Gene Page:CELSR3

概括?
基因 1951
Symbol CELSR3
Synonyms adgrc3 | cdhf11 | egfl1 | fmi1 | hfmi1 | megf2 | resda1
Description cadherin EGF LAG seven-pass G-type receptor 3
Reference MIM:604264|HGNC:HGNC:3230|Ensembl:ENSG00000008300|HPRD:09179|Vega:OTTHUMG00000133544
Gene type protein-coding
Map location 3p21.31
Pascal p-value 0.006
Sherlock p-value 0.299
TADA p-value 0.036
Fetal beta 1.641
eGene Myers' cis & trans
Support CompositeSet
Darnell FMRP targets
Ascano FMRP targets

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type 筛 CG46 Trait Study
CELSR3 chr3 48694701 C T NM_001407 p.1277V>M missense Schizophrenia DNM:Fromer_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16955618 chr15 29937543 CELSR3 1951 0 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
UBE2K 0.84 0.87
Rab14 0.83 0.88
SLC25A36 0.82 0.88
FBXO28 0.82 0.89
GOPC 0.81 0.87
HINT3 0.81 0.86
G3BP2 0.81 0.87
OTUD6B 0.81 0.86
NAT13 0.81 0.86
UCHL5 0.81 0.85
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FXYD1 -0.62 -0.69
MT-CO2 -0.60 -0.67
HSD17B14 -0.60 -0.66
AF347015.26 -0.58 -0.64
TLCD1 -0.58 -0.66
CST3 -0.58 -0.67
AF347015.31 -0.58 -0.66
AF347015.8 -0.58 -0.66
EIF4EBP3 -0.57 -0.65
SLC25A18 -0.57 -0.63

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IEA -
GO:0004930 G-protein coupled receptor activity IEA -
GO:0005509 calcium ion binding IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0007218 neuropeptide signaling pathway IEA Neurotransmitter (GO term level: 8) -
GO:0007156 homophilic cell adhesion IEA -
GO:0007165 signal transduction IEA -
GO:0007275 multicellular organismal development IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO：0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
SLEBOS HEAD AND NECK CANCER WITH HPV UP 84 43 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 该途径中的所有SZGR 2.0基因
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 该途径中的所有SZGR 2.0基因
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER 140 73 该途径中的所有SZGR 2.0基因
JAZAG TGFB1 SIGNALING VIA SMAD4 UP 108 66 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER LUMINAL B UP 172 109 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 142 103 该途径中的所有SZGR 2.0基因
JISON SICKLE CELL DISEASE DN 181 97 该途径中的所有SZGR 2.0基因
WONG ADULT TISSUE STEM MODULE 721 492 该途径中的所有SZGR 2.0基因
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210 148 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE LATE 1137 655 该途径中的所有SZGR 2.0基因
PLASARI TGFB1 SIGNALING VIA NFIC 10HR UP 54 38 该途径中的所有SZGR 2.0基因
DELACROIX RAR BOUND ES 462 273 该途径中的所有SZGR 2.0基因
ALFANO MYC TARGETS 239 156 该途径中的所有SZGR 2.0基因
FOSTER KDM1A TARGETS DN 211 119 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 747 753 m8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-124.1 635 641 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 635 641 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-181 916 922 1A hsa-miR-181abrain aacauucaacgcugucggugagu
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-183 814 820 m8 hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-204/211 1019 1026 1A,m8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-30-5p 689 696 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-326 236 242 1A hsa-miR-326 CCUCUGGGCCCUUCCUCCAG
miR-34b 633 639 m8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-409-5p 232 238 1A hsa-miR-409-5p AGGUUACCCGAGCAACUUUGCA
miR-486 944 950 1A hsa-miR-486 UCCUGUACUGAGCUGCCCCGAG
mir-495 1106 1112 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-500 181 187 m8 hsa-miR-500 AUGCACCUGGGCAAGGAUUCUG