Gene Page:EEF1B2

Summary?
GeneID 1933
Symbol EEF1B2
Synonyms EEF1B|EEF1B1|EF1B
Description eukaryotic translation elongation factor 1 beta 2
Reference MIM:600655|HGNC:HGNC:3208|Ensembl:ENSG00000114942|HPRD:02804|Vega:OTTHUMG00000132891
Gene type protein-coding
Map location 2q33.3
Pascal p-value 0.014
Sherlock p-value 0.369
Fetal beta 1.716
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01016
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00916
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0113

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06707338 2 207024452 EEF1B2 2.42E-9 -0.012 1.81E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16841037 chr1 4316543 EEF1B2 1933 0.04 trans
rs11120206 chr1 206610593 EEF1B2 1933 0.19 trans
rs2716736 chr2 39947946 EEF1B2 1933 0.04 trans
rs6759186 chr2 230376822 EEF1B2 1933 0.08 trans
rs2713946 chr4 111197804 EEF1B2 1933 0.06 trans
rs467856 chr5 3128168 EEF1B2 1933 0.14 trans
rs13175086 chr5 174691428 EEF1B2 1933 0 trans
rs2016128 chr6 42442743 EEF1B2 1933 0.17 trans
rs12255258 chr10 106306927 EEF1B2 1933 0.18 trans
rs2397390 chr10 132403765 EEF1B2 1933 0.15 trans
rs4275531 chr10 132403792 EEF1B2 1933 0.15 trans
rs17570016 chr11 51428309 EEF1B2 1933 0.18 trans
rs998923 chr13 35507810 EEF1B2 1933 0.12 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26页ostconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DSCAM 0.81 0.78
WASF1 0.81 0.79
LMO7 0.80 0.81
SSBP3 0.80 0.85
TANC2 0.79 0.78
KCNK9 0.78 0.81
GPD1L 0.78 0.79
AC135352.1 0.78 0.78
PRDM2 0.78 0.83
SLC35F1 0.78 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SERPINB6 -0.66 -0.71
C11orf67 -0.61 -0.69
HSD17B14 -0.60 -0.67
DBI -0.60 -0.74
AF347015.31 -0.59 -0.65
RHOC -0.59 -0.70
MT-CO2 -0.59 -0.66
ACSF2 -0.58 -0.68
AF347015.21 -0.58 -0.70
BDH2 -0.58 -0.64

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003746 translation elongation factor activity NAS 1886777
GO:0005515 protein binding 新闻学会 16169070|17353931
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006414 translational elongation EXP 15189156
GO:0006414 translational elongation NAS 1886777
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 10368288
GO:0005853 eukaryotic translation elongation factor 1 complex NAS 1886777

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME TRANSLATION 222 75 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518 242 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 142 96 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162 104 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147 101 All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146 104 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER CHEMOTHERAPY DN 41 28 All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC DN 59 35 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP 151 100 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP 69 41 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS INTERMEDIATE PROGENITOR 149 84 All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425 261 All SZGR 2.0 genes in this pathway
CHNG MULTIPLE MYELOMA HYPERPLOID UP 52 25 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 89 56 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 181 97 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
BILANGES SERUM AND RAPAMYCIN SENSITIVE GENES 68 35 All SZGR 2.0 genes in this pathway
BILANGES SERUM RESPONSE TRANSLATION 37 20 All SZGR 2.0 genes in this pathway
HOLLEMAN ASPARAGINASE RESISTANCE B ALL UP 26 15 All SZGR 2.0 genes in this pathway