Gene Page:CYP4B1

Summary?
GeneID 1580
Symbol CYP4B1
Synonyms CYPIVB1|P-450HP
Description cytochrome P450 family 4 subfamily B member 1
Reference MIM:124075|HGNC:HGNC:2644|Ensembl:ENSG00000142973|HPRD:00491|Vega:OTTHUMG00000007984
Gene type protein-coding
Map location 1p33
Pascal p-value 0.175
Fetal beta -0.118
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17131472 chr1 91962966 CYP4B1 1580 0.06 trans
rs3762382 chr1 198128858 CYP4B1 1580 0.12 trans
rs6546473 chr2 69260356 CYP4B1 1580 0.07 trans
rs1566993 chr2 117105059 CYP4B1 1580 0.13 trans
rs10050805 chr5 30805352 CYP4B1 1580 0.17 trans
rs9381511 chr6 12931447 CYP4B1 1580 0.07 trans
rs6455226 chr6 67930295 CYP4B1 1580 0 trans
rs7081666 chr10 47673800 CYP4B1 1580 0.1 trans
rs10733768 chr10 52667246 CYP4B1 1580 0.02 trans
rs1159612 chr10 85329057 CYP4B1 1580 0.01 trans
rs10879027 chr12 70237156 CYP4B1 1580 0.02 trans
rs16958302 chr16 57647432 CYP4B1 1580 0.06 trans
rs6506551 chr18 8167049 CYP4B1 1580 0.18 trans
rs4805564 chr19 30911055 CYP4B1 1580 0.04 trans
rs6095741 chr20 48666589 CYP4B1 1580 2.007E-8 trans
rs5915713 chrX 4077883 CYP4B1 1580 0.02 trans
rs5991662 chrX 43335796 CYP4B1 1580 0 trans
rs1545676 chrX 93530472 CYP4B1 1580 1.266E-4 trans
rs242163 chrX 132311662 CYP4B1 1580 0.06 trans
rs17340148 chrX 138648246 CYP4B1 1580 0 trans
rs10521801 chrX 138732866 CYP4B1 1580 0.06 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CSRP2 0.83 0.55
AP000926.2 0.82 0.71
SLA 0.80 0.78
C8orf79 0.79 0.73
PTPRO 0.79 0.75
POU3F2 0.77 0.68
DOPEY2 0.77 0.70
KRT31 0.77 0.72
VSTM2L 0.76 0.75
SEMA3C 0.76 0.74
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HEPN1 -0.54 -0.68
HLA-F -0.53 -0.62
RENBP -0.53 -0.67
AIFM3 -0.53 -0.66
CLU -0.53 -0.62
TSC22D4 -0.52 -0.67
AP003117.1 -0.52 -0.58
FAH -0.52 -0.66
HSD17B14 -0.52 -0.67
BDH2 -0.52 -0.69

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME BIOLOGICAL OXIDATIONS 139 91 All SZGR 2.0 genes in this pathway
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 51 34 All SZGR 2.0 genes in this pathway
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 70 50 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA DN 349 157 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244 147 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450 256 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 DN 149 93 All SZGR 2.0 genes in this pathway
萨斯博士排毒通路和致癌DN 13 11 All SZGR 2.0 genes in this pathway
LIN SILENCED BY TUMOR MICROENVIRONMENT 108 73 All SZGR 2.0 genes in this pathway
SUZUKI RESPONSE TO TSA AND DECITABINE 1A 23 16 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE UP 38 23 All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP 103 69 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 53 34 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154 101 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 120 81 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BRAIN DN 85 58 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A UP 84 52 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 134 83 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403 240 All SZGR 2.0 genes in this pathway