SZGR2 - Beplay体育中心

Summary？

基因	2048
象征	EPHB2
Synonyms	capb \| drt \| ek5 \| epht3 \| erk \| hek5 \| pcbc \| tyro5
Description	EPH receptor B2
Reference	MIM：600997\|HGNC:HGNC:3393\|HPRD:02997\|
基因类型	蛋白质编码
Map location	1p36.1-p35
Pascal p-value	0.267
Sherlock p-value	0.58
胎儿β	1.523
DMG	1(# studies)
主持人	Caudate basal ganglia
Support	潜在的突触基因

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:GWASdb	Genome-wide Association Studies	精神分裂症的GWASDB记录
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	1
go_annotation	将与神经相关的关键字映射到基因本体论注释	与神经相关关键字的命中：7
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.1976

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
CG18156963	1	23153308	EPHB2	1.95E-5	-0.297	0.016	DMG：Wockner_2014

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene	Pearson's Correlation	斯皮尔曼的相关性
ZNF444	0.83	0.87
PRAF2	0.82	0.83
EPN1	0.81	0.84
FBXW5	0.81	0.84
RNF126	0.81	0.83
ZNF580	0.80	0.84
PIM3	0.80	0.85
AC129492.2	0.80	0.82
C11orf68	0.79	0.82
DAPK3	0.79	0.82

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
AF347015.21	-0.53	-0.43
AF347015.8	-0.49	-0.41
AF347015.31	-0.49	-0.41
MT-CO2	-0.48	-0.39
MT-ATP8	-0.47	-0.45
AF347015.27	-0.46	-0.40
mt-cyb	-0.46	-0.38
AF347015.33	-0.45	-0.38
鼻孔	-0.45	-0.40
AF347015.18	-0.44	-0.38

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
GO:0008046	轴突指导receptor activity	IEA	Axon（GO术语级别：6）	-
去：0005102	receptor binding	IEA	神经递质（GO期限：4）	-
去：0000166	nucleotide binding	IEA		-
去：0005005	跨膜 - 氢受体活性	TAS		8589679
GO:0004872	receptor activity	IEA		-
去：0005524	ATP binding	IEA		-
GO：0016740	转移酶活性	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
去：0007411	轴突指导	IEA	axon (GO term level: 13)	-
GO：0048170	positive regulation of long-term neuronal synaptic plasticity	IEA	neuron, neurogenesis, Synap (GO term level: 11)	-
GO：0048168	调节神经元突触可塑性	IEA	neuron, Synap (GO term level: 9)	-
GO：0050770	regulation of axonogenesis	IEA	神经元，Axon（GO术语级别：13）	-
GO:0007399	nervous system development	TAS	神经突（GO期限：5）	8589679
GO:0007169	跨膜受体蛋白酪氨酸激酶信号传导途径	IEA		-
去：0006468	protein amino acid phosphorylation	TAS		-
去：0009887	organ morphogenesis	IEA		-
去：0007612	learning	IEA		-
GO:0045786	细胞周期的负调控	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0016020	membrane	IEA		-
GO：0016021	膜不可或缺	TAS		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
ABL1	ABL \|JTK7 \|BCR/ABL \|c-abl \|P150 \|V-ABL	C-ABL癌基因1，受体酪氨酸激酶	-	HPRD,BioGRID	11494128
ACP1	haap \|MGC111030 \|MGC3499	acid phosphatase 1, soluble	-	HPRD,BioGRID	9499402
ADAM17	CD156b \| MGC71942 \| TACE \| cSVP	ADAM metallopeptidase domain 17	-	HPRD	12058067
BCL2	Bcl-2	B细胞CLL/淋巴瘤2	生化活动	Biogrid	15225643
CRK	crkii	v-crk sarcoma virus CT10 oncogene homolog (avian)	重构的复合物	Biogrid	10644995
EFNB1	CFND \| CFNS \| EFL3 \| EPLG2 \| Elk-L \| LERK2 \| MGC8782	ephrin-B1	-	HPRD	8878483
EFNB1	CFND \| CFNS \| EFL3 \| EPLG2 \| Elk-L \| LERK2 \| MGC8782	ephrin-B1	The membrane bound ligand ELK-L interacts with the receptor NUK. This interaction was modeled on a demonstrated interaction between ELK-L from human and NUK from mouse.	绑定	8755474
EFNB2	EPLG5 \| HTKL \| Htk-L \| LERK5 \| MGC126226 \| MGC126227 \| MGC126228	ephrin-B2	膜结合的配体HTK-L与受体NUK相互作用。这种相互作用是在人类和NUK的HTK-L之间的相互作用上建模的。	绑定	8755474
EFNB2	EPLG5 \| HTKL \| Htk-L \| LERK5 \| MGC126226 \| MGC126227 \| MGC126228	ephrin-B2	-	HPRD,BioGRID	11780069
EPHB2	CAPB \| DRT \| EPHT3 \| ERK \| Hek5 \| MGC87492 \| PCBC \| Tyro5	EPH receptor B2	-	HPRD,BioGRID	9933164
GRIN1	NMDA1 \| NMDAR1 \| NR1	谷氨酸受体，离子型，N-甲基D-天冬氨酸1	-	HPRD	11754835
ITSN1	它的\|MGC134948 \|MGC134949 \|SH3D1A \|SH3P17	intersectin 1 (SH3 domain protein)	-	HPRD,BioGRID	12389031
mllt4	AF-6 \|AF6 \|Afadin \|FLJ34371 \|RP3-431P23.3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	EphB2 interacts with AF6. This interaction was modelled on a demonstrated interaction between EphB2 from human and mouse AF6.	绑定	9707552
mllt4	AF-6 \|AF6 \|Afadin \|FLJ34371 \|RP3-431P23.3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	-	HPRD,BioGRID	9707552
NCK1	MGC12668 \|NCK \|nckalpha	NCK adaptor protein 1	-	HPRD	9233798
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	Ras P21蛋白激活剂（GTPase激活蛋白）1	-	HPRD,BioGRID	9233798\|10644995
RP6-213H19.1	面具\|MST4	丝氨酸/苏氨酸蛋白激酶Mst4	表型增强	Biogrid	11641781
RYK	D3S3195 \| JTK5 \| JTK5A \| RYK1	RYK receptor-like tyrosine kinase	-	HPRD,BioGRID	11956217
src	ASV \| SRC1 \| c-SRC \| p60-Src	V-SRC肉瘤（Schmidt-Ruppin A-2）病毒癌基因同源物（Avian）	-	HPRD,BioGRID	9632142

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG轴突指导	129	103	All SZGR 2.0 genes in this pathway
ST GA12 PATHWAY	23	16	All SZGR 2.0 genes in this pathway
st g alpha i路径	35	29	All SZGR 2.0 genes in this pathway
ST颗粒细胞存活途径	27	23	All SZGR 2.0 genes in this pathway
ST整合素信号通路	82	62	All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION	45	33	All SZGR 2.0 genes in this pathway
ST B CELL ANTIGEN RECEPTOR	40	32	All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY	65	54	All SZGR 2.0 genes in this pathway
ST MYOCYTE AD PATHWAY	27	25	All SZGR 2.0 genes in this pathway
PID EPHB FWD途径	40	38	All SZGR 2.0 genes in this pathway
PID Syndecan 2途径	33	27	All SZGR 2.0 genes in this pathway
PID Ephrinb Rev Pathway	30	25	All SZGR 2.0 genes in this pathway
Laiho结直肠癌锯齿状DN	86	47	All SZGR 2.0 genes in this pathway
vecchi胃癌早期	430	232	All SZGR 2.0 genes in this pathway
Mullighan NPM1突变签名1 DN	126	86	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN	162	116	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN	260	143	All SZGR 2.0 genes in this pathway
多德鼻咽癌DN	1375	806	All SZGR 2.0 genes in this pathway
Provenzani转移	194	112	All SZGR 2.0 genes in this pathway
PAX3 FOXO1融合DN的Begum目标	45	34	All SZGR 2.0 genes in this pathway
XU HGF TARGETS INDUCED BY AKT1 48HR UP	14	8	All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向	1037	673	All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发48小时DN	428	306	All SZGR 2.0 genes in this pathway
Onder CDH1目标2向上	256	159	All SZGR 2.0 genes in this pathway
通过CTNNB1发出的CDH1信号传导	83	58	All SZGR 2.0 genes in this pathway
甜蜜的克拉斯靶向	84	51	All SZGR 2.0 genes in this pathway
Sansom APC目标	126	84	All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn	1237	837	All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP	56	35	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1	39	26	All SZGR 2.0 genes in this pathway
葡萄病毒感染DN的Debiasi凋亡DN	287	208	All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C4	13	10	All SZGR 2.0 genes in this pathway
Browne HCMV感染24小时	148	96	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS	212	121	All SZGR 2.0 genes in this pathway
Sansom APC目标需要MYC	210	123	All SZGR 2.0 genes in this pathway
Sansom Wnt途径需要MYC	58	43	All SZGR 2.0 genes in this pathway
Zheng胶质母细胞瘤可塑性	250	168	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
HUANG DASATINIB RESISTANCE UP	81	53	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记DN	138	92	All SZGR 2.0 genes in this pathway
MCMURRAY TP53 HRAS COOPERATION RESPONSE DN	67	46	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
Jison Sickle细胞疾病	181	106	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP	176	110	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
Lee BMP2靶向DN	882	538	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN	553	343	All SZGR 2.0 genes in this pathway
PLASARI NFIC TARGETS BASAL DN	18	13	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR UP	33	25	All SZGR 2.0 genes in this pathway
Delacroix Rarg Bound MEF	367	231	All SZGR 2.0 genes in this pathway
ZWANG EGF持续DN	61	36	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-128	1497	1504	1A，M8	hsa-miR-128a	ucacagugaaccggucuuuu
miR-128	1497	1504	1A，M8	hsa-miR-128b	ucacagugaaccggucuuc
miR-150	309	316	1A，M8	HSA-MIR-150	UCUCCCAACCCUUGUACCAGUG
miR-185	353	360	1A，M8	HSA-MIR-185^brain	UGGAGAGAAAGGCAGUUC
mir - 203.1	1012	1018	M8	hsa-miR-203	ugaaauguuuaggaccacuag
mir - 203.1	1012	1018	M8	hsa-miR-203	ugaaauguuuaggaccacuag
mir-224	1071	1077	1a	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-24*	1076	1082	1a	HSA-MIR-189	Gugccuacugagagauaucagu
miR-27	1498	1504	M8	HSA-MIR-27A^brain	uucacaguggcuaaguuccgc
miR-27	1498	1504	M8	HSA-MIR-27B^brain	UUCACAGUGGCUAAGUUCUGC
mir-30-5p	888	895	1A，M8	HSA-MIR-30A-5P	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	uguaaacauccuaccucucagcu
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
mir-448	1103	1109	M8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-495	885	891	M8	HSA-MIR-495^brain	Aaacaaacauggugcacuuuuu
				HSA-MIR-495^brain	Aaacaaacauggugcacuuuuu
				HSA-MIR-495^brain	Aaacaaacauggugcacuuuuu
mir-9	1177	1183	M8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:EPHB2