Gene Page:ADSS

Summary?
GeneID 159
Symbol ADSS
Synonyms ADEH|ADSS 2
Description adenylosuccinate synthase
Reference MIM:103060|HGNC:HGNC:292|Ensembl:ENSG00000035687|HPRD:00050|Vega:OTTHUMG00000040102
Gene type protein-coding
Map location 1q44
Fetal beta -0.08
DMG 2 (# studies)
eGene 元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search 系统搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg01012879 1 244613363 ADSS 4.14E-5 -0.582 0.021 DMG:Wockner_2014
cg19375676 1 244615173 ADSS 4.73E-9 -0.009 2.73E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ZDHHC5 0.92 0.93
DGCR2 0.92 0.93
ALKBH5 0.90 0.90
AP2A1 0.90 0.89
NOL6 0.88 0.90
ARHGEF11 0.88 0.89
RPTOR 0.88 0.91
TRAPPC9 0.88 0.88
PVR 0.88 0.89
C2orf18 0.88 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.73 -0.73
AF347015.31 -0.67 -0.65
MT-CO2 -0.65 -0.65
C1orf54 -0.65 -0.69
GNG11 -0.64 -0.63
AF347015.8 -0.63 -0.63
SYCP3 -0.62 -0.69
AL050337.1 -0.62 -0.68
AP002478.3 -0.61 -0.61
HIGD1B -0.61 -0.61

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000287 magnesium ion binding IEA -
GO:0004019 adenylosuccinate synthase activity IDA 2004783
GO:0004019 adenylosuccinate synthase activity IEA -
GO:0004019 adenylosuccinate synthase activity NAS 1592113
GO:0005525 GTP binding IEA -
GO:0005525 GTP binding NAS 1592113|15786719
GO:0016874 ligase activity IEA -
GO:0042301 phosphate binding NAS 1592113|15786719
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0002376 immune system process NAS 15786719
GO:0006167 AMP biosynthetic process IDA 2004783
GO:0006167 AMP biosynthetic process NAS 1592113|15786719
去:0006164 purine nucleotide biosynthetic process IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005575 cellular_component ND -
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PURINE METABOLISM 159 96 All SZGR 2.0 genes in this pathway
KEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISM 32 26 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF NUCLEOTIDES 72 45 All SZGR 2.0 genes in this pathway
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 11 8 All SZGR 2.0 genes in this pathway
REACTOME PURINE METABOLISM 33 24 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 159 93 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176 104 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
TCGA GLIOBLASTOMA COPY NUMBER UP 75 36 All SZGR 2.0 genes in this pathway
LIN APC TARGETS 77 55 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION UP 83 49 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198 132 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T4 94 69 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-19 392 399 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-214 533 539 1A hsa-miR-214brain ACAGCAGGCACAGACAGGCAG