Gene Page:DRD5

Summary?
GeneID 1816
Symbol DRD5
Synonyms DBDR|DRD1B|DRD1L2
Description dopamine receptor D5
Reference MIM:126453|HGNC:HGNC:3026|Ensembl:ENSG00000169676|HPRD:00542|Vega:OTTHUMG00000128489
Gene type protein-coding
Map location 4p16.1
Pascal p-value 0.039
Sherlock p-value 0.761
Fetal beta -2.75
eGene Myers' cis & trans
Support DOPAMINE

Gene in Data Sources
Gene set name Method of gene set Description Info
ADT:Sun_2012 Systematic Investigation of Antipsychotic Drugs and Their Targets A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 2 Link to SZGene
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 5

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7142486 chr14 84504067 DRD5 1816 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC110491.1 0.60 0.47
CRYBG3 0.60 0.51
CFTR 0.58 0.45
DLC1 0.57 0.46
RHOQ 0.56 0.44
ANO3 0.55 0.45
SLC1A2 0.55 0.39
TJP1 0.54 0.52
SCN4B 0.54 0.42
ITGAV 0.54 0.43
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RPL35 -0.31 -0.41
RPL36 -0.30 -0.41
RPS7 -0.29 -0.34
PFDN5 -0.29 -0.34
BCL7C -0.29 -0.37
RPLP1 -0.28 -0.37
RPS14 -0.28 -0.34
FAU -0.28 -0.36
RPL31 -0.28 -0.35
SCNM1 -0.28 -0.30

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0001588 dopamine receptor coupled via Gs TAS Neurotransmitter, dopamine (GO term level: 9) 9457173
GO:0004872 receptor activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0060158 多巴胺受体,磷脂酶C激活路径way TAS dopamine (GO term level: 10) 9457173
GO:0007268 synaptic transmission NAS neuron, Synap, Neurotransmitter (GO term level: 6) 7727453
GO:0007191 dopamine receptor, adenylate cyclase activating pathway IDA dopamine (GO term level: 12) 1826762
GO:0001963 synaptic transmission, dopaminergic NAS neuron, Synap, Neurotransmitter, dopamine (GO term level: 8) 11036203
GO:0007190 activation of adenylate cyclase activity TAS 9457173
GO:0007186 G-protein coupled receptor protein signaling pathway IEA -
GO:0007165 signal transduction IEA -
GO:0006800 oxygen and reactive oxygen species metabolic process IDA 16352863
GO:0006874 cellular calcium ion homeostasis TAS 9457173
GO:0033861 negative regulation of NAD(P)H oxidase activity IDA 16352863
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005886 plasma membrane IDA 10531415|11500503
GO:0005887 integral to plasma membrane NAS 1826762

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS 38 33 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 121 82 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 142 96 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162 104 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147 101 All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146 104 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP 85 50 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
ZWANG DOWN BY 2ND EGF PULSE 293 119 All SZGR 2.0 genes in this pathway