Gene Page:AIF1

Summary?
GeneID 199
Symbol AIF1
Synonyms AIF-1|IBA1|IRT-1|IRT1
Description allograft inflammatory factor 1
Reference MIM:601833|HGNC:HGNC:352|Ensembl:ENSG00000204472|HPRD:03496|Vega:OTTHUMG00000031246
Gene type protein-coding
Map location 6p21.3
Pascal p-value 1E-12
Sherlock p-value 0.466
Fetal beta -1.552
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.033
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs13397687 chr2 123655344 AIF1 199 0.03 trans
rs16846456 chr3 172757337 AIF1 199 0.03 trans
rs10116858 chr9 20300988 AIF1 199 0.07 trans
rs10743139 chr11 10425326 AIF1 199 0 trans
rs10160667 chr11 10426577 AIF1 199 0.17 trans
rs11216730 chr11 117918701 AIF1 199 0.13 trans
snp_a-2081410 0 AIF1 199 0.02 trans
rs1002154 chr20 37077619 AIF1 199 0.05 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RBM47 0.70 0.40
F5 0.68 0.41
PRLR 0.68 0.38
CP 0.67 0.43
KCNJ13 0.66 0.30
SLC5A5 0.66 0.29
ABCA4 0.65 0.32
CLIC6 0.65 0.37
SLC13A4 0.63 0.23
FOLR1 0.61 0.27
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RPL35 -0.34 -0.52
RPS7 -0.32 -0.48
RPL27 -0.32 -0.48
FAU -0.32 -0.46
RPS10 -0.32 -0.45
RPL31 -0.31 -0.49
PFDN5 -0.31 -0.47
UXT -0.31 -0.45
ALKBH7 -0.30 -0.44
C22orf32 -0.30 -0.46

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003674 molecular_function ND -
GO:0005509 calcium ion binding IEA -
GO:0005515 protein binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006950 response to stress TAS 9614071
GO:0007050 cell cycle arrest TAS 9614071
GO:0008285 negative regulation of cell proliferation TAS 9614071
GO:0008150 biological_process ND -
GO:0006954 inflammatory response TAS 8912632
GO:0051017 actin filament bundle formation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0001726 ruffle IEA -
GO:0001891 phagocytic cup IEA -
GO:0005575 cellular_component ND -
GO:0005634 nucleus TAS 9614071
GO:0005737 cytoplasm IEA -
GO:0005884 actin filament IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT DN 47 32 All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL DIVIDING DN 12 6 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 87 58 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN 76 57 All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING DN 68 44 All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191 131 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA DN 41 27 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 UP 81 52 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 80 66 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 131 79 All SZGR 2.0 genes in this pathway
WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL UP 58 38 All SZGR 2.0 genes in this pathway
RAY TARGETS OF P210 BCR ABL FUSION DN 16 11 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315 201 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235 144 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
LEE RECENT THYMIC EMIGRANT 227 128 All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200 115 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288 168 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP 76 46 All SZGR 2.0 genes in this pathway
NIELSEN SYNOVIAL SARCOMA DN 20 13 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 116 74 All SZGR 2.0 genes in this pathway
KIM GLIS2 TARGETS UP 84 61 All SZGR 2.0 genes in this pathway