Gene Page:CYP7A1
Summary?
| GeneID | 1581 |
| Symbol | CYP7A1 |
| Synonyms | CP7A|CYP7|CYPVII |
| Description | cytochrome P450 family 7 subfamily A member 1 |
| Reference | MIM:118455|HGNC:HGNC:2651|Ensembl:ENSG00000167910|HPRD:00324|Vega:OTTHUMG00000164301 |
| Gene type | protein-coding |
| Map location | 8q11-q12 |
| Pascal p-value | 0.029 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RTKN | 0.92 | 0.94 |
| GSN | 0.92 | 0.90 |
| APOD | 0.91 | 0.93 |
| PLA2G16 | 0.91 | 0.94 |
| CHADL | 0.91 | 0.91 |
| TMC6 | 0.90 | 0.88 |
| PLLP | 0.90 | 0.91 |
| SEMA3B | 0.90 | 0.85 |
| MVP | 0.90 | 0.91 |
| RHOG | 0.89 | 0.81 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NKIRAS2 | -0.67 | -0.74 |
| CRMP1 | -0.65 | -0.75 |
| ZBTB8A | -0.65 | -0.74 |
| ZNF821 | -0.64 | -0.73 |
| MPP3 | -0.64 | -0.73 |
| KIAA1949 | -0.64 | -0.68 |
| STMN2 | -0.64 | -0.75 |
| STMN1 | -0.64 | -0.74 |
| PPP3CC | -0.64 | -0.75 |
| HN1 | -0.64 | -0.74 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PRIMARY BILE ACID BIOSYNTHESIS | 16 | 9 | All SZGR 2.0 genes in this pathway |
| KEGG STEROID HORMONE BIOSYNTHESIS | 55 | 30 | All SZGR 2.0 genes in this pathway |
| KEGG PPAR SIGNALING PATHWAY | 69 | 47 | All SZGR 2.0 genes in this pathway |
| REACTOME BILE ACID AND BILE SALT METABOLISM | 27 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | 15 | 6 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS | 19 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME PPARA ACTIVATES GENE EXPRESSION | 104 | 72 | All SZGR 2.0 genes in this pathway |
| REACTOME BIOLOGICAL OXIDATIONS | 139 | 91 | All SZGR 2.0 genes in this pathway |
| REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | 51 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | 70 | 50 | All SZGR 2.0 genes in this pathway |
| REACTOME ENDOGENOUS STEROLS | 15 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
| REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 168 | 115 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | All SZGR 2.0 genes in this pathway |
| KHETCHOUMIAN TRIM24 TARGETS DN | 8 | 7 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON | 132 | 82 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER CIPROFIBRATE DN | 66 | 43 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER MYC UP | 54 | 30 | All SZGR 2.0 genes in this pathway |
| UEDA PERIFERAL CLOCK | 169 | 111 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER DENA DN | 74 | 45 | All SZGR 2.0 genes in this pathway |
| WENG POR TARGETS GLOBAL UP | 20 | 14 | All SZGR 2.0 genes in this pathway |
| WENG POR DOSAGE | 21 | 9 | All SZGR 2.0 genes in this pathway |
| ZAMORA NOS2 TARGETS DN | 96 | 71 | All SZGR 2.0 genes in this pathway |
| WENG POR TARGETS LIVER UP | 41 | 29 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| YAMASHITA LIVER CANCER STEM CELL DN | 76 | 51 | All SZGR 2.0 genes in this pathway |
| SERVITJA LIVER HNF1A TARGETS UP | 135 | 96 | All SZGR 2.0 genes in this pathway |