Gene Page:EGR3

Summary？
基因 1960
象征 EGR3
Synonyms EGR-3 |飞行员
Description 早期增长反应3
Reference MIM：602419|HGNC:HGNC:3240|Ensembl:ENSG00000179388|HPRD：03881|Vega:OTTHUMG00000097825
基因类型 蛋白质编码
Map location 8p23-p21
Pascal p-value 0.773
胎儿β -4.408
主持人 Myers' cis & trans

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Association A combined odds ratio method (Sun等。2008), association studies 2 Link to SZGene
GSMA_I Genome scan meta-analysis Psr: 0.031
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.03086
gsma_iie Genome scan meta-analysis (European-ancestry samples) Psr: 0.00057
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症 点击显示详细信息
GO_Annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS5944689 Chrx 24860329 EGR3 1960 0.14 反式
RS5973369 Chrx 35392270 EGR3 1960 0.17 反式
RS5973375 Chrx 35489060 EGR3 1960 0.2 反式
rs2171999 Chrx 35498985 EGR3 1960 0.19 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NONO 0.96 0.93
INTS7 0.96 0.95
XRN2 0.96 0.93
EIF2S3 0.96 0.95
RBMX 0.96 0.93
csgalnact2 0.95 0.94
USP3 0.95 0.82
MCPH1 0.95 0.94
ANP32A 0.95 0.93
CAPRIN1 0.95 0.94
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AIFM3 -0.69 -0.83
HLA-F -0.69 -0.79
C5orf53 -0.68 -0.76
pth1r -0.67 -0.78
FXYD1 -0.67 -0.91
AF347015.31 -0.67 -0.87
IFI27 -0.67 -0.90
TSC22D4 -0.67 -0.82
MT-CO2 -0.66 -0.88
HEPN1 -0.66 -0.77

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0003700 转录factor activity TAS 1906159|9731539
GO:0008270 锌离子结合 IEA -
GO:0046872 metal ion binding IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0007274 神经肌肉突触传播 IEA neuron, Synap (GO term level: 7) -
去：0006355 调节转录，DNA依赖性的调节 IEA -
去：0006350 转录 IEA -
去：0007517 肌肉发育 TAS 9731539
去：0007623 circadian rhythm TAS 9488654
去：0007422 周围神经系统发展 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005622 细胞内 IEA -
去：0005634 nucleus IEA -

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
Biocarta VIP途径 29 26 All SZGR 2.0 genes in this pathway
PC12细胞中的ST分化途径 45 35 All SZGR 2.0 genes in this pathway
pid nfat tfpathway 47 39 All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤 783 507 All SZGR 2.0 genes in this pathway
Huttmann B Cll生存不良DN 60 39 All SZGR 2.0 genes in this pathway
胶原蛋白凝胶中的Oswald造血干细胞 233 161 All SZGR 2.0 genes in this pathway
莱茵所有糖皮质激素治疗DN 362 238 All SZGR 2.0 genes in this pathway
Mullighan MLL签名1 DN 242 165 All SZGR 2.0 genes in this pathway
Mullighan MLL签名2 DN 281 186 All SZGR 2.0 genes in this pathway
runx1 runx1t1融合HSC DN的TONKS目标 187 115 All SZGR 2.0 genes in this pathway
Nagashima NRG1信号向上发出 176 123 All SZGR 2.0 genes in this pathway
Nagashima EGF信号向上 58 40 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
IGF1和IGF2的Pacher靶标 35 27 All SZGR 2.0 genes in this pathway
kokkinakis蛋氨酸剥夺48小时 128 95 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
ENK UV响应表皮DN 508 354 All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合靶向E 97 60 All SZGR 2.0 genes in this pathway
CHASSOT SKIN WOUND 10 9 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE EARLY 66 48 All SZGR 2.0 genes in this pathway
THEODOROU MAMMARY TUMORIGENESIS 31 24 All SZGR 2.0 genes in this pathway
Schlesinger甲基化的癌症 88 64 All SZGR 2.0 genes in this pathway
Benporath SOX2目标 734 436 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
Benporath MYC带Ebox的目标 230 156 All SZGR 2.0 genes in this pathway
Amit EGF响应40 HELA 42 29 All SZGR 2.0 genes in this pathway
Amit EGF响应40 MCF10A 19 11 All SZGR 2.0 genes in this pathway
阿米特血清反应60 mcf10a 57 42 All SZGR 2.0 genes in this pathway
林被肿瘤微环境沉默 108 73 All SZGR 2.0 genes in this pathway
Frasor对雌二醇的反应 37 28 All SZGR 2.0 genes in this pathway
贝克莫昔芬的抵抗 50 36 All SZGR 2.0 genes in this pathway
黑川肝癌化学疗法DN 41 28 All SZGR 2.0 genes in this pathway
FAELT B CLL与VH重新排列 48 34 All SZGR 2.0 genes in this pathway
皮肤上的theilgaard中性粒细胞 77 52 All SZGR 2.0 genes in this pathway
康（Kang）由tert dn永生 102 67 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
伊万诺娃造血干细胞长期 302 191 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228 146 All SZGR 2.0 genes in this pathway
ABE VEGFA目标 20 15 All SZGR 2.0 genes in this pathway
ABE VEGFA目标30MIN 29 21 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
Massarweh对雌二醇的反应 61 47 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
西肾上腺皮质肿瘤DN 546 362 All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS DN 68 48 All SZGR 2.0 genes in this pathway
SEKI炎症反应LPS 77 56 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
LEE SP4 THYMOCYTE 14 11 All SZGR 2.0 genes in this pathway
Meissner Brain HCP带有H3K4ME3和H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN 42 29 All SZGR 2.0 genes in this pathway
Yagi AML带有Inv 16易位 422 277 All SZGR 2.0 genes in this pathway
Uzonyi对白三烯和凝血酶的反应 37 26 All SZGR 2.0 genes in this pathway
由MYC约束 1103 714 All SZGR 2.0 genes in this pathway
Dorn腺病毒感染12小时 29 18 All SZGR 2.0 genes in this pathway
DORN腺病毒感染24小时DN 43 32 All SZGR 2.0 genes in this pathway
DORN腺病毒感染32小时DN 39 28 All SZGR 2.0 genes in this pathway
DORN腺病毒感染48小时DN 40 29 All SZGR 2.0 genes in this pathway
钱德兰转移DN 306 191 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN UP 56 38 All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307 182 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
突变的TP53的Stambolsky靶标 49 35 All SZGR 2.0 genes in this pathway
Kim所有疾病少突胶质细胞编号corr up 756 494 All SZGR 2.0 genes in this pathway
Kim所有疾病Calb1 Corr Up 548 370 All SZGR 2.0 genes in this pathway
Chicas RB1靶向衰老 572 352 All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 145 83 All SZGR 2.0 genes in this pathway
Dutertre雌二醇反应6小时 229 149 All SZGR 2.0 genes in this pathway
Servitja Islet HNF1A靶向 163 111 All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移1 46 33 All SZGR 2.0 genes in this pathway
Plasari TGFB1靶向1小时 34 26 All SZGR 2.0 genes in this pathway
Wang MLL目标 289 188 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway
Smirnov对IR 6小时DN的响应 114 69 All SZGR 2.0 genes in this pathway
ZWANG CLASS 2 TRANSIENTLY INDUCED BY EGF 51 29 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
let-7/98 1594年 1601 1A，M8 hsa-let-7abrain ugagguaguaguauauaguu
hsa-let-7bbrain ugagguaguagguuguguguguu
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain ugagguaggagguuauauagu
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain ugagguaguugugugugugcugu
miR-142-5p 1827 1833 M8 HSA-MIR-142-5P cauaaaguagaaagcacuac
miR-146 2250 2256 1A hsa-miR-146a UGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrain ugagaacugaauuccauaggcu
miR-17-5p/20/93.mr/106/519.d 1826 1832 1A hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D caaagugccucccuuuagugugu
miR-181 1724 1731 1A，M8 HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-182 2291 2298 1A，M8 HSA-MIR-182 uuuggcaaugguagaacucaca
miR-200bc/429 2077 2083 M8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-203.1 2590 2597 1A，M8 hsa-miR-203 ugaaauguuuaggaccacuag
mir-216 1359 1366 1A，M8 hsa-miR-216 uaaucucagcuggcaacugug
mir-219 2741 2748 1A，M8 hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-23 2376 2382 1A HSA-MIR-23Abrain AUCACAUUGCCAGGGAUUUCC
HSA-MIR-23Bbrain AUCACAUUGCCAGGGAUUACC
HSA-MIR-23Abrain AUCACAUUGCCAGGGAUUUCC
HSA-MIR-23Bbrain AUCACAUUGCCAGGGAUUACC
mir-30-5p 1800 1806 1A HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
mir-323 2101 2108 1A，M8 hsa-miR-323brain gcacauuacggucgaccucu
mir-331 289 295 M8 hsa-miR-331brain GCCCCUGGGCCUAUCCUAGAA
mir-335 581 587 1A hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
mir-380-5p 1014 1020 1A hsa-miR-380-5p UGGUUGACCAUAGAACAUGCGC
hsa-miR-563 AGGUUGACAUACGUUUCCC
miR-381 2448 2454 1A HSA-MIR-381 uauacaagggcaagcucucugu
miR-494 712 718 M8 HSA-MIR-494brain ugaaacauacgggaaaccucuu
mir-7 690 697 1A，M8 hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG
mir-9 438 444 M8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
mir-96 2292 2298 1A hsa-miR-96brain uuuggcacuagcacauuuuugc