Gene Page:drd2
概括？
| 基因 | 1813 |
| 象征 | drd2 |
| Synonyms | D2DR|D2R |
| Description | 多巴胺受体D2 |
| Reference | MIM：126450|HGNC:HGNC:3023|Ensembl：ENSG00000149295|HPRD：00539|Vega:OTTHUMG00000167717 |
| 基因类型 | 蛋白质编码 |
| Map location | 11q23 |
| pascal p-value | 1.601E-7 |
| 胎儿β | -0.638 |
| 主持人 | Myers' cis & trans |
| Support | GPCR信号传导 潜在的突触基因 |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| adt:Sun_2012 | 系统研究抗精神病药及其靶标 | A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes. | |
| 简历：Gwascat | Genome-wide Association Studies | 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。 | |
| CV:GWASdb | Genome-wide Association Studies | 精神分裂症的GWASDB记录 | |
| 简历：PGC128 | Genome-wide Association Study | A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| Association | A combined odds ratio method (Sun等。2008), association studies | 3 | Link to SZGene |
| GSMA_I | Genome scan meta-analysis | PSR：0.006 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypal | 点击显示详细信息 |
| go_annotation | 将与神经相关的关键字映射到基因本体论注释 | Hits with neuro-related keywords: 16 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 31 |
Section I. Genetics and epigenetics annotation
简历：PGC128
简历：PGC128| SNP ID | 染色体 | 位置 | Allele | p | 功能 | Gene | 向上/向下距离 |
|---|---|---|---|---|---|---|---|
| RS2514218 | Chr11 | 113392994 | TC | 4.091E-10 | 基因间 | DRD2，TMPRSS5 | dist=46993;dist=165274 |
eQTL annotation
| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | pvalue | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| RS2190759 | CHR17 | 55794698 | drd2 | 1813 | 0.08 | 反式 |
第二节。转录组注释
一般基因表达（GTEX）
基因表达在发展脉络(BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
No co-expressed genes in brain regions
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| GO:0004952 | 多巴胺受体活性 | IEA | Neurotransmitter, dopamine (GO term level: 8) | - |
| GO:0001670 | 多巴胺D2受体活性 | IDA | 多巴胺（GO期限：10） | 8301582 |
| GO:0004872 | receptor activity | IEA | - | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO:0048755 | 神经的分支形态发生 | ISS | 神经元（GO期限：6） | - |
| 去：0007416 | synaptogenesis | ISS | 突触（GO期限：6） | - |
| 去：0007409 | 轴突发生 | ISS | neuron, axon, neurite (GO term level: 12) | - |
| GO：0060160 | negative regulation of dopamine receptor signaling pathway | ISS | 多巴胺（GO期限：10） | - |
| GO：0060158 | 多巴胺受体，磷脂酶C激活途径 | IGI | 多巴胺（GO期限：10） | 17194762 |
| GO：0051586 | 多巴胺摄取的阳性调节 | ISS | 多巴胺（GO期限：12） | - |
| GO：0051967 | negative regulation of synaptic transmission, glutamatergic | ISS | neuron, glutamate, Synap, Neurotransmitter (GO term level: 10) | - |
| GO:0007270 | 神经障碍突触传播 | ISS | neuron, Synap (GO term level: 7) | - |
| GO：0048169 | 调节长期神经元突触可塑性 | ISS | 神经元，突触（GO期限：10） | - |
| GO:0032228 | 调节突触传播，GABA能量 | ISS | 神经元，GABA，突触，神经递质（GO术语级别：9） | - |
| GO：0021853 | cerebral cortex GABAergic interneuron migration | ISS | neuron, GABA (GO term level: 14) | - |
| GO：0042417 | 多巴胺代谢过程 | 我知道了 | Neurotransmitter, dopamine (GO term level: 8) | 8301582 |
| GO:0001659 | temperature homeostasis | ISS | - | |
| 去：0002052 | positive regulation of neuroblast proliferation | ISS | - | |
| 去：0002027 | regulation of heart rate | ISS | - | |
| 去：0002028 | 钠离子运输的调节 | ISS | - | |
| GO:0001975 | 对苯丙胺的反应 | ISS | - | |
| GO:0001976 | 通过神经过程调节全身动脉血压 | ISS | - | |
| GO:0007186 | G蛋白偶联受体蛋白信号通路 | IEA | - | |
| GO:0007165 | 信号转导 | IEA | - | |
| GO:0008285 | negative regulation of cell proliferation | ISS | - | |
| 去：0008306 | associative learning | ISS | - | |
| 去：0008542 | visual learning | ISS | - | |
| 去：0009416 | response to light stimulus | ISS | - | |
| 去：0007628 | adult walking behavior | ISS | - | |
| 去：0007626 | 运动行为 | ISS | - | |
| 去：0008104 | protein localization | ISS | - | |
| 去：0007608 | sensory perception of smell | ISS | - | |
| GO:0042493 | response to drug | ISS | - | |
| GO：0021984 | adenohypophysis development | ISS | - | |
| 去：0030432 | peristalsis | ISS | - | |
| 去：0051209 | release of sequestered calcium ion into cytosol | ISS | - | |
| GO：0030814 | 营地代谢过程的调节 | IDA | 8666994 | |
| 去：0030146 | diuresis | ISS | - | |
| 去：0030147 | 纳特里雷斯 | ISS | - | |
| GO：0032922 | circadian regulation of gene expression | ISS | - | |
| 去：0030384 | 磷酸肌醇代谢过程 | ISS | - | |
| 去：0030336 | 细胞迁移的负调节 | ISS | - | |
| GO:0043278 | response to morphine | ISS | - | |
| GO:0043266 | 钾离子运输的调节 | ISS | - | |
| GO：0048148 | 对可卡因的行为反应 | ISS | - | |
| GO：0048149 | 对乙醇的行为反应 | ISS | - | |
| GO:0050709 | 蛋白质分泌的阴性调节 | IDA | 16839358 | |
| GO：0050482 | 花生四烯酸分泌 | IDA | 8301582 | |
| GO：0060124 | positive regulation of growth hormone secretion | ISS | - | |
| GO：0045776 | 血压负调节 | ISS | - | |
| GO：0051898 | negative regulation of protein kinase B signaling cascade | ISS | - | |
| GO：0060134 | 抑制预抑制 | ISS | - | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO：0030425 | 树突 | ISS | 神经元，轴突，树突（GO期限：6） | - |
| GO：0030424 | 轴突 | ISS | neuron, axon, Neurotransmitter (GO term level: 6) | - |
| GO：0016021 | 膜不可或缺 | IEA | - | |
| 去：0005886 | plasma membrane | IEA | - |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| adora2a | adora2 |RDC8 |ha2ar | 腺苷A2A受体 | - | HPRD,BioGRID | 12804599 |
| CLIC6 | clic1l | 氯化物内通道6 | - | HPRD,BioGRID | 14499480 |
| drd2 | D2DR | D2R | 多巴胺受体D2 | D2S受体通过第四个跨膜段中的CYS126形成同型二聚体。 | 绑定 | 12496294 |
| EPB41 | 4.1r |El1 |他 | 红细胞膜蛋白条带4.1（椭圆细胞增多症1，rh-c-链接） | - | HPRD | 12181426 |
| EPB41L1 | 4.1n |DKFZP686H17242 |KIAA0338 |MGC11072 | erythrocyte membrane protein band 4.1-like 1 | - | HPRD,BioGRID | 12181426 |
| flna | ABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2 | Filamin A，α（肌动蛋白结合蛋白280） | 亲和力捕获 - 韦斯特恩 | Biogrid | 12181426 |
| flna | ABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2 | Filamin A，α（肌动蛋白结合蛋白280） | Dopamine receptor D2 interacts with filamin A. This interaction was modeled on a demonstrated interaction between human FLN-A and D2 from unspecified source. | 绑定 | 11320256 |
| flna | ABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2 | Filamin A，α（肌动蛋白结合蛋白280） | - | HPRD | 11911837 |
| FREQ | DKFZP761L1223 |flup |NCS-1 |NCS1 | 频率同源物（果蝇） | - | HPRD,BioGRID | 12351722 |
| FREQ | DKFZP761L1223 |flup |NCS-1 |NCS1 | 频率同源物（果蝇） | The D2 dopamine receptor interacts with NCS-1. | 绑定 | 12351722 |
| GNAI2 | GIP |gnai2b |H_LUCA15.1 |H_LUCA16.1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | - | HPRD | 10978845 |
| GNAI3 | 87U6 |FLJ26559 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | - | HPRD | 10978845 |
| GNAZ | - | 鸟嘌呤核苷酸结合蛋白（G蛋白），αZ多肽 | - | HPRD | 9166747 |
| KCNJ3 | GIRK1 | KGA | KIR3.1 | potassium inwardly-rectifying channel, subfamily J, member 3 | 亲和力捕获 - 韦斯特恩 | Biogrid | 12297500 |
| KCNJ5 | CIR |girk4 |katp1 |Kir3.4 | potassium inwardly-rectifying channel, subfamily J, member 5 | 亲和力捕获 - 韦斯特恩 | Biogrid | 12297500 |
| KCNJ6 | BIR1 | GIRK2 | KATP2 | KCNJ7 | KIR3.2 | MGC126596 | hiGIRK2 | potassium inwardly-rectifying channel, subfamily J, member 6 | - | HPRD,BioGRID | 12297500 |
| KCNJ9 | GIRK3 | KIR3.3 | potassium inwardly-rectifying channel, subfamily J, member 9 | - | HPRD | 12297500 |
| ppp1R9B | FLJ30345 |PPP1R6 |PPP1R9 |Spino |SPN | protein phosphatase 1, regulatory (inhibitor) subunit 9B | - | HPRD,BioGRID | 10391935 |
| SSTR5 | - | somatostatin receptor 5 | - | HPRD | 10753124 |
Section V. Pathway annotation
| 路径名 | 路径大小 | # SZGR 2.0 genes in pathway | 信息 |
|---|---|---|---|
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | All SZGR 2.0 genes in this pathway |
| KEGG GAP JUNCTION | 90 | 68 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CK1 PATHWAY | 17 | 17 | All SZGR 2.0 genes in this pathway |
| st g alpha i路径 | 35 | 29 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
| 反应组胺配体结合受体 | 38 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA I SIGNALLING EVENTS | 195 | 114 | All SZGR 2.0 genes in this pathway |
| Reactome GPCR配体结合 | 408 | 246 | All SZGR 2.0 genes in this pathway |
| pARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| deurig t细胞促进性白血病 | 368 | 234 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS D UP | 38 | 23 | All SZGR 2.0 genes in this pathway |
| XU HGF TARGETS REPRESSED BY AKT1 DN | 95 | 58 | All SZGR 2.0 genes in this pathway |
| MOHANKUMAR TLX1 TARGETS DN | 193 | 112 | All SZGR 2.0 genes in this pathway |
| GRUETZMANN PANCREATIC CANCER DN | 203 | 134 | All SZGR 2.0 genes in this pathway |
| Jazag TGFB1通过SMAD4 DN发出信号 | 66 | 38 | All SZGR 2.0 genes in this pathway |
| KIM MYCN AMPLIFICATION TARGETS UP | 92 | 64 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| Lee Calorie限制性新皮层 | 83 | 66 | All SZGR 2.0 genes in this pathway |
| 阿尔茨海默氏症疾病 | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| KAYO CALORIE RESTRICTION MUSCLE UP | 95 | 64 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| Meissner NPC HCP带有H3K27Me3 | 79 | 59 | All SZGR 2.0 genes in this pathway |
| Meissner Brain HCP带有H3K4ME3和H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| Mikkelsen NPC HCP带有H3K27ME3 | 341 | 243 | All SZGR 2.0 genes in this pathway |
| Mikkelsen MEF HCP带有H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
第六节。microRNA注释
| mirna家族 | Target position | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| miR-141/200a | 128 | 134 | M8 | HSA-MIR-141 | uaacacugucugugugugugaugg |
| hsa-miR-200a | UAACACUGUCUGGUAACGAUGU | ||||
| mir-214 | 978 | 984 | 1a | hsa-miR-214brain | ACAGCAGGCACAGACAGGCAG |
| mir-326 | 527 | 534 | 1A，M8 | hsa-miR-326 | CCUCUGGGCCCUUCCUCCAG |
| mir-9 | 289 | 296 | 1A，M8 | hsa-miR-9SZ | UCUUUGGUUAUCUAGCUGUAUGA |