Gene Page:A2M

Summary?
GeneID 2
Symbol A2M
Synonyms A2MD|CPAMD5|FWP007|S863-7
Description alpha-2-macroglobulin
Reference MIM:103950|HGNC:HGNC:7|Ensembl:ENSG00000175899|HPRD:00072|Vega:OTTHUMG00000150267
Gene type protein-coding
Map location 12p13.31
Pascal p-value 0.529
Sherlock p-value 0.668
Fetal beta -1.656
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
设置na基因me Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 4.179

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position 最近的基因 P (dis) Beta (dis) FDR (dis) Study
cg27166707 12 9227209 A2M 7.16E-5 0.404 0.025 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1999514 chr13 84147878 A2M 2 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NDUFB7 0.88 0.47
LSMD1 0.87 0.51
C17orf90 0.85 0.61
ZNF593 0.84 0.58
C7orf59 0.83 0.58
C19orf60 0.83 0.70
HBQ1 0.83 0.62
C9orf16 0.83 0.55
PSMB10 0.82 0.50
NDUFA2 0.82 0.49
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CANX -0.39 -0.37
AC005332.1 -0.38 -0.30
ARHGAP5 -0.38 -0.40
DYNC1LI2 -0.37 -0.30
ZNHIT6 -0.37 -0.34
KIAA1033 -0.37 -0.37
RAB5A -0.37 -0.32
XPOT -0.36 -0.29
CD2AP -0.36 -0.36
YES1 -0.36 -0.43

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004867 serine-type endopeptidase inhibitor activity IEA -
GO:0017114 wide-spectrum protease inhibitor activity IEA -
GO:0019959 interleukin-8 binding 新闻学会 10880251
GO:0019966 interleukin-1 binding IDA 9714181
GO:0019899 enzyme binding 新闻学会 11435418
GO:0043120 tumor necrosis factor binding IDA 9714181
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0051260 protein homooligomerization NAS -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region EXP 59727
GO:0005576 extracellular region NAS 14718574
GO:0005634 nucleus IDA 18029348
GO:0005737 cytoplasm IDA 18029348
GO:0031093 platelet alpha granule lumen EXP 59727

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ADAM19 FKSG34 | MADDAM | MLTNB ADAM metallopeptidase domain 19 (meltrin beta) - HPRD 11162584
ADAMTS1 C3-C5 | KIAA1346 | METH1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 - HPRD,BioGRID 10373500
AMBP EDC1 | HCP | HI30 | IATIL | ITI | ITIL | ITILC | UTI alpha-1-microglobulin/bikunin precursor - HPRD,BioGRID 1697852|7519849
|7533162
APOE AD2 | LPG | MGC1571 | apoprotein apolipoprotein E - HPRD,BioGRID 9831625
B2M - beta-2-microglobulin - HPRD,BioGRID 10731476
CPB2 CPU | PCPB | TAFI carboxypeptidase B2 (plasma) Reconstituted Complex BioGRID 8662763
CTSB APPS | CPSB cathepsin B - HPRD 2476070
ELA1 - elastase 1, pancreatic - HPRD 6153632|6191979
HSPA5 BIP | FLJ26106 | GRP78 | MIF2 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) - HPRD,BioGRID 12194978
IL10 CSIF | IL-10 | IL10A | MGC126450 | MGC126451 | TGIF interleukin 10 - HPRD,BioGRID 10714547
IL1B IL-1 | IL1-BETA | IL1F2 interleukin 1, beta - HPRD 9714181
IL4 BCGF-1 | BCGF1 | BSF1 | IL-4 | MGC79402 interleukin 4 Reconstituted Complex BioGRID 10714547
KLK13 DKFZp586J1923 | KLK-L4 | KLKL4 kallikrein-related peptidase 13 Reconstituted Complex BioGRID 14687906
KLK3 APS | KLK2A1 | PSA | hK3 kallikrein-related peptidase 3 - HPRD 8583572
KLK3 APS | KLK2A1 | PSA | hK3 kallikrein-related peptidase 3 Affinity Capture-Western BioGRID 1702714
LCAT - lecithin-cholesterol acyltransferase - HPRD,BioGRID 11435418
LEP FLJ94114 | OB | OBS leptin - HPRD,BioGRID 9724081
LRP1 A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) - HPRD,BioGRID 10652313
MMP2 CLG4 | CLG4A | MMP-II | MONA | TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Reconstituted Complex BioGRID 9344465
NGF Beta-NGF | HSAN5 | MGC161426 | MGC161428 | NGFB nerve growth factor (beta polypeptide) - HPRD,BioGRID 10681572
PAEP GD | GdA | GdF | GdS | MGC138509 | MGC142288 | PAEG | PEP | PP14 progestagen-associated endometrial protein - HPRD,BioGRID 11023837
PDGFB FLJ12858 | PDGF2 | SIS | SSV | c-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) - HPRD 10681572
STAT3 APRF | FLJ20882 | HIES | MGC16063 signal transducer and activator of transcription 3 (acute-phase response factor) An unspecified isoform of STAT3 binds APRE. BIND 15950906


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG COMPLEMENT AND COAGULATION CASCADES 69 49 All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY 47 40 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 113 81 All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 89 56 All SZGR 2.0 genes in this pathway
REACTOME HDL MEDIATED LIPID TRANSPORT 15 12 All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE 32 22 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY 17 12 All SZGR 2.0 genes in this pathway
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 46 37 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME LIPOPROTEIN METABOLISM 28 24 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205 140 All SZGR 2.0 genes in this pathway
KORKOLA TERATOMA UP 16 11 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 142 90 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS UP 33 20 All SZGR 2.0 genes in this pathway
HU ANGIOGENESIS DN 37 25 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM DN 25 18 All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 2 DN 19 13 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227 137 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX1 UP 15 10 All SZGR 2.0 genes in this pathway
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA DN 28 21 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION 147 80 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 2 114 76 All SZGR 2.0 genes in this pathway
CHESLER BRAIN D6MIT150 QTL CIS 7 6 All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN 87 69 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
COLLER MYC TARGETS DN 9 5 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP 114 84 All SZGR 2.0 genes in this pathway
TAVOR CEBPA TARGETS DN 30 21 All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA UP 26 22 All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN 102 67 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA DN 41 27 All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE DN 64 45 All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT UP 78 48 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 53 34 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222 139 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
ABE VEGFA TARGETS 20 15 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311 205 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202 115 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM 66 47 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP 174 96 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274 165 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS DN 145 93 All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250 168 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A UP 104 57 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264 159 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO RADIATION THERAPY 32 20 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS UP 153 107 All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222 141 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
ISSAEVA MLL2 TARGETS 62 35 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238 125 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway