创e Page:JAG1

Summary?
创eID 182
Symbol JAG1
Synonyms AGS|AHD|AWS|CD339|HJ1|JAGL1
Description jagged 1
Reference MIM:601920|HGNC:HGNC:6188|Ensembl:ENSG00000101384|HPRD:03562|Vega:OTTHUMG00000031872
创e type protein-coding
Map location 20p12.1-p11.23
Pascal p-value 0.311
Sherlock p-value 0.29
Fetal beta 0.26
DMG 2 (# studies)
eGene Meta
Support Ascano FMRP targets

基因数据urces
创e set name Method of gene set Description Info
CV:PGCnp 创ome-wide Association Study GWAS
DMG:Jaffe_2016 创ome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014 创ome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I 创ome scan meta-analysis Psr: 0.046
Expression Meta-analysis of gene expression Pvalue: 1.469
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg24652271 20 10654705 JAG1 1.594E-4 -0.236 0.032 DMG:Wockner_2014
cg08402873 20 10653164 JAG1 4.75E-10 -0.022 8.35E-7 DMG:Jaffe_2016


Section II. Transcriptome annotation

创eral gene expression (GTEx)

Not available

创e expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

创e expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
创e Pearson's Correlation Spearman's Correlation
GPR126 0.64 0.38
BCL2 0.58 0.33
CCDC90A 0.58 0.38
PCSK9 0.58 0.37
LRCH1 0.56 0.36
AC016138.1 0.55 0.36
CBLB 0.54 0.40
SEMA3E 0.54 0.26
RNF182 0.53 0.43
KLHL32 0.53 0.27
Top 10 negatively co-expressed genes
创e Pearson's Correlation Spearman's Correlation
AC018755.7 -0.34 -0.36
NFKBIB -0.33 -0.31
ATG16L2 -0.30 -0.23
ASPHD1 -0.29 -0.29
CCNI2 -0.29 -0.30
ZNF385A -0.29 -0.31
AC024575.3 -0.29 -0.31
HLA-F -0.28 -0.30
SLC9A3R2 -0.28 -0.26
MT-CO2 -0.28 -0.33

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005112 Notch binding IEA -
GO:0005112 Notch binding NAS 9268641
GO:0005509 calcium ion binding IEA -
GO:0005509 calcium ion binding NAS -
GO:0005515 protein binding IEA -
GO:0005198 structural molecule activity NAS 10679295
GO:0008083 growth factor activity NAS 11067884
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007399 nervous system development NAS neurite (GO term level: 5) 8923452
GO:0001525 angiogenesis NAS 8955070
GO:0001709 cell fate determination NAS 9207788
GO:0002011 morphogenesis of an epithelial sheet IEA -
GO:0007154 cell communication IEA -
GO:0009887 organ morphogenesis IEA -
GO:0007275 multicellular organismal development NAS -
GO:0042127 regulation of cell proliferation NAS 10329626
GO:0030216 keratinocyte differentiation NAS 12107827
GO:0030334 regulation of cell migration NAS 11549580
GO:0030097 hemopoiesis NAS 10329626
GO:0042491 auditory receptor cell differentiation IEA -
GO:0045639 positive regulation of myeloid cell differentiation IEA -
GO:0045747 positive regulation of Notch signaling pathway IEA -
GO:0045596 negative regulation of cell differentiation IEA -
GO:0045445 myoblast differentiation NAS 10329626
GO:0045446 endothelial cell differentiation NAS 10329626
GO:0048839 inner ear development IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region NAS 11427524
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane NAS 11427524

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NOTCH SIGNALING PATHWAY 47 35 所有SZGR 2.0基因通路
BIOCARTA PTDINS PATHWAY 23 16 所有SZGR 2.0基因通路
PID NOTCH PATHWAY 59 49 所有SZGR 2.0基因通路
PID TAP63 PATHWAY 54 40 所有SZGR 2.0基因通路
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 27 18 所有SZGR 2.0基因通路
REACTOME SIGNALING BY NOTCH4 12 10 所有SZGR 2.0基因通路
REACTOME SIGNALING BY NOTCH2 12 10 所有SZGR 2.0基因通路
REACTOME SIGNALING BY NOTCH1 70 46 所有SZGR 2.0基因通路
REACTOME SIGNALING BY NOTCH3 12 10 所有SZGR 2.0基因通路
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 12 8 所有SZGR 2.0基因通路
REACTOME SIGNALING BY NOTCH 103 64 所有SZGR 2.0基因通路
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 所有SZGR 2.0基因通路
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177 110 所有SZGR 2.0基因通路
LIU CMYB TARGETS UP 165 106 所有SZGR 2.0基因通路
LIU VMYB TARGETS UP 127 78 所有SZGR 2.0基因通路
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 所有SZGR 2.0基因通路
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 所有SZGR 2.0基因通路
HORIUCHI WTAP TARGETS UP 306 188 所有SZGR 2.0基因通路
WANG CLIM2 TARGETS DN 186 114 所有SZGR 2.0基因通路
JAEGER METASTASIS DN 258 141 所有SZGR 2.0基因通路
DITTMER PTHLH TARGETS UP 112 68 所有SZGR 2.0基因通路
SENESE HDAC2 TARGETS DN 133 77 所有SZGR 2.0基因通路
TIEN INTESTINE PROBIOTICS 24HR DN 214 133 所有SZGR 2.0基因通路
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 所有SZGR 2.0基因通路
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 所有SZGR 2.0基因通路
GOZGIT ESR1 TARGETS DN 781 465 所有SZGR 2.0基因通路
LIU CDX2 TARGETS UP 36 22 所有SZGR 2.0基因通路
LINDGREN BLADDER CANCER CLUSTER 3 DN 229 142 所有SZGR 2.0基因通路
MCBRYAN PUBERTAL BREAST 4 5WK DN 196 131 所有SZGR 2.0基因通路
MCBRYAN PUBERTAL BREAST 6 7WK UP 197 135 所有SZGR 2.0基因通路
HAMAI APOPTOSIS VIA TRAIL UP 584 356 所有SZGR 2.0基因通路
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169 127 所有SZGR 2.0基因通路
KAN RESPONSE TO ARSENIC TRIOXIDE 123 80 所有SZGR 2.0基因通路
DARWICHE SKIN TUMOR PROMOTER DN 185 115 所有SZGR 2.0基因通路
DARWICHE PAPILLOMA RISK LOW UP 162 104 所有SZGR 2.0基因通路
DARWICHE PAPILLOMA RISK HIGH UP 147 101 所有SZGR 2.0基因通路
DARWICHE SQUAMOUS CELL CARCINOMA UP 146 104 所有SZGR 2.0基因通路
PEREZ TP63 TARGETS 355 243 所有SZGR 2.0基因通路
SCHLOSSER SERUM RESPONSE DN 712 443 所有SZGR 2.0基因通路
LI CISPLATIN RESISTANCE DN 35 20 所有SZGR 2.0基因通路
SNIJDERS AMPLIFIED IN HEAD AND NECK TUMORS 37 27 所有SZGR 2.0基因通路
BEGUM TARGETS OF PAX3 FOXO1 FUSION AND PAX3 7 5 所有SZGR 2.0基因通路
SASAKI TARGETS OF TP73 AND TP63 11 7 所有SZGR 2.0基因通路
HASINA NOL7 TARGETS DN 13 9 所有SZGR 2.0基因通路
SHETH LIVER CANCER VS TXNIP LOSS PAM5 94 59 所有SZGR 2.0基因通路
GROSS HYPOXIA VIA ELK3 DN 156 106 所有SZGR 2.0基因通路
GROSS HYPOXIA VIA ELK3 AND HIF1A UP 142 104 所有SZGR 2.0基因通路
NUYTTEN EZH2 TARGETS DN 1024 594 所有SZGR 2.0基因通路
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 所有SZGR 2.0基因通路
KOYAMA SEMA3B TARGETS DN 411 249 所有SZGR 2.0基因通路
WU CELL MIGRATION 184 114 所有SZGR 2.0基因通路
AMIT EGF RESPONSE 120 HELA 69 47 所有SZGR 2.0基因通路
ONDER CDH1 TARGETS 1 DN 169 102 所有SZGR 2.0基因通路
ROZANOV MMP14 CORRELATED 11 9 所有SZGR 2.0基因通路
ROZANOV MMP14 TARGETS UP 266 171 所有SZGR 2.0基因通路
ROSS AML WITH PML RARA FUSION 77 62 所有SZGR 2.0基因通路
SHEPARD CRUSH AND BURN MUTANT DN 185 111 所有SZGR 2.0基因通路
ALCALAY AML BY NPM1 LOCALIZATION UP 140 83 所有SZGR 2.0基因通路
VERHAAK AML WITH NPM1 MUTATED UP 183 111 所有SZGR 2.0基因通路
SESTO RESPONSE TO UV C2 54 39 所有SZGR 2.0基因通路
SESTO RESPONSE TO UV C5 46 36 所有SZGR 2.0基因通路
WANG SMARCE1 TARGETS UP 280 183 所有SZGR 2.0基因通路
MARTINEZ RESPONSE TO TRABECTEDIN DN 271 175 所有SZGR 2.0基因通路
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 所有SZGR 2.0基因通路
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 所有SZGR 2.0基因通路
FOSTER TOLERANT MACROPHAGE UP 156 92 所有SZGR 2.0基因通路
海勒HDAC目标被甲基化 461 298 所有SZGR 2.0基因通路
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 所有SZGR 2.0基因通路
RIZKI TUMOR INVASIVENESS 3D DN 270 181 所有SZGR 2.0基因通路
RIGGI EWING SARCOMA PROGENITOR UP 430 288 所有SZGR 2.0基因通路
HUANG FOXA2 TARGETS UP 45 28 所有SZGR 2.0基因通路
IZADPANAH STEM CELL ADIPOSE VS BONE UP 126 92 所有SZGR 2.0基因通路
ZHENG GLIOBLASTOMA PLASTICITY UP 250 168 所有SZGR 2.0基因通路
LABBE TGFB1 TARGETS UP 102 64 所有SZGR 2.0基因通路
LABBE TARGETS OF TGFB1 AND WNT3A UP 111 70 所有SZGR 2.0基因通路
WEST ADRENOCORTICAL TUMOR UP 294 199 所有SZGR 2.0基因通路
CLIMENT BREAST CANCER COPY NUMBER UP 23 20 所有SZGR 2.0基因通路
LU TUMOR ANGIOGENESIS UP 25 22 所有SZGR 2.0基因通路
LIN TUMOR ESCAPE FROM IMMUNE ATTACK 18 12 所有SZGR 2.0基因通路
HUANG DASATINIB RESISTANCE UP 81 53 所有SZGR 2.0基因通路
HUPER BREAST BASAL VS LUMINAL UP 54 29 所有SZGR 2.0基因通路
JIANG TIP30 TARGETS UP 46 28 所有SZGR 2.0基因通路
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 所有SZGR 2.0基因通路
YOSHIMURA MAPK8 TARGETS DN 366 257 所有SZGR 2.0基因通路
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 所有SZGR 2.0基因通路
RUTELLA RESPONSE TO HGF UP 418 282 所有SZGR 2.0基因通路
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245 150 所有SZGR 2.0基因通路
CHANG CORE SERUM RESPONSE DN 209 137 所有SZGR 2.0基因通路
BRUNEAU HEART GREAT VESSELS AND VALVULOGENESIS 8 8 所有SZGR 2.0基因通路
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 所有SZGR 2.0基因通路
ZHAN LATE DIFFERENTIATION GENES UP 33 24 所有SZGR 2.0基因通路
VALK AML CLUSTER 2 29 14 所有SZGR 2.0基因通路
COULOUARN TEMPORAL TGFB1 SIGNATURE DN 138 99 所有SZGR 2.0基因通路
WOO LIVER CANCER RECURRENCE UP 105 75 所有SZGR 2.0基因通路
SCHOEN NFKB SIGNALING 34 26 所有SZGR 2.0基因通路
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 所有SZGR 2.0基因通路
CHICAS RB1 TARGETS CONFLUENT 567 365 所有SZGR 2.0基因通路
FUKUSHIMA TNFSF11 TARGETS 16 14 所有SZGR 2.0基因通路
JOHNSTONE PARVB TARGETS 3 UP 430 288 所有SZGR 2.0基因通路
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 所有SZGR 2.0基因通路
PASINI SUZ12 TARGETS DN 315 215 所有SZGR 2.0基因通路
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP 121 70 所有SZGR 2.0基因通路
LEE BMP2 TARGETS UP 745 475 所有SZGR 2.0基因通路
WINZEN DEGRADED VIA KHSRP 100 70 所有SZGR 2.0基因通路
IKEDA MIR1 TARGETS UP 53 39 所有SZGR 2.0基因通路
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403 240 所有SZGR 2.0基因通路
PLASARI TGFB1 TARGETS 10HR UP 199 143 所有SZGR 2.0基因通路
LIU IL13 PRIMING MODEL 15 11 所有SZGR 2.0基因通路
PHONG TNF RESPONSE VIA P38 COMPLETE 227 151 所有SZGR 2.0基因通路
PECE MAMMARY STEM CELL UP 146 75 所有SZGR 2.0基因通路
PECE MAMMARY STEM CELL DN 146 88 所有SZGR 2.0基因通路
LIM MAMMARY STEM CELL UP 489 314 所有SZGR 2.0基因通路
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222 159 所有SZGR 2.0基因通路

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 1309 1316 1A,m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 1309 1315 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-129-5p 196 202 m8 hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-140 443 449 1A hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-141/200a 1428 1434 1A hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-153 192 199 1A,m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-186 601 607 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-21 1234 1241 1A,m8 hsa-miR-21brain UAGCUUAUCAGACUGAUGUUGA
hsa-miR-590 GAGCUUAUUCAUAAAAGUGCAG
miR-224 90 96 1A hsa-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-26 1248 1255 1A,m8 hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-335 365 371 1A hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
miR-34/449 1302 1308 m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-34b 1303 1309 m8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-377 1105 1112 1A,m8 hsa-miR-377 AUCACACAAAGGCAACUUUUGU
hsa-miR-377 AUCACACAAAGGCAACUUUUGU
miR-381 379 385 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-421 921 927 1A hsa-miR-421 GGCCUCAUUAAAUGUUUGUUG
miR-448 193 199 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-450 196 202 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA
miR-485-3p 1511 1518 1A,m8 hsa-miR-485-3p GUCAUACACGGCUCUCCUCUCU
miR-496 592 598 1A hsa-miR-496 AUUACAUGGCCAAUCUC