Gene Page:CYP26A1

Summary?
GeneID 1592
Symbol CYP26A1
Synonyms CP26|CYP26|P450RAI|P450RAI1
Description cytochrome P450 family 26 subfamily A member 1
Reference MIM:602239|HGNC:HGNC:2603|Ensembl:ENSG00000095596|HPRD:03759|Vega:OTTHUMG00000018765
Gene type protein-coding
Map location 10q23-q24
Pascal p-value 0.251
Fetal beta 2.123

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RNF13 0.89 0.84
OMG 0.88 0.86
CPEB1 0.88 0.92
LIPA 0.87 0.86
LAMP2 0.87 0.87
ENDOD1 0.84 0.77
PPAP2A 0.84 0.86
GCLC 0.84 0.80
TPD52 0.83 0.83
NIPAL3 0.83 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SH3BP2 -0.55 -0.64
KIAA1949 -0.55 -0.53
TUBB2B -0.54 -0.62
SH2B2 -0.54 -0.63
PLEKHO1 -0.53 -0.54
TRAF4 -0.52 -0.62
ZNF300 -0.51 -0.41
ZNF311 -0.50 -0.45
NR2C2AP -0.50 -0.50
PPP1R14B -0.50 -0.63

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0001972 retinoic acid binding IDA 10823918
GO:0005506 iron ion binding IEA -
GO:0004497 monooxygenase activity IEA -
GO:0019825 oxygen binding TAS 9228017
GO:0020037 heme binding IEA -
GO:0008401 retinoic acid 4-hydroxylase activity IDA 9228017|10823918
GO:0009055 electron carrier activity IEA -
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007417 central nervous system development IEA Brain (GO term level: 6) -
GO:0009952 anterior/posterior pattern formation IEA -
GO:0014032 neural crest cell development IEA -
GO:0042573 retinoic acid metabolic process IEA -
GO:0048384 retinoic acid receptor signaling pathway IEA -
GO:0048387 negative regulation of retinoic acid receptor signaling pathway TAS 14532297
GO:0034653 retinoic acid catabolic process IDA 10823918
GO:0055114 oxidation reduction IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005792 microsome IEA -
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005783 endoplasmic reticulum IEA -
GO:0016020 membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG RETINOL METABOLISM 64 37 All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 139 91 All SZGR 2.0 genes in this pathway
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 51 34 All SZGR 2.0 genes in this pathway
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 70 50 All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183 119 All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL UP 146 99 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP 149 84 All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR 62 33 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS DN 8 7 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER E 89 44 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
BENPORATH ES 2 40 21 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP 197 110 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN 66 43 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 DN 65 39 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC UP 54 30 All SZGR 2.0 genes in this pathway
BHATTACHARYA EMBRYONIC STEM CELL 89 60 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP 175 116 All SZGR 2.0 genes in this pathway
VARELA ZMPSTE24 TARGETS UP 40 30 All SZGR 2.0 genes in this pathway
WENG POR TARGETS LIVER UP 41 29 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 131 79 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269 159 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 8 49 36 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317 190 All SZGR 2.0 genes in this pathway
SCHMIDT POR TARGETS IN LIMB BUD UP 26 21 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157 105 All SZGR 2.0 genes in this pathway