SZGR2 - Beplay体育中心

概括?

GeneID	1915
Symbol	EEF1A1
Synonyms	CCS-3\|CCS3\|EE1A1\|EEF-1\|EEF1A\|EF-Tu\|EF1A\|GRAF-1EF\|HNGC:16303\|LENG7\|PTI1\|eEF1A-1
Description	eukaryotic translation elongation factor 1 alpha 1
Reference	MIM:130590\|HGNC:HGNC:3189\|Ensembl:ENSG00000156508\|HPRD:00559\|
Gene type	protein-coding
Map location	6q14.1
Pascal p-value	0.85
Sherlock P值	0.003
Fetal beta	0.715
Support	RNA AND PROTEIN SYNTHESIS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS COMPOSITESET

数据源中的基因

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
Network	人蛋白蛋白质相互作用网络中核心基因的最短路径距离	Contribution to shortest path in PPI network: 0.2361

第一节遗传学和表观遗传学注释

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	核苷酸结合	IEA		-
去：0003746	translation elongation factor activity	IEA		-
去：0003746	translation elongation factor activity	NAS		3570288
GO:0003924	GTPase活性	IEA		-
GO:0003924	GTPase活性	NAS		3570288
GO:0005515	protein binding	IPI		15231747\|17373842
GO:0005525	GTP binding	IEA		-
GO:0005525	GTP binding	塔斯		3512269
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006414	translational elongation	EXP		15189156
GO:0006414	translational elongation	IEA		-
GO:0006414	translational elongation	NAS		3570288
GO:0006414	translational elongation	塔斯		8812466
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
去：0005829	cytosol	EXP		10368288
GO:0005853	真核翻译伸长因子1复合物	塔斯		2564392
GO:0005737	细胞质	IEA		-
GO:0005737	细胞质	NAS		-
GO:0005737	细胞质	塔斯		3512269

第四节。蛋白质蛋白相互作用注释

Interactors	Aliases B	Official full name B	Experimental	资源	PubMed ID
ANKRD24	KIAA1981	ankyrin repeat domain 24	两个杂交	BioGRID	16169070
ARIH2	ARI2 \| FLJ10938 \| FLJ33921 \| TRIAD1	Ariadne同源2（果蝇）	两个杂交	BioGRID	16169070
axin1	AXIN \| MGC52315	axin 1	两个杂交	BioGRID	16169070
BRMS1	DKFZp564A063	乳腺癌转移抑制剂1	两个杂交	BioGRID	16169070
BTBD2	-	BTB (POZ) domain containing 2	两个杂交	BioGRID	16169070
C11orf59	FLJ20625	chromosome 11 open reading frame 59	两个杂交	BioGRID	16169070
C11orf79	FLJ20487	chromosome 11 open reading frame 79	两个杂交	BioGRID	16169070
C4B	C4A \| C4A13 \| C4A91 \| C4B1 \| C4B12 \| C4B2 \| C4B3 \| C4B5 \| C4F \| CH \| CO4 \| CPAMD3 \| FLJ60561 \| MGC164979	complement component 4B (Childo blood group)	-	HPRD,BioGRID	10851272
CCDC130	MGC10471	coiled-coil domain containing 130	两个杂交	BioGRID	16169070
CCL18	AMAC-1 \| AMAC1 \| CKb7 \| DC-CK1 \| DCCK1 \| MIP-4 \| PARC \| SCYA18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	两个杂交	BioGRID	16169070
CKS2	CKSHS2	CDC28 protein kinase regulatory subunit 2	两个杂交	BioGRID	16169070
COX17	MGC104397 \| MGC117386	COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)	两个杂交	BioGRID	16169070
CRADD	MGC9163 \| RAIDD	CASP2 and RIPK1 domain containing adaptor with death domain	两个杂交	BioGRID	16169070
CRCT1	C1orf42 \| NICE-1	cysteine-rich C-terminal 1	两个杂交	BioGRID	16169070
DARS	DKFZp781B11202 \| MGC111579	aspartyl-tRNA synthetase	-	HPRD,BioGRID	7806521
DLEU1	BCMS \| DLB1 \| DLEU2 \| LEU1 \| LEU2 \| MGC22430 \| NCRNA00021 \| XTP6	deleted in lymphocytic leukemia 1 (non-protein coding)	两个杂交	BioGRID	16169070
DYNLL1	DLC1 \|DLC8 \|DNCL1 \|DNClc1 \|LC8 \|LC8A \|MGC126137 \|MGC126138 \|PIN \|HDLC1	dynein, light chain, LC8-type 1	两个杂交	BioGRID	16169070
EIF3F	EIF3S5 \| eIF3-p47	eukaryotic translation initiation factor 3, subunit F	两个杂交	BioGRID	16169070
EXOSC4	FLJ20591 \| RRP41 \| RRP41A \| Rrp41p \| SKI6 \| Ski6p \| hRrp41p \| p12A	外泌体组件4	-	HPRD,BioGRID	15231747
FAS	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	Fas (TNF receptor superfamily, member 6)	两个杂交	BioGRID	16169070
HBXIP	MGC71071 \| XIP	hepatitis B virus x interacting protein	两个杂交	BioGRID	16169070
HSPE1	CPN10 \| GROES \| HSP10	heat shock 10kDa protein 1 (chaperonin 10)	两个杂交	BioGRID	16169070
ITSN1	ITSN \| MGC134948 \| MGC134949 \| SH3D1A \| SH3P17	intersectin 1 (SH3 domain protein)	两个杂交	BioGRID	16169070
KIF1B	CMT2 \| CMT2A \| CMT2A1 \| FLJ23699 \| HMSNII \| KIAA0591 \| KIAA1448 \| KLP \| MGC134844	kinesin family member 1B	两个杂交	BioGRID	16169070
喇嘛4	DKFZp686D23145 \| LAMA3 \| LAMA4*-1	层粘连蛋白，α4	两个杂交	BioGRID	16169070
LSM3	SMX4 \| USS2 \| YLR438C	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	两个杂交	BioGRID	16169070
MAD2L1BP	CMT2 \| KIAA0110 \| MGC11282 \| RP1-261G23.6	MAD2L1 binding protein	两个杂交	BioGRID	16169070
MAP3K7	tak1 \|TGF1A	mitogen-activated protein kinase kinase kinase 7	-	HPRD	14743216
MLLT3	AF9 \| FLJ2035 \| YEATS3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	两个杂交	BioGRID	16169070
MNAT1	MAT1 \| RNF66 \| TFB3	menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)	两个杂交	BioGRID	16169070
MRPL42	HSPC204 \| MRP-L31 \| MRPL31 \| MRPS32 \| PTD007 \| RPML31	mitochondrial ribosomal protein L42	两个杂交	BioGRID	16169070
NEU1	FLJ93471 \|nanh \|neu \|sial1	sialidase 1 (lysosomal sialidase)	两个杂交	BioGRID	16169070
ORMDL3	-	ORM1-like 3 (S. cerevisiae)	两个杂交	BioGRID	16169070
PAEP	GD \| GdA \| GdF \| GdS \| MGC138509 \| MGC142288 \| PAEG \| PEP \| PP14	progestagen-associated endometrial protein	两个杂交	BioGRID	16169070
PAFAH1B3	-	platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa	两个杂交	BioGRID	16169070
PAPSS1	ATPSK1 \| PAPSS \| SK1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	两个杂交	BioGRID	16169070
PCDHA4	CNR1 \| CNRN1 \| CRNR1 \| MGC138307 \| MGC142169 \| PCDH-ALPHA4	protocadherin alpha 4	两个杂交	BioGRID	16169070
PFN2	D3S1319E \| PFL	profilin 2	两个杂交	BioGRID	16169070
PHYHIP	DYRK1AP3 \| KIAA0273 \| PAHX-AP \| PAHXAP1	phytanoyl-CoA 2-hydroxylase interacting protein	两个杂交	BioGRID	16169070
plaur	CD87 \| UPAR \| URKR	plasminogen activator, urokinase receptor	两个杂交	BioGRID	16169070
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	-	HPRD,BioGRID	11886851
POL2	DPE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	两个杂交	BioGRID	16169070
POLR2C	RPB3 \|RPB31 \|HRPB33 \|HSRPB3	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	两个杂交	BioGRID	16169070
PQBP1	MRX55 \| MRXS3 \| MRXS8 \| NPW38 \| RENS1 \| SHS	polyglutamine binding protein 1	两个杂交	BioGRID	16169070
PSG9	PSG11 \| PSGII	特异性β-1-糖蛋白9	两个杂交	BioGRID	16169070
PSMD11	MGC3844 \| Rpn6 \| S9 \| p44.5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	两个杂交	BioGRID	16169070
PTPN4	PTPMEG \| PTPMEG1	蛋白质酪氨酸磷酸酶,non-receptor类型4(megakaryocyte)	两个杂交	BioGRID	16169070
PTPRCAP	CD45-AP \| LPAP \| MGC138602 \| MGC138603	protein tyrosine phosphatase, receptor type, C-associated protein	两个杂交	BioGRID	16169070
RAB27A	GS2 \| HsT18676 \| MGC117246 \| RAB27 \| RAM	RAB27A, member RAS oncogene family	两个杂交	BioGRID	16169070
RFC5	MGC1155 \| RFC36	replication factor C (activator 1) 5, 36.5kDa	两个杂交	BioGRID	16169070
RNF10	KIAA0262 \| MGC126758 \| MGC126764 \| RIE2	ring finger protein 10	两个杂交	BioGRID	16169070
RPA2	REPA2 \| RPA32	replication protein A2, 32kDa	两个杂交	BioGRID	16169070
RPLP1	FLJ27448 \| MGC5215 \| P1 \| RPP1	ribosomal protein, large, P1	两个杂交	BioGRID	16169070
RSRC1	BM-011 \|MGC12197	arginine/serine-rich coiled-coil 1	两个杂交	BioGRID	16169070
SARS2	FLJ20450 \| SARS \| SARSM \| SERS \| SYS \| SerRSmt \| mtSerRS	seryl-tRNA synthetase 2, mitochondrial	-	HPRD	15109557
SERPINB9	CAP-3 \| CAP3 \| PI9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	两个杂交	BioGRID	16169070
SSR1	DKFZp781N23103 \| FLJ14232 \| FLJ22100 \| FLJ23034 \| FLJ78242 \| FLJ93042 \| TRAPA	signal sequence receptor, alpha	两个杂交	BioGRID	16169070
STMN2	SCG10 \| SCGN10 \| SGC10	stathmin-like 2	两个杂交	BioGRID	16169070
SULT1E1	EST \| EST-1 \| MGC34459 \| STE	sulfotransferase family 1E, estrogen-preferring, member 1	两个杂交	BioGRID	16169070
TAF9	AD-004 \|AK6 \|CGI-137 \|电影院\|cip \|MGC1603 \|MGC3647 \|MGC5067 \|MGC：1603 \|MGC：3647 \| MGC:5067 \| TAF2G \| TAFII31 \| TAFII32 \| TAFIID32	TAF9RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa	两个杂交	BioGRID	16169070
TGIF1	HPE4 \| MGC39747 \| MGC5066 \| TGIF	TGFB诱导的因子同源物ox 1	两个杂交	BioGRID	16169070
TMPRSS3	DFNB10 \| DFNB8 \| ECHOS1 \| TADG12	transmembrane protease, serine 3	两个杂交	BioGRID	16169070
TP53BP2	53BP2 \| ASPP2 \| BBP \| PPP1R13A \| p53BP2	tumor protein p53 binding protein, 2	两个杂交	BioGRID	16169070
TPT1	FLJ27337 \| HRF \| TCTP \| p02	tumor protein, translationally-controlled 1	-	HPRD	14623968
TRADD	Hs.89862 \| MGC11078	TNFRSF1A-associated via death domain	-	HPRD	14743216
trdmt1	DNMT2 \|M.Hsaiip \|Pumet \|RNMT1	tRNA aspartic acid methyltransferase 1	两个杂交	BioGRID	16169070
TTR	HsT2651 \| PALB \| TBPA	transthyretin	两个杂交	BioGRID	16169070
UBQLN4	A1U \| C1orf6 \| CIP75 \| UBIN	泛素4	两个杂交	BioGRID	16169070
VARS	G7A \| VARS1 \| VARS2	valyl-tRNA synthetase	-	HPRD,BioGRID	2556394\|3169261
WARS	GAMMA-2 \| IFI53 \| IFP53	tryptophanyl-tRNA synthetase	WRS interacts with EF-1-alpha.	BIND	11829477
XPO5	FLJ14239 \| FLJ32057 \| FLJ45606 \| KIAA1291	exportin 5	-	HPRD,BioGRID	12426393
XRN2	-	5'-3' exoribonuclease 2	-	HPRD,BioGRID	15231747
ZCCHC10	FLJ20094	zinc finger, CCHC domain containing 10	两个杂交	BioGRID	16169070
ZNF24	KOX17 \| RSG-A \| ZNF191 \| ZSCAN3 \| Zfp191	zinc finger protein 24	两个杂交	BioGRID	16169070
ZNF259	MGC110983 \| ZPR1	zinc finger protein 259	-	HPRD,BioGRID	9852145

V.途径注释

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME TRANSLATION	222	75	该途径中的所有SZGR 2.0基因
REACTOME PEPTIDE CHAIN ELONGATION	153	41	该途径中的所有SZGR 2.0基因
REACTOME METABOLISM OF PROTEINS	518	242	该途径中的所有SZGR 2.0基因
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	该途径中的所有SZGR 2.0基因
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP	108	67	该途径中的所有SZGR 2.0基因
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN	116	79	该途径中的所有SZGR 2.0基因
BASAKI YBX1 TARGETS DN	384	230	该途径中的所有SZGR 2.0基因
TIEN INTESTINE PROBIOTICS 2HR UP	27	19	该途径中的所有SZGR 2.0基因
TIEN INTESTINE PROBIOTICS 6HR UP	55	34	该途径中的所有SZGR 2.0基因
TIEN INTESTINE PROBIOTICS 24HR DN	214	133	该途径中的所有SZGR 2.0基因
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 DN	67	43	该途径中的所有SZGR 2.0基因
VANHARANTA UTERINE FIBROID WITH 7Q DELETION DN	36	23	该途径中的所有SZGR 2.0基因
JOHANSSON GLIOMAGENESIS BY PDGFB UP	58	44	该途径中的所有SZGR 2.0基因
MATTIOLI MGUS VS PCL	116	62	该途径中的所有SZGR 2.0基因
DIRMEIER LMP1 RESPONSE EARLY	66	48	该途径中的所有SZGR 2.0基因
MOHANKUMAR TLX1 TARGETS UP	414	287	该途径中的所有SZGR 2.0基因
Jazag TGFB1信号传导DN	35	24	该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK	1652	1023	该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK	1442	892	该途径中的所有SZGR 2.0基因
ALCALA APOPTOSIS	88	60	该途径中的所有SZGR 2.0基因
Colin Pilocytic星形胶质细胞瘤与胶质母细胞瘤UP	35	32	该途径中的所有SZGR 2.0基因
NADLER OBESITY DN	48	34	该途径中的所有SZGR 2.0基因
THEILGAARD NEUTROPHIL AT SKIN WOUND UP	77	52	该途径中的所有SZGR 2.0基因
Nguyen Notch1靶向DN	86	67	该途径中的所有SZGR 2.0基因
MA MYELOID DIFFERENTIATION UP	39	29	该途径中的所有SZGR 2.0基因
MUNSHI MULTIPLE MYELOMA UP	81	52	该途径中的所有SZGR 2.0基因
LEE CALORIE RESTRICTION NEOCORTEX UP	83	66	该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 10HR DN	56	37	该途径中的所有SZGR 2.0基因
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	该途径中的所有SZGR 2.0基因
JIANG AGING HYPOTHALAMUS DN	40	31	该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE UP	1691年	1088	该途径中的所有SZGR 2.0基因
MODY HIPPOCAMPUS PRENATAL	42	33	该途径中的所有SZGR 2.0基因
Lee Calorie限制新皮层DN	88	58	该途径中的所有SZGR 2.0基因
JIANG HYPOXIA NORMAL	311	205	该途径中的所有SZGR 2.0基因
ZAMORA NOS2 TARGETS DN	96	71	该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	该途径中的所有SZGR 2.0基因
KIM LRRC3B TARGETS	30	24	该途径中的所有SZGR 2.0基因
LEIN LOCALIZED TO PROXIMAL DENDRITES	37	26	该途径中的所有SZGR 2.0基因
EHLERS ANEUPLOIDY UP	41	29	该途径中的所有SZGR 2.0基因
WEST ADRENOCORTICAL TUMOR DN	546	362	该途径中的所有SZGR 2.0基因
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN	102	65	该途径中的所有SZGR 2.0基因
HSIAO HOUSEKEEPING GENES	389	245	该途径中的所有SZGR 2.0基因
iritani mad1靶向DN	47	30	该途径中的所有SZGR 2.0基因
JISON SICKLE CELL DISEASE DN	181	97	该途径中的所有SZGR 2.0基因
YAGI AML WITH INV 16 TRANSLOCATION	422	277	该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 30MIN DN	150	99	该途径中的所有SZGR 2.0基因
MARTENS TRETINOIN RESPONSE DN	841	431	该途径中的所有SZGR 2.0基因
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	该途径中的所有SZGR 2.0基因
Wierenga PML Interactome	42	23	该途径中的所有SZGR 2.0基因
JOHNSTONE PARVB TARGETS 2 UP	140	94	该途径中的所有SZGR 2.0基因
BILANGES SERUM AND RAPAMYCIN SENSITIVE GENES	68	35	该途径中的所有SZGR 2.0基因
BILANGES SERUM RESPONSE TRANSLATION	37	20	该途径中的所有SZGR 2.0基因
ALFANO MYC TARGETS	239	156	该途径中的所有SZGR 2.0基因
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF	516	308	该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family	Target position			mirna id	miRNA seq
miRNA family	UTR start	UTR end	Match method	mirna id	miRNA seq
miR-33	116	122	m8	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	116	122	m8	HSA-MIR-33B	GUGCAUUGCUGUUGCAUUGCA
mir-382	235	241	m8	hsa-miR-382^brain	GAAGUUGUUCGUGGUGGAUUCG
mir-542-3p	253	259	1A	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-543	148	154	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click这里查看与SZ相关的miRNA列表。
大脑:microrna的表达大脑基于on miRNA microarray expression studies. Click这里to see the list of brain related miRNAs.

Gene Page:EEF1A1