Gene Page:EFNB3

Summary?
GeneID 1949
Symbol EFNB3
Synonyms EFL6|EPLG8|LERK8
Description ephrin-B3
Reference MIM:602297|HGNC:HGNC:3228|Ensembl:ENSG00000108947|HPRD:03804|Vega:OTTHUMG00000108161
Gene type protein-coding
Map location 17p13.1
Pascal p-value 0.09
Sherlock p-value 0.489
eGene Cerebellum
元
Support Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AK3 0.73 0.67
ACBD5 0.72 0.68
ERLIN2 0.72 0.74
KDSR 0.71 0.68
PIK3C2A 0.69 0.70
ARHGAP5 0.69 0.70
GALC 0.69 0.69
ITGAV 0.69 0.70
RNF141 0.68 0.66
MCCC2 0.68 0.66
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
IL32 -0.51 -0.46
AF347015.21 -0.44 -0.30
CLEC3B -0.44 -0.42
FAM159B -0.41 -0.26
AL050337.1 -0.41 -0.26
APOC1 -0.40 -0.29
AL353354.3 -0.38 -0.13
GNG11 -0.38 -0.25
AL022328.1 -0.38 -0.34
C16orf74 -0.38 -0.30

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005005 transmembrane-ephrin receptor activity TAS 9126477
GO:0046875 ephrin receptor binding IDA 8808709
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0016198 axon choice point recognition IEA neuron, axon (GO term level: 14) -
GO:0007399 nervous system development TAS neurite (GO term level: 5) 9126477
GO:0007267 cell-cell signaling TAS 9126477
GO:0007628 adult walking behavior IEA -
GO:0048013 ephrin receptor signaling pathway IDA 8808709
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
GO:0044419 interspecies interaction between organisms IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0016020 membrane IEA -
GO:0005887 integral to plasma membrane TAS 9126477

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 40 38 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241 146 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260 143 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 2 UP 30 24 All SZGR 2.0 genes in this pathway
MANTOVANI NFKB TARGETS DN 11 6 All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING DN 49 37 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL FGF3 8 7 All SZGR 2.0 genes in this pathway
GEISS RESPONSE TO DSRNA DN 16 8 All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA UP 52 33 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS DN 29 16 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV 63 44 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226 164 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN 75 61 All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN 72 47 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN 74 47 All SZGR 2.0 genes in this pathway
金所有障碍OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP 140 81 All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS 77 62 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124/506 921 927 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-138 1574 1580 m8 hsa-miR-138brain AGCUGGUGUUGUGAAUC
miR-145 913 920 1A,m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-192/215 1605 1611 1A hsa-miR-192 CUGACCUAUGAAUUGACAGCC
hsa-miR-215 AUGACCUAUGAAUUGACAGAC
miR-204/211 1737 1744 1A,m8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-28 1639 1645 m8 hsa-miR-28brain AAGGAGCUCACAGUCUAUUGAG
miR-34/449 1199 1205 1A hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC