Gene Page:EPYC
Summary?
| GeneID | 1833 |
| Symbol | EPYC |
| Synonyms | DSPG3|PGLB|Pg-Lb|SLRR3B |
| Description | epiphycan |
| Reference | MIM:601657|HGNC:HGNC:3053|Ensembl:ENSG00000083782|HPRD: 15988|Vega:OTTHUMG00000170072 |
| Gene type | protein-coding |
| Map location | 12q21 |
| Pascal p-value | 0.356 |
| Fetal beta | -0.517 |
| 支持 | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| 认为:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
认为table
认为table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EPYC | chr12 | 91365717 | G | A | NM_004950 | p.188R>* | nonsense | Schizophrenia | 认为:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HTR5A | 0.92 | 0.91 |
| CTSB | 0.92 | 0.91 |
| SULT4A1 | 0.92 | 0.93 |
| AC005277.1 | 0.91 | 0.93 |
| NDRG3 | 0.91 | 0.93 |
| NPTN | 0.91 | 0.93 |
| SERINC3 | 0.91 | 0.93 |
| PTPRN | 0.91 | 0.89 |
| NMT1 | 0.91 | 0.91 |
| SYNGR1 | 0.91 | 0.94 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCL7C | -0.47 | -0.51 |
| AC011475.1 | -0.46 | -0.52 |
| FAM36A | -0.44 | -0.39 |
| GTF3C6 | -0.44 | -0.42 |
| RAB13 | -0.43 | -0.50 |
| GPR125 | -0.42 | -0.34 |
| RBMX2 | -0.42 | -0.41 |
| C9orf46 | -0.42 | -0.41 |
| C21orf57 | -0.41 | -0.43 |
| AC005921.3 | -0.41 | -0.55 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SHETH LIVER CANCER VS TXNIP LOSS PAM5 | 94 | 59 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR | 681 | 420 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER ERBB2 UP | 147 | 83 | All SZGR 2.0 genes in this pathway |
| POOLA INVASIVE BREAST CANCER UP | 288 | 168 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |
| ANASTASSIOU CANCER MESENCHYMAL TRANSITION SIGNATURE | 64 | 40 | All SZGR 2.0 genes in this pathway |
| NABA PROTEOGLYCANS | 35 | 23 | All SZGR 2.0 genes in this pathway |
| NABA CORE MATRISOME | 275 | 148 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |