Gene Page:AGA

Summary?
GeneID 175
Symbol AGA
Synonyms AGU|ASRG|GA
Description aspartylglucosaminidase
Reference MIM:613228|HGNC:HGNC:318|Ensembl:ENSG00000038002|HPRD:01949|Vega:OTTHUMG00000160723
Gene type protein-coding
Map location 4q34.3
Pascal p-value 0.343
Sherlock p-value 0.434
Fetal beta -1.042
DMG 2 (# studies)
eGene Anterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2
PMID:cooccur High-throughput literature-search 系统ematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg21521452 4 178600548 AGA -0.038 0.25 DMG:Nishioka_2013
cg21521452 4 178588987-178589036 AGA 0.037 -2.491 DMG:vanEijk_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2271101 chr4 178359718 AGA 175 0.02 cis
rs1105059 4 178356461 AGA ENSG00000038002.4 1.137E-6 0.02 7196 gtex_brain_ba24
rs13149149 4 178360550 AGA ENSG00000038002.4 3.781E-7 0.02 3107 gtex_brain_ba24
rs4690522 4 178361051 AGA ENSG00000038002.4 4.123E-7 0.02 2606 gtex_brain_ba24
rs13133517 4 178361987 AGA ENSG00000038002.4 4.123E-7 0.02 1670 gtex_brain_ba24
rs13106192 4 178362122 AGA ENSG00000038002.4 3.753E-7 0.02 1535 gtex_brain_ba24
rs11131799 4 178363378 AGA ENSG00000038002.4 1.381E-6 0.02 279 gtex_brain_ba24
rs1105059 4 178356461 AGA ENSG00000038002.4 3.931E-10 0 7196 gtex_brain_putamen_basal
rs2271101 4 178359719 AGA ENSG00000038002.4 8.903E-9 0 3938 gtex_brain_putamen_basal
rs13149149 4 178360550 AGA ENSG00000038002.4 3.029E-11 0 3107 gtex_brain_putamen_basal
rs4690522 4 178361051 AGA ENSG00000038002.4 1.456E-10 0 2606 gtex_brain_putamen_basal
rs4690523 4 178361162 AGA ENSG00000038002.4 7.887E-9 0 2495 gtex_brain_putamen_basal
rs13133517 4 178361987 AGA ENSG00000038002.4 1.456E-10 0 1670 gtex_brain_putamen_basal
rs13106192 4 178362122 AGA ENSG00000038002.4 2.848E-11 0 1535 gtex_brain_putamen_basal
rs11131799 4 178363378 AGA ENSG00000038002.4 7.301E-10 0 279 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ZNF770 0.92 0.94
C3orf63 0.91 0.93
PIK3CA 0.91 0.93
IBTK 0.90 0.92
STAM2 0.90 0.92
LMAN1 0.89 0.93
RNGTT 0.89 0.91
CAMSAP1L1 0.89 0.91
C5orf51 0.89 0.91
ADAM10 0.89 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.68 -0.78
AF347015.31 -0.67 -0.76
FXYD1 -0.65 -0.72
AF347015.33 -0.65 -0.71
IFI27 -0.64 -0.72
HIGD1B -0.64 -0.74
AF347015.21 -0.64 -0.75
AF347015.8 -0.64 -0.74
MT-CYB -0.64 -0.72
AF347015.27 -0.63 -0.71

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG OTHER GLYCAN DEGRADATION 16 12 All SZGR 2.0 genes in this pathway
KEGG LYSOSOME 121 83 All SZGR 2.0 genes in this pathway
DEURIG T细胞PROLYMPHOCYTIC白血病 368 234 All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP 165 106 All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 127 78 All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS DN 35 22 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE UP 78 51 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP 126 92 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188 121 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA HP DN 47 23 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 365 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP 169 105 All SZGR 2.0 genes in this pathway