Gene Page:EDN1

Summary?
GeneID 1906
Symbol EDN1
Synonyms ARCND3|ET1|HDLCQ7|PPET1|QME
Description endothelin 1
Reference MIM:131240|HGNC:HGNC:3176|Ensembl:ENSG00000078401|HPRD:07030|Vega:OTTHUMG00000014266
Gene type protein-coding
Map location 6p24.1
Pascal p-value 0.247
Sherlock p-value 0.504
Fetal beta -0.167
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0159
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg16537245 6 12290035 EDN1 2.55E-5 -0.491 0.017 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17077510 chr3 45294294 EDN1 1906 0.16 trans
rs16933426 chr10 78113005 EDN1 1906 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005179 hormone activity IDA 2649896|10770212
GO:0031707 endothelin A receptor binding IEA -
GO:0031708 endothelin B receptor binding IDA 10770212
GO:0031708 endothelin B receptor binding 新闻学会 1713452
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0043179 rhythmic excitation IEA Synap (GO term level: 9) -
GO:0001569 patterning of blood vessels IEA -
GO:0001666 response to hypoxia IEA -
GO:0001701 in utero embryonic development IEA -
GO:0003100 regulation of systemic arterial blood pressure by endothelin IDA 2649896
GO:0007205 activation of protein kinase C activity IEA -
GO:0008217 regulation of blood pressure IEA -
GO:0007267 cell-cell signaling IDA 12379507
GO:0010595 积极调节内皮细胞迁移 TAS 8999856
GO:0009953 dorsal/ventral pattern formation IEA -
GO:0030195 negative regulation of blood coagulation TAS 16820593
GO:0048016 inositol phosphate-mediated signaling IDA 1917960
GO:0030072 peptide hormone secretion IDA 10770212
GO:0007507 heart development IEA -
GO:0007585 respiratory gaseous exchange IEA -
GO:0014032 neural crest cell development IEA -
GO:0015758 glucose transport IEA -
GO:0010460 positive regulation of heart rate IDA 2649896
GO:0006885 regulation of pH IEA -
GO:0014065 phosphoinositide 3-kinase cascade IDA 17078114
GO:0019722 calcium-mediated signaling IDA 1917960|10770212
GO:0042313 protein kinase C deactivation IDA 16820593
GO:0014824 artery smooth muscle contraction TAS 1725334
GO:0043507 positive regulation of JNK activity IDA 12847114
GO:0042474 middle ear morphogenesis IEA -
GO:0051216 cartilage development IEA -
GO:0019229 regulation of vasoconstriction IEA -
GO:0030818 negative regulation of cAMP biosynthetic process IEA -
GO:0031583 G-protein signaling, phospholipase D activating pathway IEA -
GO:0030146 diuresis IEA -
GO:0030147 natriuresis IEA -
GO:0030185 nitric oxide transport IDA 16820593
GO:0045321 leukocyte activation TAS 16820593
GO:0045840 positive regulation of mitosis IDA 10770212
GO:0046887 positive regulation of hormone secretion IDA 10770212
GO:0045793 positive regulation of cell size IDA 12847114
GO:0045987 positive regulation of smooth muscle contraction IEA -
GO:0048514 blood vessel morphogenesis IEA -
GO:0048661 positive regulation of smooth muscle cell proliferation IDA 10393673
GO:0045429 positive regulation of nitric oxide biosynthetic process TAS 8999856
GO:0051482 elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) IEA -
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process IDA 16820593
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -
GO:0005615 extracellular space IEA -
GO:0005737 cytoplasm IDA 12379507

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
BIOCARTA HIF PATHWAY 15 12 All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 56 45 All SZGR 2.0 genes in this pathway
BIOCARTA CARDIACEGF PATHWAY 18 16 All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 63 52 All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 70 60 All SZGR 2.0 genes in this pathway
PID HIF1 TFPATHWAY 66 52 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188 108 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241 146 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP 85 54 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260 143 All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS DN 133 77 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176 123 All SZGR 2.0 genes in this pathway
NAGASHIMA EGF SIGNALING UP 58 40 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 118 78 All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS DN 49 33 All SZGR 2.0 genes in this pathway
DEBOSSCHER NFKB TARGETS REPRESSED BY GLUCOCORTICOIDS 24 18 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 127 92 All SZGR 2.0 genes in this pathway
SASAI RESISTANCE TO NEOPLASTIC TRANSFROMATION 50 31 All SZGR 2.0 genes in this pathway
WILLIAMS ESR2 TARGETS DN 11 6 All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS UP 27 16 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156 106 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 110 78 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP 142 104 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT UP 21 19 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP 69 55 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 120 MCF10A 65 44 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223 140 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169 102 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 3 DN 59 32 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP 118 66 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP 64 40 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207 145 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA LB UP 48 28 All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA 81 64 All SZGR 2.0 genes in this pathway
CHUANG OXIDATIVE STRESS RESPONSE UP 28 18 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 88 58 All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS 36 32 All SZGR 2.0 genes in this pathway
CLASPER LYMPHATIC VESSELS DURING METASTASIS UP 20 12 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS 212 121 All SZGR 2.0 genes in this pathway
SANSOM WNT PATHWAY REQUIRE MYC 58 43 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
LU TUMOR ANGIOGENESIS UP 25 22 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242 168 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
SCHOEN NFKB SIGNALING 34 26 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
DELPUECH FOXO3 TARGETS UP 68 49 All SZGR 2.0 genes in this pathway
WIEDERSCHAIN TARGETS OF BMI1 AND PCGF2 57 39 All SZGR 2.0 genes in this pathway
WINZEN DEGRADED VIA KHSRP 100 70 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
IKEDA MIR1 TARGETS UP 53 39 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA VIA KDM3A 53 34 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP 289 184 All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222 159 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 143 150 1A,m8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-125/351 388 394 1A hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain UCCCUGAGACCCUUUAACCUGUG
miR-203.1 383 390 1A,m8 hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-378* 404 410 m8 hsa-miR-422b CUGGACUUGGAGUCAGAAGGCC
hsa-miR-422a CUGGACUUAGGGUCAGAAGGCC
miR-409-3p 142 148 m8 hsa-miR-409-3p CGAAUGUUGCUCGGUGAACCCCU
miR-455 380 386 m8 hsa-miR-455 UAUGUGCCUUUGGACUACAUCG