Gene Page:年代ARDH
年代ummary?
| GeneID | 1757 |
| 年代ymbol | 年代ARDH |
| 年代ynonyms | BPR-2|DMGDHL1|SAR|SARD|SDH |
| Description | sarcosine dehydrogenase |
| Reference | MIM:604455|HGNC:HGNC:10536|Ensembl:ENSG00000123453|HPRD:06831|Vega:OTTHUMG00000020879 |
| Gene type | protein-coding |
| Map location | 9q33-q34 |
| Pascal p-value | 0.304 |
| 年代herlock p-value | 0.179 |
| Fetal beta | 0.071 |
| DMG | 1 (# studies) |
| eGene | Cerebellum Nucleus accumbens basal ganglia 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| Expression | 元-analysis of gene expression | Pvalue: 1.979 |
年代ection I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | 年代tudy |
|---|---|---|---|---|---|---|---|
| cg14001893 | 9 | 136562840 | 年代ARDH | 3.207E-4 | -0.571 | 0.04 | DMG:Wockner_2014 |
年代ection II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | 年代pearman's Correlation |
| CR381670.2 | 0.59 | 0.18 |
| RGS4 | 0.54 | 0.59 |
| AL157769.1 | 0.53 | 0.06 |
| ACSM1 | 0.52 | 0.16 |
| MAL2 | 0.52 | 0.50 |
| USH2A | 0.50 | 0.33 |
| ALPK2 | 0.50 | 0.25 |
| OXR1 | 0.50 | 0.57 |
| RP11-413E6.1 | 0.49 | -0.07 |
| FER1L6 | 0.48 | 0.39 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | 年代pearman's Correlation |
| FADS2 | -0.31 | -0.33 |
| CENPB | -0.30 | -0.30 |
| BCL7C | -0.30 | -0.44 |
| PKN1 | -0.29 | -0.35 |
| METRNL | -0.29 | -0.44 |
| 年代EMA4B | -0.28 | -0.35 |
| 年代H2D2A | -0.28 | -0.40 |
| TRAF4 | -0.28 | -0.41 |
| 年代H2B2 | -0.28 | -0.40 |
| 年代H3BP2 | -0.28 | -0.40 |
年代ection III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004047 | aminomethyltransferase activity | IEA | - | |
| GO:0008480 | sarcosine dehydrogenase activity | IEA | - | |
| GO:0008480 | sarcosine dehydrogenase activity | TAS | 10444331 | |
| GO:0009055 | electron carrier activity | TAS | 10444331 | |
| GO:0016491 | oxidoreductase activity | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0008150 | biological_process | ND | - | |
| GO:0006546 | glycine catabolic process | IEA | - | |
| GO:0055114 | oxidation reduction | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | IEA | - | |
| GO:0005739 | mitochondrion | IEA | - | |
| GO:0005739 | mitochondrion | ISS | - | |
| GO:0005759 | mitochondrial matrix | IEA | - | |
| GO:0005759 | mitochondrial matrix | NAS | 10444331 |
年代ection V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLYCINE SERINE AND THREONINE METABOLISM | 31 | 26 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LIVE DN | 384 | 220 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | All SZGR 2.0 genes in this pathway |
| CASTELLANO NRAS TARGETS UP | 68 | 41 | All SZGR 2.0 genes in this pathway |
| DN CHEBOTAEV GR目标 | 120 | 73 | All SZGR 2.0 genes in this pathway |
| BERENJENO TRANSFORMED BY RHOA DN | 394 | 258 | All SZGR 2.0 genes in this pathway |
| 年代HETH LIVER CANCER VS TXNIP LOSS PAM4 | 261 | 153 | All SZGR 2.0 genes in this pathway |
| 年代HEPARD BMYB MORPHOLINO DN | 200 | 112 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
| MOOTHA HUMAN MITODB 6 2002 | 429 | 260 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G3 DN | 51 | 32 | All SZGR 2.0 genes in this pathway |
| WOO LIVER CANCER RECURRENCE DN | 80 | 54 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF LCP WITH H3K4ME3 | 128 | 68 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
| WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC LCP WITH H3K4ME3 | 58 | 34 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 16 | 79 | 47 | All SZGR 2.0 genes in this pathway |
| PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP | 134 | 85 | All SZGR 2.0 genes in this pathway |
| OHGUCHI LIVER HNF4A TARGETS DN | 149 | 85 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |