Gene Page:AFP

Summary?
GeneID 174
Symbol AFP
Synonyms AFPD|FETA|HPAFP
Description alpha fetoprotein
Reference MIM:104150|HGNC:HGNC:317|Ensembl:ENSG00000081051|HPRD:00074|Vega:OTTHUMG00000130011
Gene type protein-coding
Map location 4q13.3
Pascal p-value 0.199
Fetal beta -0.349
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16869851 chr4 20690056 AFP 174 0.12 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GDPD3 0.83 0.70
GNB3 0.82 0.70
LENG8 0.81 0.69
CCDC84 0.81 0.76
CYP2D6 0.81 0.63
MAMDC4 0.81 0.73
CDK3 0.81 0.68
PABPC1L 0.80 0.77
PILRB 0.80 0.77
NPEPL1 0.80 0.73
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CYCS -0.37 -0.41
DNAJB9 -0.36 -0.48
ITM2A -0.36 -0.38
ITM2B -0.36 -0.35
HIGD1A -0.36 -0.41
PIGK -0.35 -0.42
EFHA2 -0.34 -0.43
SGPP1 -0.34 -0.43
GHITM -0.34 -0.40
TPMT -0.34 -0.37

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID P73PATHWAY 79 59 All SZGR 2.0 genes in this pathway
PID HNF3B PATHWAY 45 37 All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 82 60 All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 137 94 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS D DN 9 6 All SZGR 2.0 genes in this pathway
DUTTA APOPTOSIS VIA NFKB 33 25 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM3 70 37 All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS UP 47 38 All SZGR 2.0 genes in this pathway
FUJIWARA PARK2 IN LIVER CANCER UP 8 7 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 2 114 76 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 DN 38 22 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS 128 77 All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 UP 65 44 All SZGR 2.0 genes in this pathway
JAZAERI BREAST CANCER BRCA1 VS BRCA2 UP 49 28 All SZGR 2.0 genes in this pathway
TUOMISTO TUMOR SUPPRESSION BY COL13A1 DN 17 11 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P4 100 62 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P7 90 52 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 156 92 All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER WITH H3K27ME3 196 93 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
MATZUK CENTRAL FOR FEMALE FERTILITY 29 25 All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN 108 64 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 108 68 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252 155 All SZGR 2.0 genes in this pathway
PIONTEK PKD1 TARGETS DN 18 12 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G12 UP 39 17 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP 178 108 All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP 109 68 All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER WITH EPCAM UP 53 25 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP 101 66 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 115 74 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA POOR SURVIVAL 16 9 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
CHANGOLKAR H2AFY TARGETS DN 40 26 All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 3 UP 89 50 All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 4 UP 19 12 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 135 96 All SZGR 2.0 genes in this pathway