Gene Page:DLX4

Summary?
GeneID 1748
Symbol DLX4
Synonyms BP1|DLX7|DLX8|DLX9|OFC15
Description distal-less homeobox 4
Reference MIM:601911|HGNC:HGNC:2917|Ensembl:ENSG00000108813|HPRD:03553|Vega:OTTHUMG00000161839
Gene type protein-coding
Map location 17q21.33
Pascal p-value 0.826
Fetal beta -0.33
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg00864183 17 48045973 DLX4 2.211E-4 -0.471 0.036 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
B4GALNT4 0.84 0.80
VARS2 0.84 0.83
ADAMTS10 0.84 0.83
MAMDC4 0.84 0.83
AC004410.1 0.84 0.84
SLC26A1 0.83 0.82
ANKS3 0.83 0.80
NBEAL2 0.82 0.86
CC2D1A 0.82 0.80
C19orf15 0.82 0.74
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KBTBD3 -0.57 -0.68
FAM162A -0.54 -0.58
ACOT13 -0.54 -0.57
C5orf53 -0.52 -0.50
ITM2B -0.51 -0.51
PLA2G4A -0.51 -0.52
B2M -0.50 -0.52
HIGD1A -0.50 -0.54
NDUFB5 -0.50 -0.60
CREM -0.49 -0.52

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
WILCOX RESPONSE TO PROGESTERONE UP 152 90 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244 153 All SZGR 2.0 genes in this pathway
TOMIDA METASTASIS DN 18 11 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC UP 62 38 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
SUZUKI RESPONSE TO TSA AND DECITABINE 1B 23 14 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION UP 83 49 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY UV 62 43 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226 164 All SZGR 2.0 genes in this pathway
LE SKI TARGETS DN 8 6 All SZGR 2.0 genes in this pathway
SHEDDEN肺癌A5生存良好 70 32 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269 159 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491 319 All SZGR 2.0 genes in this pathway