Gene Page:EDA

Summary?
GeneID 1896
Symbol EDA
Synonyms ECTD1|ED1|ED1-A1|ED1-A2|EDA-A1|EDA-A2|EDA1|EDA2|HED|HED1|ODT1|STHAGX1|TNLG7C|XHED|XLHED
Description ectodysplasin A
Reference MIM:300451|HGNC:HGNC:3157|Ensembl:ENSG00000158813|HPRD:02347|Vega:OTTHUMG00000021764
Gene type protein-coding
Map location Xq12-q13.1
Fetal beta 1.25

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypal Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
LAMA4 0.76 0.73
ETS1 0.73 0.78
LAMC1 0.71 0.70
FN1 0.71 0.71
VCL 0.69 0.70
PCDH18 0.69 0.70
FLVCR2 0.69 0.59
NID1 0.69 0.64
ELK3 0.68 0.72
OLFML3 0.68 0.63
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FXYD1 -0.39 -0.36
AF347015.21 -0.39 -0.38
MT-CO2 -0.37 -0.40
S100A13 -0.36 -0.34
MT1G -0.36 -0.34
AC098691.2 -0.35 -0.36
APOC1 -0.34 -0.30
AF347015.31 -0.34 -0.37
CA5A -0.34 -0.32
AF347015.8 -0.34 -0.37

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005102 receptor binding IDA Neurotransmitter (GO term level: 4) 11039935
GO:0005164 tumor necrosis factor receptor binding IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0001942 hair follicle development IEA -
GO:0007160 cell-matrix adhesion IEA -
GO:0007398 ectoderm development TAS 8696334
GO:0007165 signal transduction TAS 8696334
GO:0007431 salivary gland development IEA -
GO:0006955 immune response IEA -
GO:0007275 multicellular organismal development IEA -
GO:0042346 positive regulation of NF-kappaB import into nucleus IEA -
GO:0030154 cell differentiation IEA -
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 11039935
GO:0042475 odontogenesis of dentine-containing tooth IEA -
GO:0043473 pigmentation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005856 cytoskeleton TAS 10484778
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005576 extracellular region IEA -
GO:0005624 membrane fraction TAS 8696334
GO:0005886 plasma membrane TAS 9736768|10484778
GO:0005887 integral to plasma membrane IEA -
GO:0045177 apical part of cell IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 2.0所有SZGR基因pathway
PARENT MTOR SIGNALING UP 567 375 2.0所有SZGR基因pathway
ODONNELL METASTASIS UP 82 58 2.0所有SZGR基因pathway
WANG PROSTATE CANCER ANDROGEN INDEPENDENT 66 37 2.0所有SZGR基因pathway
BROWNE HCMV INFECTION 20HR UP 240 152 2.0所有SZGR基因pathway
MITSIADES RESPONSE TO APLIDIN DN 249 165 2.0所有SZGR基因pathway
WANG MLL TARGETS 289 188 2.0所有SZGR基因pathway
DURAND STROMA S UP 297 194 2.0所有SZGR基因pathway
NABA SECRETED FACTORS 344 197 2.0所有SZGR基因pathway
NABA MATRISOME ASSOCIATED 753 411 2.0所有SZGR基因pathway
NABA MATRISOME 1028 559 2.0所有SZGR基因pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 845 851 m8 hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-130/301 313 320 1A,m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-149 46 52 m8 hsa-miR-149brain UCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/497 72 78 m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-150 42 48 m8 hsa-miR-150 UCUCCCAACCCUUGUACCAGUG
miR-22 627 633 m8 hsa-miR-22brain AAGCUGCCAGUUGAAGAACUGU
miR-24 3039 3046 1A,m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-324-5p 3142 3148 1A hsa-miR-324-5p CGCAUCCCCUAGGGCAUUGGUGU
miR-342 3748 3755 1A,m8 hsa-miR-342brain UCUCACACAGAAAUCGCACCCGUC