Gene Page:EEF2
概括?
| 基因 | 1938 |
| Symbol | EEF2 |
| Synonyms | EEF-2|EF-2|EF2|SCA26 |
| Description | eukaryotic translation elongation factor 2 |
| Reference | MIM:130610|HGNC:HGNC:3214|Ensembl:ENSG00000167658|HPRD:00561|Vega:OTTHUMG00000181790 |
| Gene type | protein-coding |
| Map location | 19p13.3 |
| Pascal p-value | 0.844 |
| Sherlock p-value | 0.959 |
| Fetal beta | 1.275 |
| DMG | 2 (# studies) |
| Support | RNA AND PROTEIN SYNTHESIS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL COMPOSITESET Darnell FMRP targets |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
| DMG:vanEijk_2014 | Genome-wide DNA methylation analysis | This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). | 2 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.5959 |
第一节遗传学和表观遗传学注释
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg09968765 | 19 | 3985171 | EEF2 | 7.71E-9 | -0.01 | 3.76E-6 | DMG:Jaffe_2016 |
| cg20366831 | 19 | 3760955 | EEF2 | 8.66E-5 | -3.472 | DMG:vanEijk_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZMIZ1 | 0.97 | 0.96 |
| RAD54L2 | 0.96 | 0.94 |
| CREBBP | 0.96 | 0.96 |
| SETD1B | 0.96 | 0.96 |
| CRAMP1L | 0.96 | 0.96 |
| KIAA1549 | 0.96 | 0.97 |
| IGF1R | 0.96 | 0.94 |
| BCL9 | 0.96 | 0.97 |
| KDM6B | 0.95 | 0.92 |
| XKR7 | 0.95 | 0.96 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SERPINB6 | -0.66 | -0.77 |
| C5orf53 | -0.66 | -0.79 |
| AIFM3 | -0.64 | -0.77 |
| S100B | -0.64 | -0.87 |
| AF347015.31 | -0.64 | -0.92 |
| HEPN1 | -0.64 | -0.75 |
| HLA-F | -0.64 | -0.75 |
| AF347015.27 | -0.63 | -0.89 |
| TSC22D4 | -0.63 | -0.79 |
| ALDOC | -0.63 | -0.70 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| 去：0003746 | translation elongation factor activity | IEA | - | |
| GO:0003924 | GTPase活性 | IEA | - | |
| GO:0005515 | protein binding | 新闻学会 | 17220478 | |
| GO:0005525 | GTP binding | IEA | - | |
| 生物过程 | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0006414 | translational elongation | 经验 | 15189156 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | 细胞质 | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA EIF PATHWAY | 16 | 9 | 该途径中的所有SZGR 2.0基因 |
| PID MTOR 4PATHWAY | 69 | 55 | 该途径中的所有SZGR 2.0基因 |
| REACTOME TRANSLATION | 222 | 75 | 该途径中的所有SZGR 2.0基因 |
| REACTOME PEPTIDE CHAIN ELONGATION | 153 | 41 | 该途径中的所有SZGR 2.0基因 |
| REACTOME METABOLISM OF PROTEINS | 518 | 242 | 该途径中的所有SZGR 2.0基因 |
| PARENT MTOR SIGNALING UP | 567 | 375 | 该途径中的所有SZGR 2.0基因 |
| TIEN INTESTINE PROBIOTICS 24HR DN | 214 | 133 | 该途径中的所有SZGR 2.0基因 |
| PEREZ TP53 TARGETS | 1174 | 695 | 该途径中的所有SZGR 2.0基因 |
| DIRMEIER LMP1 RESPONSE EARLY | 66 | 48 | 该途径中的所有SZGR 2.0基因 |
| GRUETZMANN PANCREATIC CANCER DN | 203 | 134 | 该途径中的所有SZGR 2.0基因 |
| TOMLINS PROSTATE CANCER UP | 40 | 27 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 该途径中的所有SZGR 2.0基因 |
| LOPEZ MBD TARGETS | 957 | 597 | 该途径中的所有SZGR 2.0基因 |
| Benporath Nanog目标 | 988 | 594 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH SOX2 TARGETS | 734 | 436 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH EED TARGETS | 1062 | 725 | 该途径中的所有SZGR 2.0基因 |
| KUROKAWA LIVER CANCER CHEMOTHERAPY DN | 41 | 28 | 该途径中的所有SZGR 2.0基因 |
| ZHOU TNF SIGNALING 4HR | 54 | 36 | 该途径中的所有SZGR 2.0基因 |
| HU GENOTOXIC DAMAGE 24HR | 35 | 22 | 该途径中的所有SZGR 2.0基因 |
| SIMBULAN PARP1 TARGETS UP | 31 | 23 | 该途径中的所有SZGR 2.0基因 |
| GERHOLD ADIPOGENESIS DN | 64 | 44 | 该途径中的所有SZGR 2.0基因 |
| LEE AGING NEOCORTEX UP | 89 | 59 | 该途径中的所有SZGR 2.0基因 |
| ZHOU TNF SIGNALING 30MIN | 54 | 36 | 该途径中的所有SZGR 2.0基因 |
| Lee Calorie限制新皮层DN | 88 | 58 | 该途径中的所有SZGR 2.0基因 |
| ZAMORA NOS2 TARGETS DN | 96 | 71 | 该途径中的所有SZGR 2.0基因 |
| JIANG AGING CEREBRAL CORTEX DN | 54 | 43 | 该途径中的所有SZGR 2.0基因 |
| ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM | 66 | 47 | 该途径中的所有SZGR 2.0基因 |
| ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST | 132 | 93 | 该途径中的所有SZGR 2.0基因 |
| HILLION HMGA1 TARGETS | 90 | 71 | 该途径中的所有SZGR 2.0基因 |
| LEIN OLIGODENDROCYTE MARKERS | 74 | 53 | 该途径中的所有SZGR 2.0基因 |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | 该途径中的所有SZGR 2.0基因 |
| SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN | 154 | 101 | 该途径中的所有SZGR 2.0基因 |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN | 354 | 216 | 该途径中的所有SZGR 2.0基因 |
| ACEVEDO LIVER CANCER DN | 540 | 340 | 该途径中的所有SZGR 2.0基因 |
| GRADE COLON CANCER UP | 871 | 505 | 该途径中的所有SZGR 2.0基因 |
| BHATI G2M ARREST BY 2METHOXYESTRADIOL DN | 127 | 75 | 该途径中的所有SZGR 2.0基因 |
| CHNG MULTIPLE MYELOMA HYPERPLOID UP | 52 | 25 | 该途径中的所有SZGR 2.0基因 |
| MALONEY RESPONSE TO 17AAG UP | 41 | 26 | 该途径中的所有SZGR 2.0基因 |
| BLUM RESPONSE TO SALIRASIB UP | 245 | 159 | 该途径中的所有SZGR 2.0基因 |
| JIANG TIP30 TARGETS UP | 46 | 28 | 该途径中的所有SZGR 2.0基因 |
| FLOTHO PEDIATRIC ALL THERAPY RESPONSE UP | 53 | 33 | 该途径中的所有SZGR 2.0基因 |
| Yoshimura mapk8靶向 | 1305 | 895 | 该途径中的所有SZGR 2.0基因 |
| SWEET LUNG CANCER KRAS UP | 491 | 316 | 该途径中的所有SZGR 2.0基因 |
| SWEET KRAS ONCOGENIC SIGNATURE | 89 | 56 | 该途径中的所有SZGR 2.0基因 |
| 霍夫曼（Hoffmann | 75 | 61 | 该途径中的所有SZGR 2.0基因 |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN | 72 | 47 | 该途径中的所有SZGR 2.0基因 |
| HSIAO HOUSEKEEPING GENES | 389 | 245 | 该途径中的所有SZGR 2.0基因 |
| iritani mad1靶向DN | 47 | 30 | 该途径中的所有SZGR 2.0基因 |
| JISON SICKLE CELL DISEASE DN | 181 | 97 | 该途径中的所有SZGR 2.0基因 |
| WONG EMBRYONIC STEM CELL CORE | 335 | 193 | 该途径中的所有SZGR 2.0基因 |
| 金所有障碍少突细胞麻木ER CORR UP | 756 | 494 | 该途径中的所有SZGR 2.0基因 |
| KIM ALL DISORDERS CALB1 CORR UP | 548 | 370 | 该途径中的所有SZGR 2.0基因 |
| BILANGES SERUM AND RAPAMYCIN SENSITIVE GENES | 68 | 35 | 该途径中的所有SZGR 2.0基因 |
| PURBEY TARGETS OF CTBP1 AND SATB1 UP | 87 | 52 | 该途径中的所有SZGR 2.0基因 |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | 该途径中的所有SZGR 2.0基因 |