Gene Page:DLD

Summary?
GeneID 1738
Symbol DLD
Synonyms DLDD|DLDH|E3|GCSL|LAD|PHE3
Description dihydrolipoamide dehydrogenase
Reference MIM:238331|HGNC:HGNC:2898|Ensembl:ENSG00000091140|HPRD:02006|Vega:OTTHUMG00000154813
Gene type protein-coding
Map location 7q31-q32
Pascal p-value 0.961
Sherlock p-value 0.074
Fetal beta -0.61
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Cortex
Frontal Cortex BA9
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_mitochondria
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
CV:PheWAS Phenome-wide association studies (PheWAS) 157 SNPs associated with schizophrenia 0
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
PMID:cooccur High-throughput literature-search 系统搜索PubMed通用电气nes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias,schizotypal Click to show details

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg05663655 7 107532014 DLD 3.56E-8 -0.011 1.04E-5 DMG:Jaffe_2016
cg18679886 7 107531975 DLD 5.23E-8 -0.009 1.37E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SIX3 0.96 0.31
C10orf41 0.93 0.37
PBX3 0.90 0.54
ZNF503 0.89 0.52
NTN1 0.88 0.39
RXRG 0.88 0.32
AC010997.1 0.88 0.52
POU3F4 0.88 0.45
AP000911.1 0.87 0.34
SP9 0.86 0.82
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CHPT1 -0.27 -0.22
CDADC1 -0.24 0.16
AF347015.31 -0.22 -0.44
C5orf53 -0.22 -0.29
COPZ2 -0.22 -0.43
MT-CO2 -0.22 -0.45
PTH1R -0.22 -0.23
MYL3 -0.21 -0.41
C16orf89 -0.21 -0.36
COX4I2 -0.21 -0.40

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCOLYSIS GLUCONEOGENESIS 62 41 All SZGR 2.0 genes in this pathway
KEGG CITRATE CYCLE TCA CYCLE 32 23 All SZGR 2.0 genes in this pathway
KEGG GLYCINE SERINE AND THREONINE METABOLISM 31 26 All SZGR 2.0 genes in this pathway
KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION 44 26 All SZGR 2.0 genes in this pathway
KEGG PYRUVATE METABOLISM 40 26 All SZGR 2.0 genes in this pathway
ST JNK MAPK PATHWAY 40 30 All SZGR 2.0 genes in this pathway
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 48 32 All SZGR 2.0 genes in this pathway
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 141 85 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 13 9 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
REACTOME CITRIC ACID CYCLE TCA CYCLE 26 16 All SZGR 2.0 genes in this pathway
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM 17 9 All SZGR 2.0 genes in this pathway
REACTOME PYRUVATE METABOLISM 19 14 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
RAHMAN TP53 TARGETS PHOSPHORYLATED 21 18 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261 183 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189 112 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
WONG MITOCHONDRIA GENE MODULE 217 122 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447 277 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298 174 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway