Gene Page:DAO

Summary?
GeneID 1610
Symbol DAO
Synonyms DAAO|DAMOX|OXDA
Description D-amino-acid oxidase
Reference MIM:124050|HGNC:HGNC:2671|Ensembl:ENSG00000110887|HPRD:15917|Vega:OTTHUMG00000169360
Gene type protein-coding
Map location 12q24
Pascal p-value 0.269
Fetal beta 0.061
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 3 Link to SZGene
Literature High-throughput literature-search Co-occurance与精神分裂a keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 46

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2502827 chr1 176044216 DAO 1610 0.08 trans
rs17572651 chr1 218943612 DAO 1610 8.48E-6 trans
snp_a-1919794 0 DAO 1610 0.04 trans
rs16829545 chr2 151977407 DAO 1610 4.606E-11 trans
rs3845734 chr2 171125572 DAO 1610 0.14 trans
rs7584986 chr2 184111432 DAO 1610 2.161E-13 trans
rs9810143 chr3 5060209 DAO 1610 0.08 trans
rs4488887 chr4 177695833 DAO 1610 0.13 trans
rs10491487 chr5 80323367 DAO 1610 2.491E-5 trans
rs1368303 chr5 147672388 DAO 1610 1.667E-6 trans
rs1929769 chr6 40765977 DAO 1610 0.02 trans
rs4897051 chr6 149118925 DAO 1610 0.04 trans
rs3118341 chr9 25185518 DAO 1610 0.11 trans
rs9406868 chr9 25223372 DAO 1610 0.07 trans
rs11139334 chr9 84209393 DAO 1610 0.13 trans
rs17263352 chr9 124811572 DAO 1610 0.15 trans
rs7074445 chr10 88088121 DAO 1610 0.04 trans
rs17410931 chr10 98912175 DAO 1610 0.13 trans
rs754765 chr10 132013664 DAO 1610 0.06 trans
rs11612748 chr12 59007670 DAO 1610 0.04 trans
rs17104720 chr14 77127308 DAO 1610 0.18 trans
rs6574467 chr14 79179744 DAO 1610 0.01 trans
rs10146003 chr14 79191170 DAO 1610 0.01 trans
rs16955618 chr15 29937543 DAO 1610 3.078E-24 trans
snp_a-1830894 0 DAO 1610 0.11 trans
rs17681878 chr18 34767223 DAO 1610 0.1 trans
rs17085767 chr18 69839397 DAO 1610 0.05 trans
rs6019060 chr20 46965832 DAO 1610 0.01 trans
rs749043 chr20 46995700 DAO 1610 0.02 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RHOC 0.79 0.81
MTCP1NB 0.72 0.73
PSME2 0.72 0.71
FGGY 0.71 0.74
CD63 0.71 0.73
S100A16 0.70 0.75
C1orf61 0.68 0.77
CD58 0.67 0.67
C1orf54 0.67 0.73
NKAIN4 0.66 0.71
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PRDM2 -0.68 -0.77
A2BP1 -0.67 -0.78
MAGI2 -0.64 -0.71
CNNM2 -0.63 -0.70
BRPF3 -0.63 -0.71
AC016910.1 -0.63 -0.73
ANK3 -0.63 -0.73
ZBTB38 -0.63 -0.71
UBP1 -0.62 -0.71
HERC1 -0.62 -0.72

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003884 D-amino-acid oxidase activity IEA -
GO:0003884 D-amino-acid oxidase activity TAS 1356107
GO:0005524 ATP binding IEA -
GO:0004812 aminoacyl-tRNA ligase activity IEA -
GO:0016491 oxidoreductase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006418 tRNA aminoacylation for protein translation IEA -
GO:0008152 metabolic process IEA -
GO:0006551 leucine metabolic process IEA -
GO:0055114 oxidation reduction IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IEA -
GO:0005777 peroxisome NAS 2901986

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCINE SERINE AND THREONINE METABOLISM 31 26 All SZGR 2.0 genes in this pathway
KEGG ARGININE AND PROLINE METABOLISM 54 39 All SZGR 2.0 genes in this pathway
KEGG PEROXISOME 78 47 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI UP 92 58 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN 179 97 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS POLYSOMY7 UP 79 50 All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE DN 80 54 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266 180 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN 210 141 All SZGR 2.0 genes in this pathway