Gene Page:EPB42
Summary?
| GeneID | 2038 |
| Symbol | EPB42 |
| Synonyms | PA|SPH5 |
| Description | erythrocyte membrane protein band 4.2 |
| Reference | MIM:177070|HGNC:HGNC:3381|Ensembl:ENSG00000166947|HPRD:01517|Vega:OTTHUMG00000130701 |
| Gene type | protein-coding |
| Map location | 15q15-q21 |
| Pascal p-value | 0.01 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0494 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C9orf61 | 0.79 | 0.84 |
| PIPOX | 0.78 | 0.83 |
| BDH2 | 0.78 | 0.85 |
| ANKRD35 | 0.78 | 0.79 |
| HADHB | 0.77 | 0.84 |
| NPL2 | 0.76 | 0.83 |
| A2ML1 | 0.76 | 0.76 |
| ADHFE1 | 0.76 | 0.84 |
| PBXIP1 | 0.75 | 0.84 |
| FAH | 0.75 | 0.85 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NOL4 | -0.54 | -0.65 |
| DPF1 | -0.53 | -0.64 |
| ARL4D | -0.52 | -0.61 |
| MYT1L | -0.52 | -0.64 |
| PRKAR2B | -0.52 | -0.64 |
| GPRIN1 | -0.52 | -0.62 |
| MEF2C | -0.52 | -0.67 |
| PPAPR5 | -0.51 | -0.65 |
| CECR6 | -0.51 | -0.60 |
| PLK2 | -0.51 | -0.63 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity | IEA | - | |
| GO:0005515 | protein binding | 新闻学会 | 12970870 | |
| GO:0005524 | ATP binding | TAS | 8608138 | |
| GO:0005200 | structural constituent of cytoskeleton | TAS | 1350227 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0008360 | regulation of cell shape | IEA | - | |
| GO:0018149 | peptide cross-linking | IEA | - | |
| GO:0043249 | erythrocyte maturation | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005856 | cytoskeleton | TAS | 1350227 | |
| GO:0005737 | cytoplasm | IEA | - | |
| GO:0005886 | plasma membrane | TAS | 1350227 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP | 233 | 161 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| SWEET KRAS TARGETS DN | 66 | 39 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS | 185 | 114 | All SZGR 2.0 genes in this pathway |
| FERNANDEZ BOUND BY MYC | 182 | 116 | All SZGR 2.0 genes in this pathway |
| GUO HEX TARGETS DN | 65 | 36 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS MATURE CELL | 293 | 160 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| XU GH1 EXOGENOUS TARGETS UP | 85 | 50 | All SZGR 2.0 genes in this pathway |
| KONDO PROSTATE CANCER WITH H3K27ME3 | 196 | 93 | All SZGR 2.0 genes in this pathway |
| KYNG WERNER SYNDROM AND NORMAL AGING DN | 225 | 124 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 30MIN DN | 150 | 99 | All SZGR 2.0 genes in this pathway |
| GREGORY SYNTHETIC LETHAL WITH IMATINIB | 145 | 83 | All SZGR 2.0 genes in this pathway |
| CHYLA CBFA2T3 TARGETS DN | 242 | 146 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS UP | 504 | 321 | All SZGR 2.0 genes in this pathway |
| STEINER ERYTHROCYTE MEMBRANE GENES | 15 | 10 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM A | 182 | 108 | All SZGR 2.0 genes in this pathway |
| ROESSLER LIVER CANCER METASTASIS UP | 107 | 72 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |