Gene Page:DRD1

概括?
基因 1812
象征 DRD1
Synonyms DADR|DRD1A
Description 多巴胺受体D1
参考 MIM:126449|HGNC:HGNC:3020|Ensembl：ENSG00000184845|HPRD:00538|Vega:OTTHUMG00000130557
Gene type protein-coding
Map location 5q35.1
Pascal p-value 0.107
Fetal beta -0.507
eGene 元
Support DOPAMINE
GPCR信号传导
Potential synaptic genes

数据源中的基因
Gene set name Method of gene set Description Info
ADT：SUN_2012 系统研究抗精神病药及其靶标 A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.0276
文学 High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症，精神分裂症 点击to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：9
Network 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 Contribution to shortest path in PPI network: 31

第一节遗传学和表观遗传学注释


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf42 0.78 0.80
AADAT 0.77 0.76
TCTN2 0.77 0.74
KCTD3 0.76 0.80
PROM1 0.75 0.75
ZC3H7A 0.74 0.81
REV3L 0.74 0.82
mgea5 0.74 0.78
TOR1B 0.74 0.76
BIVM 0.72 0.77
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
REEP6 -0.54 -0.49
AF347015.31 -0.54 -0.65
MT-CO2 -0.53 -0.65
AF347015.27 -0.53 -0.62
TSC22D4 -0.52 -0.56
IFI27 -0.51 -0.62
CA4 -0.51 -0.54
FXYD1 -0.51 -0.59
AF347015.33 -0.51 -0.60
AIFM3 -0.51 -0.51

Section III. Gene Ontology annotation

分子功能 GO term Evidence Neuro keywords PubMed ID
去：0001590 dopamine D1 receptor activity IEA dopamine (GO term level: 10) -
去：0004872 receptor activity IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0007416 synaptogenesis ISS 突触（GO期限：6） -
GO：0060158 多巴胺受体,越南河粉spholipase C activating pathway IGI dopamine (GO term level: 10) 17194762
GO：0051584 regulation of dopamine uptake IC 突触，神经递质，多巴胺（GO期限：11） 8301582
GO:0051968 突触传递，谷氨酸能的正调节 ISS neuron, glutamate, Synap, Neurotransmitter (GO term level: 10) -
GO:0007191 dopamine receptor, adenylate cyclase activating pathway IEA dopamine (GO term level: 12) -
GO:0019226 transmission of nerve impulse IEA neuron (GO term level: 5) -
GO：0021853 cerebral cortex GABAergic interneuron migration IEA neuron, GABA (GO term level: 14) -
GO:0042053 regulation of dopamine metabolic process IEA dopamine (GO term level: 9) -
GO:0001975 对苯丙胺的反应 IEA -
GO:0007187 G蛋白信号传导，与环状核苷酸第二信使耦合 IDA 1282671
GO:0007165 信号转导 IEA -
去：0008542 视觉学习 IEA -
GO:0010580 activation of adenylate cyclase activity involved in G-protein signaling IDA 2144334
GO:0007631 feeding behavior IEA -
GO:0007628 adult walking behavior IEA -
GO:0007626 locomotory behavior IEA -
GO:0007625 grooming behavior IEA -
GO:0007617 mating behavior IEA -
GO:0042493 对药物的反应 IEA -
去：0030432 蠕动 IEA -
GO：0051281 positive regulation of release of sequestered calcium ion into cytosol IDA 1282671|7838121
GO:0030819 营地生物合成过程的积极调节 IDA 1282671|7838121
去：0030335 细胞迁移的阳性调节 IEA -
GO：0043268 positive regulation of potassium ion transport ISS -
GO:0051482 elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) IDA 1282671
GO:0060134 抑制预抑制 IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005624 membrane fraction IEA -
GO:0005783 endoplasmic reticulum IEA -
GO:0005886 plasma membrane IDA 11500503
GO:0005887 质膜的积分 IC 2144334

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 该途径中的所有SZGR 2.0基因
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 该途径中的所有SZGR 2.0基因
KEGG GAP JUNCTION 90 68 该途径中的所有SZGR 2.0基因
BIOCARTA CK1 PATHWAY 17 17 该途径中的所有SZGR 2.0基因
GPCR的反应组信号传导 920 449 该途径中的所有SZGR 2.0基因
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 该途径中的所有SZGR 2.0基因
REACTOME AMINE LIGAND BINDING RECEPTORS 38 33 该途径中的所有SZGR 2.0基因
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 该途径中的所有SZGR 2.0基因
REACTOME G ALPHA S SIGNALLING EVENTS 121 82 该途径中的所有SZGR 2.0基因
Reactome GPCR配体结合 408 246 该途径中的所有SZGR 2.0基因
Pujana ATM PCC网络 1442 892 该途径中的所有SZGR 2.0基因
LOPES METHYLATED IN COLON CANCER DN 28 26 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
BRIDEAU IMPRINTED GENES 63 47 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

mirna家族 Target position mirna id miRNA seq
UTR start UTR end 匹配方法
mir-15/16/195/424/497 117 123 M8 hsa-miR-15a脑 UAGCAGCACAUAAUGGUUUGUG
HSA-MIR-16脑 uagcagcacguaaauauuggcg
hsa-miR-15b脑 UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
HSA-MIR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 cagcagcacacuguguuugu
miR-203.1 1060 1066 1A HSA-MIR-203 UGAAAUGUUUAGGACCACUAG
miR-216 693 699 M8 HSA-MIR-216 UAAUCUCAGCUGGCAACUGUG
miR-29 380 386 1A hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
mir-496 1028 1034 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-500 423 429 M8 hsa-miR-500 AUGCACCUGGGCAAGGAUUCUG
miR-539 1055 1061 1A hsa-miR-539 ggagaauuauccuuggugugu
miR-93.hd/291-3p/294/295/302/372/373/520 654 660 M8 hsa-miR-93脑 aaagugcuguucgugcagguag
HSA-MIR-302A UAAGUGCUUCCAUGUUUUGGUGA
HSA-MIR-302B UAAGUGCUUCCAUGUUUUAGUAG
HSA-MIR-302C uaagugcuuccauguucagugg
HSA-MIR-302D UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e Aaagugcuuuuuugaggg
HSA-MIR-520A AAAGUGCUUCCCUUUGGACUGU
HSA-MIR-520B AAAGUGCUUCCUUUUAGAGGG
HSA-MIR-520C AAAGUGCUUCCUUUUAGAGGGUU
HSA-MIR-520D AAAGUGCUUCUCUUUGGUGGGUU