Gene Page:CELSR2

Summary?
GeneID 1952
Symbol CELSR2
Synonyms ADGRC2|CDHF10|EGFL2|Flamingo1|MEGF3
Description cadherin EGF LAG seven-pass G-type receptor 2
Reference MIM:604265|HGNC:HGNC:3231|Ensembl:ENSG00000143126|HPRD:05040|Vega:OTTHUMG00000012003
Gene type protein-coding
Map location 1p21
Pascal p-value 0.346
Sherlock p-value 0.25
TADA p-value 0.034
Fetal beta -0.239
eGene Meta
Support CompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Gulsuner_2013 Whole Exome Sequencing analysis 155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
CELSR2 chr1 109793969 C G NM_001408 p.423A>G missense Schizophrenia DNM:Gulsuner_2013
CELSR2 chr1 109793295 C G NM_001408 . silent Schizophrenia DNM:Gulsuner_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
COPS2 0.92 0.89
C11orf58 0.91 0.91
YWHAE 0.91 0.88
TAF7 0.91 0.89
TIPRL 0.90 0.90
CUL2 0.90 0.90
PTGES3 0.90 0.89
CNOT7 0.90 0.90
PSMD14 0.90 0.88
SMNDC1 0.90 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.69 -0.71
AF347015.8 -0.68 -0.72
AF347015.2 -0.68 -0.73
AF347015.31 -0.67 -0.71
AF347015.15 -0.67 -0.72
MT-CYB -0.67 -0.70
AF347015.33 -0.66 -0.69
AF347015.27 -0.66 -0.70
AF347015.26 -0.66 -0.70
AF347015.21 -0.62 -0.63

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IEA -
GO:0004930 G-protein coupled receptor activity IEA -
GO:0004930 G-protein coupled receptor activity NAS 10907856
GO:0005509 calcium ion binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007218 neuropeptide signaling pathway IEA Neurotransmitter (GO term level: 8) -
GO:0048813 dendrite morphogenesis ISS 神经突,dendrite (GO term level: 12) -
GO:0007156 homophilic cell adhesion IEA -
GO:0016055 Wnt receptor signaling pathway ISS -
GO:0007165 signal transduction IEA -
GO:0007275 multicellular organismal development IEA -
GO:0022407 regulation of cell-cell adhesion ISS -
GO:0021999 neural plate anterioposterior pattern formation ISS -
GO:0032583 regulation of gene-specific transcription ISS -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm ISS -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane NAS 10907856
GO:0005886 plasma membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE DN 84 53 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
DEURIG T细胞PROLYMPHOCYTIC白血病 368 234 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
CHOW RASSF1 TARGETS DN 29 19 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT UP 21 15 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 140 85 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C6 39 27 All SZGR 2.0 genes in this pathway
KAAB心脏心房和心室 249 170 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180 125 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE UP 66 44 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN 41 26 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING DN 45 31 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 109 63 All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A UP 104 57 All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK UP 10 7 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 134 83 All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS 85 55 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229 149 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway
GUILLAUMOND KLF10 TARGETS UP 51 39 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-103/107 663 670 1A,m8 hsa-miR-103brain AGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-125/351 311 317 1A hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain UCCCUGAGACCCUUUAACCUGUG
miR-17-5p/20/93.mr/106/519.d 216 222 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-193 831 837 m8 hsa-miR-193a AACUGGCCUACAAAGUCCCAG
hsa-miR-193b AACUGGCCCUCAAAGUCCCGCUUU
miR-214 1010 1016 m8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-328 232 238 1A hsa-miR-328brain CUGGCCCUCUCUGCCCUUCCGU
miR-431 245 251 1A hsa-miR-431 UGUCUUGCAGGCCGUCAUGCA
miR-485-5p 393 399 m8 hsa-miR-485-5p AGAGGCUGGCCGUGAUGAAUUC
miR-9 361 367 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
miR-96 184 190 m8 hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC