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295 155 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315 215 All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS UP 163 111 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 4 110 66 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
KRIEG KDM3A TARGETS NOT HYPOXIA 208 107 All SZGR 2.0 genes in this pathway