Gene Page:EPHA2
Summary？
| 基因 | 1969 |
| 象征 | EPHA2 |
| Synonyms | ARCC2|CTPA|CTPP1|CTRCT6|ECK |
| Description | EPH receptor A2 |
| 参考erence | MIM:176946|HGNC:HGNC:3386|ENSEMBL：ENSG00000142627|HPRD：01494|Vega：Otthumg00000009527 |
| 基因类型 | 蛋白质编码 |
| Map location | 136 |
| Pascal p-value | 0.22 |
| TADA p-value | 0.004 |
| 胎儿β | 0.016 |
| 主持人 | Myers' cis & trans |
| Support | CompositeSet |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | 这项研究报道了WES对623个精神分裂症三重奏的研究，该研究使用基因组DNA报告了DNM。 | |
| GO_Annotation | 将与神经相关的关键字映射到基因本体论注释 | 与神经相关的关键字的命中：1 |
Section I. Genetics and epigenetics annotation
DNM表
DNM表| Gene | 染色体 | 位置 | 参考 | alt | 成绩单 | AA change | Mutation type | 筛 | CG46 | 特征 | 学习 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EPHA2 | CHR1 | 16458218..16458219 | CG | C | NM_004431 NM_004431 |
。 。 |
拼接 frameshift |
Schizophrenia | DNM:Fromer_2014 |
eQTL annotation
| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | pvalue | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| RS2746486 | CHR1 | 17465173 | EPHA2 | 1969 | 0.19 | 顺式 |
第二节。转录组注释
一般基因表达（GTEX）
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PSMA7 | 0.93 | 0.95 |
| PSMD13 | 0.91 | 0.92 |
| ruvbl2 | 0.90 | 0.93 |
| CCT7 | 0.90 | 0.90 |
| EIF6 | 0.90 | 0.94 |
| RRP9 | 0.89 | 0.90 |
| DCTPP1 | 0.89 | 0.92 |
| WIBG | 0.89 | 0.90 |
| CFL1 | 0.89 | 0.90 |
| C19orf10 | 0.89 | 0.92 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.8 | -0.75 | -0.76 |
| AF347015.33 | -0.75 | -0.77 |
| AF347015.27 | -0.74 | -0.77 |
| AF347015.15 | -0.74 | -0.77 |
| mt-cyb | -0.74 | -0.76 |
| MT-CO2 | -0.74 | -0.72 |
| AF347015.2 | -0.73 | -0.75 |
| AF347015.26 | -0.73 | -0.78 |
| AF347015.31 | -0.72 | -0.72 |
| AF347015.9 | -0.67 | -0.73 |
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0000166 | nucleotide binding | IEA | - | |
| GO:0004872 | receptor activity | IEA | - | |
| 去：0005003 | ephrin受体活性 | IEA | - | |
| 去：0005524 | ATP binding | IEA | - | |
| GO：0016740 | 转移酶活性 | IEA | - | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO:0030182 | 神经元分化 | IEA | 神经元（GO期限：8） | - |
| 去：0006468 | protein amino acid phosphorylation | IEA | - | |
| GO:0007165 | 信号转导 | TAS | 2174105 | |
| GO：0048013 | ephrin receptor signaling pathway | IEA | - | |
| GO:0007275 | multicellular organismal development | TAS | 7918100 | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0016020 | membrane | IEA | - | |
| GO：0016021 | 膜不可或缺 | IEA | - | |
| 去：0005887 | integral to plasma membrane | TAS | 2174105 |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| ACP1 | haap |MGC111030 |MGC3499 | acid phosphatase 1, soluble | - | HPRD,BioGRID | 12167657 |
| EFNA1 | B61 |ECKLG | EFL1 | EPLG1 | LERK1 | TNFAIP4 | ephrin-a1 | The membrane bound ligand B61 interacts with the receptor ECK. This interaction was modeled on a demonstrated interaction between B61 from human and ECK from mouse. | 绑定 | 7973638|8755474 |
| EFNA1 | B61 |ECKLG | EFL1 | EPLG1 | LERK1 | TNFAIP4 | ephrin-a1 | - | HPRD | 7973638|8755474 |
| EFNA2 | ELF-1 |eplg6 |hek7-l |LERK6 | ephrin-a2 | - | HPRD | 8755474 |
| EFNA3 | efl2 |eplg3 |EHK1-L |lerk3 | ephrin-a3 | 膜结合的配体EHK1-L与受体ECK相互作用。这种相互作用是在人类和来自小鼠ECK的EHK1-L之间的相互作用上建模的。 | 绑定 | 7973638|8755474 |
| EFNA3 | efl2 |eplg3 |EHK1-L |lerk3 | ephrin-a3 | - | HPRD | 12907451 |
| EFNA4 | efl4 |eplg4 |lerk4 |MGC125826 | ephrin-a4 | - | HPRD | 10607706 |
| EFNA4 | efl4 |eplg4 |lerk4 |MGC125826 | ephrin-a4 | - | HPRD | 8755474|10607706 |
| EFNA5 | AF1 |efl5 |eplg7 |Glc1m |lerk7 |破布 | ephrin-a5 | - | HPRD | 9245480 |
| GRB2 | 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 | 生长因子受体结合蛋白2 | - | HPRD,BioGRID | 12400011 |
| PIK3R1 | GRB1 | p85 | p85-ALPHA | 磷酸肌醇3-激酶，调节亚基1（alpha） | 亲和力捕获 - 韦斯特恩 重构的复合物 Two-hybrid |
Biogrid | 7982920 |
| PTK2 | FADK | FAK | FAK1 | pp125FAK | PTK2 protein tyrosine kinase 2 | - | HPRD,BioGRID | 10655584 |
| PTPN11 | bptp3 |CFC |MGC14433 |NS1 |PTP-1D |PTP2C |SH-PTP2 |sh-ptp3 |SHP2 | protein tyrosine phosphatase, non-receptor type 11 | 亲和力捕获 - 韦斯特恩 | Biogrid | 10655584 |
| SHC1 | FLJ26504 | SHC | SHCA | SHC（SRC同源性2结构域）转化蛋白1 | - | HPRD,BioGRID | 12400011 |
| SLA | Sla1 |拍击 | 类似于SRC的适应器 | - | HPRD,BioGRID | 7543898 |
| TNFAIP1 | B12 |B61 |EDP1 |MGC2317 | 肿瘤坏死因子，α诱导的蛋白1（内皮） | - | HPRD | 7536959 |
Section V. Pathway annotation
第六节。microRNA注释
| mirna家族 | Target position | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| miR-124/506 | 472 | 478 | M8 | hsa-miR-506 | UAAGGCACCCUUCUGAGUAGA |
| HSA-MIR-124brain | UAAGGCACGCGGUGAAUGCC | ||||
| miR-141/200a | 754 | 761 | 1A，M8 | HSA-MIR-141 | uaacacugucugugugugugaugg |
| hsa-miR-200a | UAACACUGUCUGGUAACGAUGU | ||||
| mir-224 | 833 | 839 | 1A | hsa-miR-224 | CAAGUCACUAGUGGUUCCGUUUA |
| miR-26 | 36 | 43 | 1A，M8 | HSA-MIR-26Abrain | UUCAAGUAAUCCAGGAUAGGC |
| HSA-MIR-26BSZ | UUCAAGUAAUUCAGGAUAGGUU | ||||
| miR-93.hd/291-3p/294/295/302/372/373/520 | 223 | 230 | 1A，M8 | hsa-miR-93brain | aaagugcuguucgugcagguag |
| hsa-miR-302a | uaagugcuugcauguuuguga | ||||
| hsa-miR-302b | UAAGUGCUUCCAUGUUUUAGUAG | ||||
| hsa-miR-302c | uaagugcuuccauguucagugg | ||||
| hsa-miR-302d | UAAGUGCUUCCAUGUUUGAGUGU | ||||
| HSA-MIR-372 | AAAGUGCUGCGACAUUUGAGCGU | ||||
| HSA-MIR-373 | Gaagugcuucgauuuggggugu | ||||
| HSA-MIR-520E | Aaagugcuuuuuugaggg | ||||
| hsa-miR-520a | AAAGUGCUUCCCUUUGGACUGU | ||||
| hsa-miR-520b | aaagugcuuuuuuagaggg | ||||
| hsa-miR-520c | AAAGUGCUUCCUUUUAGAGGGUU | ||||
| hsa-miR-520d | aaaguguuugugggguggguu | ||||