Gene Page:MDGA2

Summary?
GeneID 161357
Symbol MDGA2
Synonyms MAMDC1|c14_5286
Description MAM domain containing glycosylphosphatidylinositol anchor 2
Reference MIM:611128|HGNC:HGNC:19835|Ensembl:ENSG00000139915|HPRD:14352|Vega:OTTHUMG00000029429
Gene type protein-coding
Map location 14q21.3
Pascal p-value 4.236E-4
Fetal beta -0.246
DMG 2 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search 系统的search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg13687915 14 47311141 MDGA2 3.696E-4 -0.628 0.043 DMG:Wockner_2014
cg18115064 14 48143618 MDGA2 4.58平台以及 -0.022 8.11E-7 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0021522 spinal cord motor neuron differentiation ISS neuron, Brain (GO term level: 9) 15019943
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IDA 18029348
GO:0005886 plasma membrane IEA -
GO:0031225 anchored to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
TAKADA GASTRIC CANCER COPY NUMBER DN 29 15 All SZGR 2.0 genes in this pathway
DAWSON METHYLATED IN LYMPHOMA TCL1 59 45 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-10 437 444 1A,m8 hsa-miR-10a UACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10b UACCCUGUAGAACCGAAUUUGU
miR-124/506 817 823 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-129-5p 1409 1415 1A hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-130/301 861 867 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-139 1752 1758 1A hsa-miR-139brain UCUACAGUGCACGUGUCU
miR-140 781 787 m8 hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-148/152 862 868 m8 hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-153 1643 1649 1A hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-200bc/429 1664 1670 1A hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-21 634 640 1A hsa-miR-21brain UAGCUUAUCAGACUGAUGUUGA
hsa-miR-590 GAGCUUAUUCAUAAAAGUGCAG
miR-218 1700 1707 1A,m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-299-5p 687 693 m8 hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-30-3p 1289 1295 1A hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p CUUUCAGUCGGAUGUUUACAGC
miR-33 1483 1489 m8 hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-363 1766 1772 1A hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
miR-380-5p 1120 1127 1A,m8 hsa-miR-380-5p UGGUUGACCAUAGAACAUGCGC
hsa-miR-563 AGGUUGACAUACGUUUCCC
miR-382 1783 1789 1A hsa-miR-382brain GAAGUUGUUCGUGGUGGAUUCG
miR-448 1643 1649 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-490 1104 1111 1A,m8 hsa-miR-490 CAACCUGGAGGACUCCAUGCUG
miR-494 368 374 1A hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
miR-7 1100 1106 1A hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG
miR-9 87 94 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA