Gene Page:CTTN
Summary?
基因 | 2017 |
象征 | CTTN |
Synonyms | EMS1 |
Description | cortactin |
Reference | MIM:164765|HGNC:HGNC:3338|Ensembl:ENSG00000085733|HPRD:01268|Vega:OTTHUMG00000134307 |
基因类型 | 蛋白质编码 |
Map location | 11q13 |
Pascal p-value | 0.195 |
Sherlock p-value | 0.823 |
胎儿β | -0.259 |
DMG | 1(# studies) |
主持人 | Myers' cis & trans |
Support | CELL ADHESION AND TRANSSYNAPTIC SIGNALING G2CDB.HUMANNRC G2Cdb.humanPSD G2Cdb.humanPSP Ascano FMRP targets 潜在的突触基因 |
Gene in Data Sources
基因集名称 | Method of gene set | Description | 信息 |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Nishioka_2013 | 全基因组DNA甲基化分析 | 作者研究了来自18例第一期精神分裂症(FESZ)和15个正常对照的18例外周血细胞中DNA的甲基化谱。 | 1 |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0836 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | 染色体 | 位置 | Nearest gene | p(dis) | Beta (dis) | fdr(dis) | 学习 |
---|---|---|---|---|---|---|---|
cg15383392 | 11 | 70244691 | CTTN | -0.022 | 0.55 | DMG:Nishioka_2013 |
eQTL annotation
SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | pvalue | QVALUE | TSS距离 | EQTL类型 |
---|---|---|---|---|---|---|---|---|
rs7120675 | chr11 | 71050680 | CTTN | 2017 | 0.2 | 顺式 |
第二节。转录组注释
一般基因表达(GTEX)
![Not available](http://www.tjghsg.com/bioinfo/SZGR/GeneImg/CTTN_DE_GTEx.png)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达(brainspan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。
No co-expressed genes in brain regions
第三节。基因本体论注释
分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
---|---|---|---|---|
去:0005515 | 蛋白质结合 | IEA | - | |
去:0005515 | 蛋白质结合 | ISS | - | |
Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
GO:0001726 | ruffle | ISS | - | |
去:0005856 | 细胞骨架 | TAS | 9054437 | |
去:0005625 | soluble fraction | TAS | 9054437 | |
去:0005737 | cytoplasm | IEA | - | |
去:0005737 | cytoplasm | ISS | - | |
GO:0030027 | lamellipodium | IEA | - | |
GO:0030027 | lamellipodium | ISS | - | |
GO:0005938 | 细胞皮质 | IEA | - | |
GO:0005938 | 细胞皮质 | ISS | - |
Section IV. Protein-protein interaction annotation
互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
---|---|---|---|---|---|
ACTR2 | ARP2 | ARP2肌动蛋白相关蛋白2同源物(酵母) | Affinity Capture-MS | Biogrid | 11018051 |
ACTR3 | arp3 | ARP3肌动蛋白相关蛋白3同源物(酵母) | - | HPRD,BioGRID | 12176742 |
ARHGAP17 | DKFZp564A1363 | FLJ37567 | FLJ43368 | MGC87805 | MST066 | MST110 | MSTP038 | MSTP066 | MSTP110 | NADRIN | RICH1 | WBP15 | Rho GTPase activating protein 17 | 重构的复合物 | Biogrid | 11431473 |
arhgap8 | BPGAP1 | FLJ20185 | PP610 | Rho GTPase激活蛋白8 | BPGAP1 interacts with Cortactin. | 绑定 | 15064355 |
ARPC2 | ARC34 |PNAS-139 |Pro2446 |p34-arc | actin related protein 2/3 complex, subunit 2, 34kDa | Affinity Capture-MS 亲和力捕获 - 韦斯特恩 |
Biogrid | 11018051 |
ARPC3 | ARC21 |p21-arc | 肌动蛋白相关蛋白2/3复合物,亚基3,21KDA | Affinity Capture-MS | Biogrid | 11018051 |
ARPC4 | Arc20 |MGC13544 |P20-arc | 肌动蛋白相关蛋白2/3复合物,亚基4,20KDA | Affinity Capture-MS | Biogrid | 11018051 |
ASAP1 | AMAP1 | CENTB4 | DDEF1 | KIAA1249 | PAG2 | PAP | ZG14P | 带有SH3结构域的ArfGap,Ankyrin重复和pH结构域1 | DDEF1(AMAP1)与CTTN(Cortactin)的未指定同工型相互作用。 | 绑定 | 15719014 |
CASP3 | CPP32 |CPP32B |SCA-1 | caspase 3, apoptosis-related cysteine peptidase | 生化活动 | Biogrid | 11689006 |
CHD3 | Mi-2a | Mi2-ALPHA | ZFH | chromodomain helicase DNA binding protein 3 | Two-hybrid | Biogrid | 16169070 |
CRB2 | FLJ16786 | FLJ38464 | Crumbs同源2(果蝇) | 亲和力捕获 - 韦斯特恩 | Biogrid | 11439336 |
ctnnd1 | CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120 | catenin (cadherin-associated protein), delta 1 | - | HPRD,BioGRID | 12835311 |
ctnnd2 | GT24 | NPRAP | Catenin(钙粘蛋白相关蛋白),三角洲2(神经plakophilin相关的手臂重复蛋白) | - | HPRD | 12835311 |
DNM1 | DNM | dynamin 1 | - | HPRD | 12419186 |
DNM2 | cmtdi1 |cmtdib |di-cmtb |dyn2 |dynii | dynamin 2 | - | HPRD | 12419186 |
FER | TYK3 | FER(FPS/FES相关)酪氨酸激酶 | - | HPRD,BioGRID | 9722593 |
FGD1 | AAS |fgdy |ZFYVE3 | FYVE,Rhogef和pH结构域包含1个 | - | HPRD | 12913069 |
GRB2 | 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 | 生长因子受体结合蛋白2 | - | HPRD | 11439336 |
KCNA2 | HBK5 |HK4 |Hukiv |KV1.2 |MGC50217 |Mk2 |ngk1 |RBK2 | potassium voltage-gated channel, shaker-related subfamily, member 2 | - | HPRD,BioGRID | 12151401 |
mylk | DKFZP686I10125 |FLJ12216 |KRP |MLCK |MLCK1 |MLCK108 |MLCK210 |MSTP083 |mylk1 |smmlck | 肌球蛋白轻链激酶 | - | HPRD,BioGRID | 12408982 |
PXN | FLJ16691 | paxillin | PXN (Paxillin) interacts with an unspecified isoform of CTTN (cortactin). | 绑定 | 15719014 |
SDC3 | n-syndecan |SDCN |Synd3 | Syndecan 3 | - | HPRD,BioGRID | 9553134 |
SHANK2 | cortbp1 |cttnbp1 |Prosap1 |小腿|SPANK-3 | SH3和多个Ankyrin重复域2 | - | HPRD,BioGRID | 9742101 |
SYK | DKFZp313N1010 | FLJ25043 | FLJ37489 | 脾酪氨酸激酶 | - | HPRD,BioGRID | 8636079 |
TJP1 | DKFZP686M05161 |MGC133289 |zo-1 | 紧密连接蛋白1(Zona occludens 1) | - | HPRD | 9792678 | 11018051 |
WASL | DKFZP779G0847 |MGC48327 |n-wasp |nwasp | Wiskott-Aldrich syndrome-like | - | HPRD,BioGRID | 11830518 |
WIPF1 | MGC111041 | PRPL-2 | WASPIP | WIP | 是/WASL相互作用蛋白家族,成员1 | - | HPRD,BioGRID | 12620186 |
Section V. Pathway annotation
第六节。microRNA注释
mirna家族 | Target position | miRNA ID | mirna seq | ||
---|---|---|---|---|---|
UTR开始 | UTR结束 | 匹配方法 | |||
mir-221/222 | 1348 | 1354 | 1A | hsa-miR-221brain | agcuacauugucugugggggguc |
hsa-miR-222brain | agcuacaucuggcuacugggucuc |