Gene Page:ADRBK2

Summary?
GeneID 157
Symbol ADRBK2
Synonyms BARK2|GRK3
Description adrenergic, beta, receptor kinase 2
Reference MIM:109636|HGNC:HGNC:290|Ensembl:ENSG00000100077|HPRD:00183|Vega:OTTHUMG00000150280
Gene type protein-coding
Map location 22q12.1
Pascal p-value 0.756
Sherlock p-value 0.972
Fetal beta -0.801
eGene Anterior cingulate cortex BA24
Cerebellar Hemisphere
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.031
Literature High-throughput literature-search Co-occurance和Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2712089 chr2 24080273 ADRBK2 157 0.01 trans
rs1437904 chr2 133830789 ADRBK2 157 0.15 trans
rs13418573 chr2 205418512 ADRBK2 157 0.1 trans
rs17032578 chr3 3555893 ADRBK2 157 0.15 trans
rs1155107 chr3 26843376 ADRBK2 157 0.01 trans
rs17029291 chr3 32402138 ADRBK2 157 2.647E-6 trans
rs830202 chr3 165654796 ADRBK2 157 0.19 trans
rs6843749 chr4 84847249 ADRBK2 157 0.11 trans
rs16901958 chr5 44776555 ADRBK2 157 0.08 trans
rs750544 chr5 51749054 ADRBK2 157 0 trans
rs17146240 chr5 119522933 ADRBK2 157 0.08 trans
rs17146261 chr5 119534252 ADRBK2 157 0.08 trans
rs2807510 chr6 73090536 ADRBK2 157 0.17 trans
rs4617108 chr7 49423831 ADRBK2 157 0.02 trans
rs7894597 chr10 9384581 ADRBK2 157 0.17 trans
rs12253630 chr10 74768923 ADRBK2 157 0.16 trans
rs7078127 chr10 74847633 ADRBK2 157 0.1 trans
rs12569493 chr10 74886042 ADRBK2 157 0 trans
rs16930362 chr10 74890320 ADRBK2 157 0 trans
rs2271904 chr10 74894374 ADRBK2 157 0.1 trans
rs7092445 chr10 74921991 ADRBK2 157 0.03 trans
rs12256576 chr10 74934313 ADRBK2 157 0.19 trans
rs1867565 chr10 74977780 ADRBK2 157 0.14 trans
rs11000557 chr10 74987393 ADRBK2 157 0.15 trans
rs16915029 chr10 75001994 ADRBK2 157 0.07 trans
rs16930466 chr10 75007587 ADRBK2 157 0.13 trans
rs11000607 chr10 75089777 ADRBK2 157 0.07 trans
rs6480700 chr10 75101689 ADRBK2 157 0.16 trans
rs16930573 chr10 75167645 ADRBK2 157 0.2 trans
rs12571454 chr10 75208954 ADRBK2 157 0.03 trans
rs7949511 chr11 67938847 ADRBK2 157 0.11 trans
rs7935070 chr11 67982990 ADRBK2 157 0.17 trans
rs1324669 chr13 107872446 ADRBK2 157 4.751E-5 trans
snp_a-2212061 0 ADRBK2 157 0.18 trans
rs3742829 chr14 73489267 ADRBK2 157 0.09 trans
rs8055506 chr16 13661723 ADRBK2 157 0.08 trans
rs16962446 chr16 13694936 ADRBK2 157 0.13 trans
rs3924428 chr16 25934820 ADRBK2 157 0.13 trans
rs16958358 chr17 55502410 ADRBK2 157 0.17 trans
rs6098023 chr20 53113740 ADRBK2 157 0 trans
rs6015314 chr20 57167224 ADRBK2 157 0.05 trans
rs12157904 chr22 37982011 ADRBK2 157 0.13 trans
rs17145698 chrX 40218345 ADRBK2 157 0.13 trans
rs17328938 chrX 99519447 ADRBK2 157 0.17 trans
rs1335267 chrX 99570223 ADRBK2 157 0.17 trans
rs5760786 22 25395342 ADRBK2 ENSG00000100077.10 1.08E-6 0.03 -565474 gtex_brain_ba24
rs5760793 22 25400511 ADRBK2 ENSG00000100077.10 1.146E-6 0.03 -560305 gtex_brain_ba24
rs3859864 22 25402318 ADRBK2 ENSG00000100077.10 1.388E-6 0.03 -558498 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RNF123 0.91 0.90
NISCH 0.90 0.90
SLC45A1 0.90 0.89
AP1B1 0.90 0.89
ATP6AP1 0.90 0.90
ATP13A2 0.89 0.90
ABCB9 0.89 0.87
AP2A2 0.89 0.89
SLC27A4 0.89 0.90
FAM134A 0.88 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.67 -0.63
AP002478.3 -0.62 -0.61
MT-CO2 -0.62 -0.57
AF347015.31 -0.62 -0.56
AF347015.8 -0.61 -0.56
NOSTRIN -0.61 -0.56
GNG11 -0.60 -0.59
AF347015.33 -0.59 -0.53
MT-CYB -0.59 -0.53
AF347015.2 -0.58 -0.50

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0004871 signal transducer activity IEA -
GO:0004703 G-protein coupled receptor kinase activity IEA -
GO:0005524 ATP binding IEA -
GO:0016740 transferase activity IEA -
GO:0047696 beta-adrenergic receptor kinase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006468 protein amino acid phosphorylation IEA -
GO:0007165 signal transduction TAS 8427589
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 18029348
GO:0005886 plasma membrane IDA 18029348

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
KEGG OLFACTORY TRANSDUCTION 389 85 All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 57 43 All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 43 32 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206 111 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP 85 54 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS UP 92 64 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195 138 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 11Q23 DELETION 23 18 All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN 86 66 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 74 51 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
BUCKANOVICH T LYMPHOCYTE HOMING ON TUMOR UP 24 11 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245 150 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN 204 114 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176 110 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 130 87 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491 319 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway