Gene Page:AP2A2
概括?
| 基因 | 161 |
| 象征 | AP2A2 |
| Synonyms | adtab | clapa2 | hip-9 | hip9 | hypj |
| Description | adaptor related protein complex 2 alpha 2 subunit |
| Reference | MIM:607242|HGNC:HGNC:562|Ensembl:ENSG00000183020|HPRD:06256|Vega:OTTHUMG00000165627 |
| Gene type | protein-coding |
| Map location | 11p15.5 |
| Pascal p-value | 0.351 |
| Sherlock P值 | 0.886 |
| Fetal beta | -0.558 |
| DMG | 1（＃研究） |
| eGene | 元 |
| Support | 内吞作用 G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_clathrin g2cdb.human_synaptosom COMPOSITESET Darnell FMRP targets Ascano FMRP targets |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV：GWASDB | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 4 |
| DNM：XU_2012 | Whole Exome Sequencing analysis | De novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study |
第一节遗传学和表观遗传学注释
DNM table
DNM table| Gene | Chromosome | Position | Ref | alt | Transcript | AA change | Mutation type | 筛 | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| AP2A2 | chr11 | 972194 | G | A | NM_001242837 NM_012305 |
p.138v> m p.138v> m |
错过 错过 |
精神分裂症 | DNM：XU_2012 |
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg27402845 | 11 | 1000533 | AP2A2 | 7.95E-5 | 0.342 | 0.025 | DMG:Wockner_2014 |
| cg20229025 | 11 | 971902 | AP2A2 | 1.118E-4 | 0.757 | 0.029 | DMG:Wockner_2014 |
| cg22143635 | 11 | 980567 | AP2A2 | 1.306E-4 | 0.405 | 0.03 | DMG:Wockner_2014 |
| cg21551979 | 11 | 972057 | AP2A2 | 3.664E-4 | 0.673 | 0.042 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| polr3a | 0.96 | 0.97 |
| MARCH6 | 0.96 | 0.97 |
| WDR36 | 0.95 | 0.97 |
| CCNT1 | 0.95 | 0.96 |
| DYRK1A | 0.95 | 0.97 |
| DCTN4 | 0.95 | 0.97 |
| C4ORF41 | 0.95 | 0.96 |
| WDR26 | 0.95 | 0.96 |
| COG3 | 0.95 | 0.96 |
| PPP1R15B | 0.95 | 0.96 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FXYD1 | -0.80 | -0.86 |
| AF347015.31 | -0.79 | -0.86 |
| MT-CO2 | -0.78 | -0.86 |
| HIGD1B | -0.77 | -0.86 |
| IFI27 | -0.76 | -0.84 |
| AF347015.33 | -0.76 | -0.82 |
| AF347015.8 | -0.74 | -0.84 |
| mt-cyb | -0.74 | -0.82 |
| HSD17B14 | -0.74 | -0.78 |
| AF347015.27 | -0.74 | -0.82 |
第四节。蛋白质蛋白相互作用注释
| 互动者 | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| AMPH | AMPH1 | amphiphysin | Reconstituted Complex | BioGRID | 9280305 |
| AP1S1 | AP19 | CLAPS1 | FLJ92436 | SIGMA1A | WUGSC:H_DJ0747G18.2 | adaptor-related protein complex 1, sigma 1 subunit | - | HPRD | 11707398 |
| AP2B1 | ADTB2 | AP105B | AP2-BETA | CLAPB1 | DKFZp781K0743 | adaptor-related protein complex 2, beta 1 subunit | - | HPRD | 12086608 |
| ATM | AT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1 | ataxia telangiectasia mutated | Protein-peptide | BioGRID | 10608806 |
| ATR | FRP1 | MEC1 | SCKL | SCKL1 | 共济失调的毛细血管扩张和RAD3相关 | Protein-peptide | BioGRID | 10608806 |
| BIN1 | AMPH2 | AMPHL | DKFZp547F068 | MGC10367 | SH3P9 | 桥接整合器1 | - | HPRD | 10430869 |
| CLTC | CHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034 | clathrin, heavy chain (Hc) | Reconstituted Complex | BioGRID | 9280305 |
| DAB2 | DOC-2 | DOC2 | FLJ26626 | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | Affinity Capture-Western | BioGRID | 11247302 |
| DNAJC6 | DJC6 | KIAA0473 | MGC129914 | MGC129915 | MGC48436 | DnaJ (Hsp40) homolog, subfamily C, member 6 | - | HPRD | 11470803 |
| DNM1 | DNM | dynamin 1 | - | HPRD | 10430869 |
| EPN1 | - | epsin 1 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 9723620 |
| EPS15 | AF-1P |AF1P |mllt5 | epidermal growth factor receptor pathway substrate 15 | - | HPRD | 9049247 |
| EPS15 | AF-1P |AF1P |mllt5 | epidermal growth factor receptor pathway substrate 15 | Reconstituted Complex | BioGRID | 10809762 |
| HTT | 高清| IT15 | huntingtin | 两个杂交 | BioGRID | 9700202 |
| RALBP1 | RIP1 | RLIP1 | RLIP76 | rala结合蛋白1 | RLIP76 interacts with alpha-adaptin. | BIND | 10910768 |
| SHC1 | FLJ26504 | SHC | SHCA | SHC (Src homology 2 domain containing) transforming protein 1 | - | HPRD,BioGRID | 8617812 |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ENDOCYTOSIS | 183 | 132 | 该途径中的所有SZGR 2.0基因 |
| KEGG HUNTINGTONS DISEASE | 185 | 109 | 该途径中的所有SZGR 2.0基因 |
| REACTOMESIGNALLING BY NGF | 217 | 167 | 该途径中的所有SZGR 2.0基因 |
| REACTOMEDEVELOPMENTAL BIOLOGY | 396 | 292 | 该途径中的所有SZGR 2.0基因 |
| Reactome Nef通过募集到网格蛋白适配器来介导细胞表面受体的调节 | 21 | 12 | 该途径中的所有SZGR 2.0基因 |
| REACTOMESIGNALING BY EGFR IN CANCER | 109 | 80 | 该途径中的所有SZGR 2.0基因 |
| REACTOMENGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 137 | 105 | 该途径中的所有SZGR 2.0基因 |
| Reactome MHC II类抗原表现 | 91 | 61 | 该途径中的所有SZGR 2.0基因 |
| REACTOMERETROGRADE NEUROTROPHIN SIGNALLING | 13 | 7 | 该途径中的所有SZGR 2.0基因 |
| REACTOMEEGFR DOWNREGULATION | 25 | 14 | 该途径中的所有SZGR 2.0基因 |
| REACTOMETRANSMISSION ACROSS CHEMICAL SYNAPSES | 186 | 155 | 该途径中的所有SZGR 2.0基因 |
| REACTOMENEURONAL SYSTEM | 279 | 221 | 该途径中的所有SZGR 2.0基因 |
| REACTOMENEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL | 137 | 110 | 该途径中的所有SZGR 2.0基因 |
| REACTOMEAXON GUIDANCE | 251 | 188 | 该途径中的所有SZGR 2.0基因 |
| REACTOMETRAFFICKING OF AMPA RECEPTORS | 28 | 23 | 该途径中的所有SZGR 2.0基因 |
| REACTOMETRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | 16 | 11 | 该途径中的所有SZGR 2.0基因 |
| REACTOMEL1CAM INTERACTIONS | 86 | 62 | 该途径中的所有SZGR 2.0基因 |
| L1反应组信号转导 | 34 | 25 | 该途径中的所有SZGR 2.0基因 |
| L1的Reactome回收途径 | 27 | 15 | 该途径中的所有SZGR 2.0基因 |
| REACTOMEHIV INFECTION | 207 | 122 | 该途径中的所有SZGR 2.0基因 |
| Reactome宿主的艾滋病毒因素的相互作用 | 132 | 81 | 该途径中的所有SZGR 2.0基因 |
| REACTOMETHE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | 28 | 19 | 该途径中的所有SZGR 2.0基因 |
| REACTOMEIMMUNE SYSTEM | 933 | 616 | 该途径中的所有SZGR 2.0基因 |
| REACTOMEADAPTIVE IMMUNE SYSTEM | 539 | 350 | 该途径中的所有SZGR 2.0基因 |
| PARENT MTOR SIGNALING UP | 567 | 375 | 该途径中的所有SZGR 2.0基因 |
| Fulcher炎症反应凝集素与LPS DN | 463 | 290 | 该途径中的所有SZGR 2.0基因 |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | 该途径中的所有SZGR 2.0基因 |
| GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN | 206 | 136 | 该途径中的所有SZGR 2.0基因 |
| STARK HYPPOCAMPUS 22Q11 DELETION UP | 53 | 40 | 该途径中的所有SZGR 2.0基因 |
| WANG PROSTATE CANCER ANDROGEN INDEPENDENT | 66 | 37 | 该途径中的所有SZGR 2.0基因 |
| LEI MYB TARGETS | 318 | 215 | 该途径中的所有SZGR 2.0基因 |
| IVANOVA HEMATOPOIESIS MATURE CELL | 293 | 160 | 该途径中的所有SZGR 2.0基因 |
| Ramalho茎DN | 74 | 55 | 该途径中的所有SZGR 2.0基因 |
| 由Foxp3绑定的Marson未刺激 | 1229 | 713 | 该途径中的所有SZGR 2.0基因 |
| WANG TUMOR INVASIVENESS DN | 210 | 128 | 该途径中的所有SZGR 2.0基因 |
| MILI PSEUDOPODIA CHEMOTAXIS DN | 457 | 302 | 该途径中的所有SZGR 2.0基因 |
| 米利假足型haptotaxis dn | 668 | 419 | 该途径中的所有SZGR 2.0基因 |
| WANG METASTASIS OF BREAST CANCER ESR1 DN | 30 | 18 | 该途径中的所有SZGR 2.0基因 |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | 该途径中的所有SZGR 2.0基因 |
| Delacroix Rarg Bound MEF | 367 | 231 | 该途径中的所有SZGR 2.0基因 |