Gene Page:DRD3

Summary?
GeneID 1814
Symbol DRD3
Synonyms D3DR|ETM1|FET1
Description dopamine receptor D3
Reference MIM:126451|HGNC:HGNC:3024|Ensembl:ENSG00000151577|HPRD:00540|Vega:OTTHUMG00000159334
Gene type protein-coding
Map location 3q13.3
Pascal p-value 0.351
Fetal beta -0.024

Gene in Data Sources
Gene set name Method of gene set Description Info
ADT:Sun_2012 Systematic Investigation of Antipsychotic Drugs and Their Targets A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 3 Link to SZGene
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.04359
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.04047
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypal Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 9
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0219

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AFF3 0.93 0.89
MFHAS1 0.92 0.91
GRIK3 0.91 0.92
LIMCH1 0.91 0.85
DOPEY2 0.90 0.88
ITSN1 0.89 0.85
FAM59A 0.89 0.88
TIAM2 0.89 0.83
TSHZ3 0.89 0.86
EML1 0.89 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SERPINB6 -0.66 -0.70
AF347015.31 -0.60 -0.76
COPZ2 -0.59 -0.72
HSD17B14 -0.59 -0.69
MT-CO2 -0.59 -0.75
FXYD1 -0.58 -0.74
HIGD1B -0.58 -0.75
IFI27 -0.58 -0.73
RHOC -0.58 -0.69
AF347015.27 -0.58 -0.73

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0001592 dopamine D3 receptor activity IEA dopamine (GO term level: 10) -
GO:0004872 receptor activity IEA -
GO:0005515 protein binding IEA -
GO:0008144 药物绑定 ISS -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0060161 positive regulation of dopamine receptor signaling pathway IEA dopamine (GO term level: 10) -
GO:0060160 negative regulation of dopamine receptor signaling pathway IEA dopamine (GO term level: 10) -
GO:0048715 negative regulation of oligodendrocyte differentiation IEA oligodendrocyte, Glial (GO term level: 12) -
GO:0051584 regulation of dopamine uptake IC Synap, Neurotransmitter, dopamine (GO term level: 11) 8301582
GO:0014059 regulation of dopamine secretion IEA dopamine (GO term level: 10) -
GO:0007195 dopamine receptor, adenylate cyclase inhibiting pathway IDA dopamine (GO term level: 12) 7907363|18424554
GO:0007191 dopamine receptor, adenylate cyclase activating pathway IEA dopamine (GO term level: 12) -
GO:0042417 dopamine metabolic process IC Neurotransmitter, dopamine (GO term level: 8) 8301582
GO:0002016 regulation of blood volume by renin-angiotensin IEA -
GO:0002031 G-protein coupled receptor internalization IDA 18424554
GO:0001975 response to amphetamine IEA -
GO:0007186 G-protein coupled receptor protein signaling pathway IEA -
GO:0007194 negative regulation of adenylate cyclase activity IDA 7907363
GO:0007165 signal transduction IEA -
GO:0008542 visual learning IEA -
GO:0007626 运动的行为 IEA -
GO:0006874 cellular calcium ion homeostasis IDA 7911712
GO:0042493 response to drug ISS -
GO:0050883 musculoskeletal movement, spinal reflex action IEA -
GO:0019216 regulation of lipid metabolic process IEA -
GO:0030814 regulation of cAMP metabolic process IDA 8666994
GO:0032922 circadian regulation of gene expression IEA -
GO:0043278 response to morphine IEA -
GO:0040014 regulation of multicellular organism growth IEA -
GO:0045840 positive regulation of mitosis ISS -
GO:0048148 behavioral response to cocaine IEA -
GO:0050709 negative regulation of protein secretion IDA 16839358
GO:0050482 arachidonic acid secretion IDA 8301582
GO:0045776 negative regulation of blood pressure IEA -
GO:0045471 response to ethanol IEA -
GO:0051898 negative regulation of protein kinase B signaling cascade IEA -
GO:0060134 prepulse inhibition IMP 18325483
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005624 membrane fraction IEA -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane IC 8301582

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CLIC6 CLIC1L chloride intracellular channel 6 - HPRD,BioGRID 14499480
EPB41 4.1R | EL1 | HE erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) - HPRD 12181426
EPB41L1 4.1N | DKFZp686H17242 | KIAA0338 | MGC11072 erythrocyte membrane protein band 4.1-like 1 - HPRD,BioGRID 12181426
EPB41L2 4.1-G | DKFZp781D1972 | DKFZp781H1755 erythrocyte membrane protein band 4.1-like 2 - HPRD 12181426
FLNA ABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2 filamin A, alpha (actin binding protein 280) 多巴胺D3受体与细丝蛋白a Thi交互s interaction was modeled on a demonstrated interaction between human FLN-A and D3 from unspecified source. BIND 11320256
FLNA ABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2 filamin A, alpha (actin binding protein 280) - HPRD,BioGRID 11911837
FREQ DKFZp761L1223 | FLUP | NCS-1 | NCS1 frequenin homolog (Drosophila) Affinity Capture-Western BioGRID 12351722
FREQ DKFZp761L1223 | FLUP | NCS-1 | NCS1 frequenin homolog (Drosophila) The D3 dopamine receptor interacts with NCS-1. BIND 12351722
GIPC1 C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2 GIPC PDZ domain containing family, member 1 Two-hybrid BioGRID 14499480
GNAI1 Gi guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 - HPRD 10978845
GRB2 ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 growth factor receptor-bound protein 2 D3 interacts with Grb2. BIND 9843378
GRB2 ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 growth factor receptor-bound protein 2 - HPRD,BioGRID 11384839
MPDZ DKFZp781P216 | FLJ25909 | FLJ34626 | FLJ90240 | MUPP1 multiple PDZ domain protein - HPRD,BioGRID 14499480
NCK1 MGC12668 | NCK | NCKalpha NCK adaptor protein 1 D3 interacts with Nck. BIND 9843378
RDX DFNB24 radixin Two-hybrid BioGRID 14499480


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS 38 33 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195 114 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN 148 102 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN 123 76 All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER WITH H3K27ME3 196 93 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway