Gene Page:NQO1

Summary?
GeneID 1728
Symbol NQO1
Synonyms DHQU|DIA4|DTD|NMOR1|NMORI|QR1
Description NAD(P)H dehydrogenase, quinone 1
Reference MIM:125860|HGNC:HGNC:2874|Ensembl:ENSG00000181019|HPRD:00518|Vega:OTTHUMG00000137575
Gene type protein-coding
Map location 16q22.1
Pascal p-value 0.23
Sherlock p-value 0.543
Fetal beta -2.019
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17130488 chr1 68586295 NQO1 1728 0.03 trans
rs1367455 chr1 68615056 NQO1 1728 0.05 trans
rs7549490 chr1 167866399 NQO1 1728 0.01 trans
rs11578006 chr1 167929036 NQO1 1728 0.05 trans
snp_a-1971086 0 NQO1 1728 0.05 trans
rs7601007 chr2 83598858 NQO1 1728 0.03 trans
rs4676558 chr3 40084233 NQO1 1728 0.07 trans
rs17088743 chr4 58668728 NQO1 1728 0.02 trans
rs4867559 chr5 28462275 NQO1 1728 0.04 trans
rs16890314 chr5 59158770 NQO1 1728 0.08 trans
rs2045355 chr5 59981563 NQO1 1728 0.01 trans
rs6868941 chr5 124544154 NQO1 1728 0.19 trans
rs7710483 chr5 124558302 NQO1 1728 0.14 trans
rs630765 chr6 16771614 NQO1 1728 0.02 trans
rs9470413 chr6 36796613 NQO1 1728 0.1 trans
rs17578494 chr7 46073515 NQO1 1728 0.01 trans
rs1024675 chr7 51683191 NQO1 1728 0.01 trans
rs10491624 chr9 28781846 NQO1 1728 0.2 trans
rs16914428 chr9 29194496 NQO1 1728 0 trans
rs16923661 chr11 90368072 NQO1 1728 0.01 trans
rs7931323 chr11 127691959 NQO1 1728 0.11 trans
rs12303163 chr12 44409857 NQO1 1728 0.02 trans
rs17094401 chr12 44696783 NQO1 1728 0.02 trans
rs16940268 chr17 41938054 NQO1 1728 0.14 trans
rs7244040 chr18 13972023 NQO1 1728 0.16 trans
rs3813118 chr18 71814535 NQO1 1728 0.08 trans
rs515453 chr18 72483272 NQO1 1728 0.01 trans
rs7249597 chr19 49777931 NQO1 1728 0.01 trans
rs2073206 chr20 948279 NQO1 1728 0.01 trans
rs8120542 chr20 24395092 NQO1 1728 0.03 trans
rs8114637 chr20 24395207 NQO1 1728 0.03 trans
rs4536719 chr20 24397114 NQO1 1728 4.697E-5 trans
rs9974024 chr20 24397274 NQO1 1728 0.03 trans
rs6515493 chr20 24401635 NQO1 1728 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
USP12 0.88 0.90
STXBP5 0.88 0.90
KIF5C 0.88 0.86
RP4-788L13.1 0.86 0.89
MAP2 0.86 0.87
FRMPD4 0.86 0.87
DGKE 0.86 0.88
SCN2A 0.86 0.87
HOMER1 0.85 0.88
C9orf4 0.85 0.84
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RAB34 -0.52 -0.60
NUDT8 -0.50 -0.54
EIF4EBP3 -0.50 -0.54
RHOC -0.50 -0.58
DCI -0.49 -0.59
ACSF2 -0.49 -0.54
DBI -0.49 -0.57
C1orf61 -0.49 -0.63
ENHO -0.48 -0.56
DCXR -0.48 -0.55

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003955 NAD(P)H dehydrogenase (quinone) activity TAS 10393963
GO:0004128 cytochrome-b5 reductase activity TAS 9579781
GO:0009055 electron carrier activity IEA -
GO:0016491 oxidoreductase activity IEA -
GO:0050662 coenzyme binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007271 synaptic transmission, cholinergic TAS neuron, Cholinergic, Synap, Neurotransmitter (GO term level: 7) 9579781
GO:0009636 response to toxin TAS 10393963
GO:0006809 nitric oxide biosynthetic process TAS 9579781
GO:0006805 xenobiotic metabolic process TAS 10393963
GO:0006979 response to oxidative stress IEA -
GO:0055114 oxidation reduction IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm TAS 2843525

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA P53HYPOXIA PATHWAY 23 21 All SZGR 2.0 genes in this pathway
PID TAP63 PATHWAY 54 40 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC 49 33 All SZGR 2.0 genes in this pathway
在KEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA DN 349 157 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 175 82 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP 165 106 All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS UP 81 40 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185 126 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157 104 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP 44 30 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN 214 133 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA UP 141 75 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP 137 84 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS UP 68 41 All SZGR 2.0 genes in this pathway
BERENJENO ROCK SIGNALING NOT VIA RHOA UP 29 21 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
VETTER TARGETS OF PRKCA AND ETS1 DN 16 10 All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178 108 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA UP 29 24 All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS DN 24 17 All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP 110 71 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT DN 26 19 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
LEI HOXC8 TARGETS DN 17 13 All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING DN 90 57 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP 64 40 All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN 85 56 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165 100 All SZGR 2.0 genes in this pathway
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN 73 47 All SZGR 2.0 genes in this pathway
NADLER HYPERGLYCEMIA AT OBESITY 58 35 All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS UP 29 23 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP 83 66 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
在GUSAHA TP53 TARGETS 38 23 All SZGR 2.0 genes in this pathway
CHUANG OXIDATIVE STRESS RESPONSE UP 28 18 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR DN 101 70 All SZGR 2.0 genes in this pathway
KANG FLUOROURACIL RESISTANCE UP 22 15 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
KANG DOXORUBICIN RESISTANCE UP 54 33 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 3 101 64 All SZGR 2.0 genes in this pathway
MMS MOUSE LYMPH HIGH 4HRS UP 36 20 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 7 51 34 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 3MO DN 23 14 All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 6MO DN 21 12 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
SINGH NFE2L2 TARGETS 15 12 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
WONG MITOCHONDRIA GENE MODULE 217 122 All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE DN 88 42 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 147 83 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP 126 92 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER BRCA1 DN 44 28 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293 203 All SZGR 2.0 genes in this pathway
人士梅尔曼TUT1 DN的目标 47 29 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 134 83 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN 103 67 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242 146 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS UP 84 51 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 135 96 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway