Gene Page:DCTN1

Summary?
GeneID 1639
Symbol DCTN1
Synonyms DAP-150|DP-150|P135
Description dynactin subunit 1
Reference MIM:601143|HGNC:HGNC:2711|Ensembl:ENSG00000204843|HPRD:07206|Vega:OTTHUMG00000129963
Gene type protein-coding
Map location 2p13
Pascal p-value 0.543
Sherlock p-value 0.31
Fetal beta -1.376
eGene Myers' cis & trans
Support 我NTRACELLULAR TRAFFICKING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description 我nfo
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.3203

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7598660 chr2 73740424 DCTN1 1639 0.13 cis
rs11688718 chr2 73760938 DCTN1 1639 0.17 cis
rs4852939 chr2 73856768 DCTN1 1639 0.08 cis
rs4852316 chr2 73919657 DCTN1 1639 0.05 cis
rs17350056 chr2 73922876 DCTN1 1639 0.15 cis
rs12052539 chr2 73937152 DCTN1 1639 0.11 cis
rs17350188 chr2 73964841 DCTN1 1639 0.09 cis
rs12624267 chr2 73986930 DCTN1 1639 0.01 cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003774 motor activity 我EA -
GO:0005515 protein binding 我PI 9722614|15107855
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007399 nervous system development NAS neurite (GO term level: 5) 17360970
GO:0007067 mitosis NAS 1828535
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0000922 spindle pole 我DA 14718566
GO:0005856 cytoskeleton 我EA -
GO:0005874 microtubule 我EA -
GO:0005737 cytoplasm TAS 1828535
GO:0030286 dynein complex 我EA -

Section IV. Protein-protein interaction annotation

我nteractors Aliases B Official full name B Experimental Source PubMed ID
ACTR1A ARP1 | CTRN1 | FLJ52695 | FLJ52800 | FLJ55002 ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) - HPRD 7878030
AKTIP FT1 | FTS AKT interacting protein Affinity Capture-MS BioGRID 17353931
APEX1 APE | APE-1 | APE1 | APEN | APEX | APX | HAP1 | REF-1 | REF1 APEX nuclease (multifunctional DNA repair enzyme) 1 - HPRD 9361024
BBS4 - Bardet-Biedl syndrome 4 Affinity Capture-Western
Two-hybrid		 BioGRID 15107855
BICD2 KIAA0699 | bA526D8.1 bicaudal D homolog 2 (Drosophila) - HPRD 11483508|12447383
BZW1 BZAP45 | KIAA0005 | Nbla10236 基本亮氨酸拉链和W2域1 Affinity Capture-MS BioGRID 17353931
CASP2 CASP-2 | ICH-1L | ICH-1L/1S | ICH1 | NEDD2 caspase 2, apoptosis-related cysteine peptidase - HPRD 11425872
CASP3 CPP32 | CPP32B | SCA-1 caspase 3, apoptosis-related cysteine peptidase - HPRD 11425872
CASP7 CMH-1 | ICE-LAP3 | MCH3 caspase 7, apoptosis-related cysteine peptidase - HPRD 11425872
CLIP1 CLIP | CLIP-170 | CLIP170 | CYLN1 | MGC131604 | RSN CAP-GLY domain containing linker protein 1 - HPRD 12789661
DCTN2 DCTN50 | DYNAMITIN | RBP50 dynactin 2 (p50) p50dynamitin (DCTN2) interacts with an unspecified isoform of p150glued (DCTN1). BIND 15580264
DST BP240 | BPA | BPAG1 | CATX-15 | D6S1101 | DKFZp564B2416 | DMH | DT | FLJ46791 | KIAA0465 | KIAA1470 | MACF2 dystonin - HPRD,BioGRID 14581450
DYNC1H1 DHC1 | DHC1a | DKFZp686P2245 | DNCH1 | DNCL | DNECL | DYHC | Dnchc1 | HL-3 | KIAA0325 | p22 动力蛋白、胞质1,重链1 Affinity Capture-Western BioGRID 14600259
DYNC1I2 DNCI2 | FLJ21089 | FLJ90842 | IC2 | MGC104199 | MGC111094 | MGC9324 dynein, cytoplasmic 1, intermediate chain 2 - HPRD 8522607
EPB41 4.1R | EL1 | HE erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) Affinity Capture-Western BioGRID 10189366
GRB2 ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 growth factor receptor-bound protein 2 - HPRD,BioGRID 8955163
GSTK1 GST13 glutathione S-transferase kappa 1 Affinity Capture-MS BioGRID 17353931
HAP1 HAP2 | HIP5 | HLP | hHLP1 huntingtin-associated protein 1 - HPRD,BioGRID 9361024|9454836
HTT HD | IT15 huntingtin - HPRD 9454836
KIF11 EG5 | HKSP | KNSL1 | TRIP5 kinesin family member 11 - HPRD,BioGRID 9235942
MAP2K3 MAPKK3 | MEK3 | MKK3 | PRKMK3 mitogen-activated protein kinase kinase 3 - HPRD 15375157
MAP2K6 MAPKK6 | MEK6 | MKK6 | PRKMK6 | SAPKK3 mitogen-activated protein kinase kinase 6 - HPRD 15375157
MAPRE1 EB1 | MGC117374 | MGC129946 microtubule-associated protein, RP/EB family, member 1 - HPRD 12388762
PAFAH1B1 LIS1 | LIS2 | MDCR | MDS | PAFAH platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa - HPRD,BioGRID 11889140|14584027
PLK1 PLK | STPK13 polo-like kinase 1 (Drosophila) Affinity Capture-Western BioGRID 12852857
RAB6A RAB6 | RAB6A' | RAB6B RAB6A, member RAS oncogene family Reconstituted Complex
Two-hybrid		 BioGRID 12401177
RFXANK ANKRA1 | BLS | F14150_1 | MGC138628 | RFX-B regulatory factor X-associated ankyrin-containing protein Affinity Capture-MS BioGRID 17353931
SAR1A SAR1 | SARA1 | Sara | masra2 SAR1 homolog A (S. cerevisiae) Sar1p (SARA1) interacts with an unspecified isoform of p150glued (DCTN1). This interaction is probably indirect and bridged by Sec23p-Sec24p. BIND 15580264
SEC23A CLSD | MGC26267 Sec23 homolog A (S. cerevisiae) Sec23A interacts with p150glued (DCTN1). BIND 15580264
SEC24D FLJ43974 | KIAA0755 SEC24 family, member D (S. cerevisiae) Sec24D interacts with p150glued (DCTN1). BIND 15580264
SPTBN1 ELF | SPTB2 | betaSpII spectrin, beta, non-erythrocytic 1 Affinity Capture-Western BioGRID 8991093
SPTBN2 GTRAP41 | SCA5 spectrin, beta, non-erythrocytic 2 - HPRD,BioGRID 11461920
TP53BP1 53BP1 | FLJ41424 | MGC138366 | p202 tumor protein p53 binding protein 1 Affinity Capture-Western BioGRID 15611139
VIM FLJ36605 vimentin - HPRD,BioGRID 14600259


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway 我nfo
KEGG VASOPRESSIN REGULATED WATER REABSORPTION 44 30 All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185 109 All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY 33 32 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION 91 61 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 66 43 All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 59 38 All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 133 91 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S 46 34 All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE 80 51 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 81 50 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185 115 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165 107 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180 110 All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN 181 107 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER UP 57 35 All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGG VS IGA UP 22 12 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
JAIN NFKB SIGNALING 75 44 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP 69 41 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP 45 33 All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX DN 54 43 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP 69 46 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
MIZUSHIMA AUTOPHAGOSOME FORMATION 19 15 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-125/351 240 246 m8 hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain UCCCUGAGACCCUUUAACCUGUG