Gene Page:EEF1D

Summary?
GeneID 1936
Symbol EEF1D
Synonyms EF-1D|EF1D|FP1047
Description eukaryotic translation elongation factor 1 delta
Reference MIM:130592|HGNC:HGNC:3211|Ensembl:ENSG00000104529|HPRD:00560|Vega:OTTHUMG00000165191
Gene type protein-coding
Map location 8q24.3
Pascal p-value 0.016
Sherlock p-value 0.079
Fetal beta 0.894
DMG 1 (# studies)
eGene Myers' cis & trans
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
简历:PGCnp Genome-wide Association Study GWAS
DMG:Montano_2016 Genome-wide DNA methylation analysis This dataset includes 172 replicated associations between CpGs with schizophrenia. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg17636309 8 144672242 EEF1D 2.06E-4 0.007 0.158 DMG:Montano_2016
cg04249066 8 144680433 EEF1D;TIGD5 4.109E-4 -0.314 0.044 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs924274 chr1 61479290 EEF1D 1936 0.11 trans
rs4436485 chr10 103245360 EEF1D 1936 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PCDHGC4 0.90 0.89
SARM1 0.89 0.95
MAGED1 0.89 0.92
TBCD 0.89 0.92
FGD1 0.88 0.94
PACS1 0.88 0.94
DTX1 0.88 0.92
PIK3R2 0.88 0.94
SMPD3 0.88 0.94
WDR40C 0.88 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.75 -0.86
AF347015.31 -0.75 -0.84
AF347015.33 -0.74 -0.83
AF347015.27 -0.74 -0.84
AF347015.8 -0.72 -0.85
MT-CYB -0.72 -0.83
S100B -0.71 -0.78
AF347015.15 -0.70 -0.82
AF347015.2 -0.70 -0.84
FXYD1 -0.70 -0.78

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ASCC2 ASC1p100 activating signal cointegrator 1 complex subunit 2 Two-hybrid BioGRID 16169070
C10orf4 F26C11.1-like | FRA10A | FRA10AC1 chromosome 10 open reading frame 4 Two-hybrid BioGRID 16169070
CD48 BCM1 | BLAST | BLAST1 | MEM-102 | SLAMF2 | hCD48 | mCD48 CD48 molecule Two-hybrid BioGRID 16169070
CDC2 CDC28A | CDK1 | DKFZp686L20222 | MGC111195 cell division cycle 2, G1 to S and G2 to M - HPRD 8051108
CRMP1 DPYSL1 | DRP-1 | DRP1 collapsin response mediator protein 1 Two-hybrid BioGRID 16169070
CSNK2A1 CK2A1 | CKII casein kinase 2, alpha 1 polypeptide - HPRD,BioGRID 10094407
DARS DKFZp781B11202 | MGC111579 aspartyl-tRNA synthetase DRS interacts with unspecified isoform of EF-1-delta. BIND 11829477
EEF1A2 EEF1AL | EF-1-alpha-2 | EF1A | FLJ41696 | HS1 | STN | STNL eukaryotic translation elongation factor 1 alpha 2 Affinity Capture-MS BioGRID 17353931
EEF1D EF-1D | EF1D | FLJ20897 | FP1047 eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) - HPRD 10094407
EEF1D EF-1D | EF1D | FLJ20897 | FP1047 eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) Two-hybrid BioGRID 16169070
EEF1G EF1G | GIG35 eukaryotic translation elongation factor 1 gamma Two-hybrid BioGRID 16169070|16189514
ELF3 EPR-1 | ERT | ESE-1 | ESX E74-like factor 3 (ets domain transcription factor, epithelial-specific ) Affinity Capture-MS BioGRID 17353931
FARSA CML33 | FARSL | FARSLA | FRSA | PheHA phenylalanyl-tRNA合成酶,α亚基 FRS-alpha interacts with an unspecified isoform of EF-1-delta. BIND 11829477
GARS CMT2D | DSMAV | GlyRS | HMN5 | SMAD1 glycyl-tRNA synthetase GRS interacts with an unspecified isoform of EF-1-delta. BIND 11829477
GARS CMT2D | DSMAV | GlyRS | HMN5 | SMAD1 glycyl-tRNA synthetase - HPRD,BioGRID 11829477
HEXDC FLJ23825 hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing Two-hybrid BioGRID 16169070
KTN1 CG1 | KIAA0004 | KNT | MGC133337 | MU-RMS-40.19 kinectin 1 (kinesin receptor) - HPRD,BioGRID 12773547
RIPK3 RIP3 receptor-interacting serine-threonine kinase 3 - HPRD 14743216
TPT1 FLJ27337 | HRF | TCTP | p02 tumor protein, translationally-controlled 1 - HPRD 14623968|15062873
VARS G7A | VARS1 | VARS2 valyl-tRNA synthetase - HPRD 2556394|3169261
VARS G7A | VARS1 | VARS2 valyl-tRNA synthetase - HPRD,BioGRID 2556394|3169261 | 3169261


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME TRANSLATION 222 75 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518 242 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267 178 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN 182 111 All SZGR 2.0 genes in this pathway
CASORELLI APL SECONDARY VS DE NOVO DN 9 5 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 126 86 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 DN 77 46 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242 165 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281 186 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162 116 All SZGR 2.0 genes in this pathway
CHOW RASSF1 TARGETS DN 29 19 All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185 115 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162 104 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147 101 All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146 104 All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178 108 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS 114 71 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236 139 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
妮可KY BREAST CANCER 8Q23 Q24 AMPLICON 157 87 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 87 57 All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION UP 86 55 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO CANTHARIDIN DN 69 46 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 88 58 All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2 118 65 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER BRCA1 UP 36 18 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298 174 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 89 56 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
LI DCP2 BOUND MRNA 89 57 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP 146 75 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL UP 105 46 All SZGR 2.0 genes in this pathway