Gene Page:EFNB1

Summary?
GeneID 1947
Symbol EFNB1
Synonyms CFND | CFNS | EFB1 | EFL3 | EPLG2 | Elk-L | LERK2
Description ephrin-B1
Reference MIM:300035|HGNC:HGNC:3226|Ensembl:ENSG00000090776|HPRD:02072|Vega:OTTHUMG00000021751
Gene type protein-coding
Map location Xq12
Fetal beta 0.993

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:PGC128 Genome-wide Association Study A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp Genome-wide Association Study GWAS
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0172

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs5937157 chrX 68377126 TG 5.742E-11 intergenic EFNB1,PJA1 dist=315120;dist=3455


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GRIN2A 0.91 0.86
DLGAP2 0.90 0.82
MEF2D 0.89 0.74
DIRAS2 0.89 0.77
TMEM132D 0.88 0.82
KCNB1 0.88 0.76
IQSEC2 0.88 0.82
TRHDE 0.88 0.86
MFSD4 0.87 0.88
PITPNM3 0.87 0.86
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BCL7C -0.46 -0.57
HEBP2 -0.46 -0.66
GTF3C6 -0.43 -0.45
RPL23A -0.43 -0.52
FADS2 -0.43 -0.39
C9orf46 -0.42 -0.48
C21orf57 -0.42 -0.49
TRAF4 -0.41 -0.50
RPS12 -0.41 -0.56
DYNLT1 -0.40 -0.56

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 9883737
GO:0005515 protein binding ISS -
GO:0046875 ephrin receptor binding TAS 8798744
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007411 axon guidance IEA axon (GO term level: 13) -
GO:0007399 nervous system development IEA neurite (GO term level: 5) -
GO:0001755 neural crest cell migration IEA -
GO:0007155 cell adhesion TAS 8798744
GO:0007267 cell-cell signaling TAS 8798744
GO:0009880 embryonic pattern specification IEA -
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
GO:0042102 positive regulation of T cell proliferation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0045202 synapse ISS neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0005625 soluble fraction TAS 8798744
GO:0016020 membrane IEA -
GO:0005887 integral to plasma membrane TAS 8660976
GO:0045121 膜筏 IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
EPHA3 ETK | ETK1 | HEK | HEK4 | TYRO4 EPH receptor A3 Reconstituted Complex BioGRID 9195962
EPHB1 ELK | EPHT2 | FLJ37986 | Hek6 | NET EPH receptor B1 The membrane bound ligand ELK-L interacts with the receptor ELK. This interaction was modeled on a demonstrated interaction between ELK-L from human and ELK from rat. BIND 7973638|8755474
EPHB1 ELK | EPHT2 | FLJ37986 | Hek6 | NET EPH receptor B1 - HPRD,BioGRID 10669731|12223469
EPHB2 CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5 EPH receptor B2 - HPRD 8878483
EPHB2 CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5 EPH receptor B2 The membrane bound ligand ELK-L interacts with the receptor NUK. This interaction was modeled on a demonstrated interaction between ELK-L from human and NUK from mouse. BIND 8755474
GRIP2 - glutamate receptor interacting protein 2 in vitro
in vivo
Two-hybrid		 BioGRID 9883737|10197531
NCK2 GRB4 | NCKbeta NCK adaptor protein 2 - HPRD 11557983
PICK1 MGC15204 | PICK | PRKCABP protein interacting with PRKCA 1 - HPRD,BioGRID 9883737
PTPN13 DKFZp686J1497 | FAP-1 | PNP1 | PTP-BAS | PTP-BL | PTP1E | PTPL1 | PTPLE protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) - HPRD,BioGRID 9920925
RGS3 C2PA | FLJ20370 | FLJ31516 | FLJ90496 | PDZ-RGS3 | RGP3 regulator of G-protein signaling 3 - HPRD,BioGRID 11301003
SDCBP MDA-9 | ST1 | SYCL | TACIP18 syndecan binding protein (syntenin) - HPRD,BioGRID 9920925
SORBS1 CAP | DKFZp451C066 | DKFZp586P1422 | FLAF2 | FLJ12406 | KIAA1296 | R85FL | SH3D5 | SH3P12 | SORB1 sorbin and SH3 domain containing 1 - HPRD 11557983
SRC ASV | SRC1 | c-SRC | p60-Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) - HPRD,BioGRID 8878483


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 40 38 All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY 30 25 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION DN 100 64 All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL UP 83 51 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN 36 24 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL FGF3 8 7 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
GENTILE UV LOW DOSE UP 27 19 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 53 34 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN 135 88 All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS DN 25 21 All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261 166 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN WS 33 22 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP 56 41 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE DN 50 33 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 All SZGR 2.0 genes in this pathway
TERAO AOX4 TARGETS SKIN UP 38 27 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-103/107 834 840 1A hsa-miR-103brain AGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-124/506 200 206 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-129-5p 730 736 1A hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-140 1496 1502 1A hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-15/16/195/424/497 1178 1184 1A hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-150 1303 1309 1A hsa-miR-150 UCUCCCAACCCUUGUACCAGUG
miR-17-5p/20/93.mr/106/519.d 1148 1154 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-185 936 942 m8 hsa-miR-185brain UGGAGAGAAAGGCAGUUC
miR-208 799 805 1A hsa-miR-208 AUAAGACGAGCAAAAAGCUUGU
miR-34/449 1189 1195 1A hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-381 1425 1431 1A hsa - mir - 381 UAUACAAGGGCAAGCUCUCUGU
miR-491 63 69 1A hsa-miR-491brain AGUGGGGAACCCUUCCAUGAGGA
miR-496 1412 1418 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-499 799 805 1A hsa-miR-499 UUAAGACUUGCAGUGAUGUUUAA
miR-503 1178 1184 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG