Gene Page:EN1

概括?
基因 2019
象征 EN1
Synonyms -
Description engrailed homeobox 1
Reference MIM:131290|HGNC:HGNC:3342|Ensembl:ENSG00000163064|HPRD:08835|Vega:OTTHUMG00000131401
Gene type protein-coding
Map location 2q14.2
Pascal p-value 0.015
Fetal beta -0.049
DMG 1 (# studies)
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV：GWASDB Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search 系统的search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0004
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00755
文学 High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关关键字的命中：4

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg05270938 2 119616568 EN1 6.07E-8 -0.018 1.53E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance EQTL类型
rs10994209 chr10 61877705 EN1 2019 0.17 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ABCB1 0.87 0.88
TPCN1 0.86 0.89
KANK1 0.86 0.87
ATP1A2 0.86 0.87
SFXN5 0.86 0.84
GPR37L1 0.85 0.83
sema3g 0.85 0.85
NACC2 0.85 0.91
SLC6A12 0.85 0.90
预告片 0.84 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
POLB -0.67 -0.77
MED19 -0.67 -0.72
FRG1 -0.66 -0.79
trnau1ap -0.66 -0.73
OCIAD2 -0.66 -0.73
ING4 -0.65 -0.70
DUSP12 -0.65 -0.68
ALKBH2 -0.65 -0.75
COMMD3 -0.65 -0.76
NR2C2AP -0.64 -0.72

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003700 转录因子活性 IEA -
去：0005249 voltage-gated potassium channel activity IEA -
GO:0043565 sequence-specific DNA binding IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0048666 neuron development IEA neuron (GO term level: 9) -
GO:0030917 midbrain-hindbrain boundary development IEA Brain (GO term level: 10) -
GO:0030902 hindbrain development IEA Brain (GO term level: 8) -
GO:0030901 midbrain development IEA Brain (GO term level: 8) -
GO:0001501 skeletal system development TAS 8684466
去：0006355 regulation of transcription, DNA-dependent IEA -
GO:0009954 proximal/distal pattern formation IEA -
GO:0009953 背/腹图形成 IEA -
GO:0009653 anatomical structure morphogenesis TAS 8094370
GO:0006813 potassium ion transport IEA -
GO:0007275 multicellular organismal development IEA -
GO:0043473 pigmentation IEA -
GO：0035115 embryonic forelimb morphogenesis IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -
GO:0008076 voltage-gated potassium channel complex IEA -

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DOANE BREAST CANCER ESR1 DN 48 28 该途径中的所有SZGR 2.0基因
GAUSSMANN MLL AF4 FUSION TARGETS A UP 191 128 该途径中的所有SZGR 2.0基因
BERENJENO TRANSFORMED BY RHOA DN 394 258 该途径中的所有SZGR 2.0基因
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 该途径中的所有SZGR 2.0基因
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 该途径中的所有SZGR 2.0基因
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH EED TARGETS 1062 725 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
BENPORATH PRC2 TARGETS 652 441 该途径中的所有SZGR 2.0基因
BENPORATH ES CORE NINE CORRELATED 100 68 该途径中的所有SZGR 2.0基因
LEIN MIDBRAIN MARKERS 82 55 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER RELAPSE IN BRAIN UP 39 20 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 该途径中的所有SZGR 2.0基因
乳腺癌萧述三腔的DN 564 326 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER BASAL UP 648 398 该途径中的所有SZGR 2.0基因
IZADPANAH STEM CELL ADIPOSE VS BONE DN 108 68 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 该途径中的所有SZGR 2.0基因
BOUDOUKHA BOUND BY IGF2BP2 111 59 该途径中的所有SZGR 2.0基因
DURAND STROMA S UP 297 194 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

mirna家族 Target position miRNA ID miRNA seq
UTR start UTR end Match method
mir-128 754 760 m8 HSA-MIR-128A UCACAGUGAACCGGUCUCUUUU
HSA-MIR-128B UCACAGUGAACCGGUCUCUUUC
miR-181 478 484 m8 HSA-MIR-181Abrain aacauucaacgcugucggugagu
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-29 200 206 1A hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-338 350 356 1A HSA-MIR-338brain uccagauuuuuguuga
miR-369-3p 394 400 1A hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
mir-374 403 410 1A,m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
mir-491 671 677 1A hsa-miR-491brain AGUGGGGAACCCUUCCAUGAGGA
miR-9 706 712 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA