Gene Page:HIPK1

概括?
GeneID 204851
Symbol HIPK1
同义词 Myak|Nbak2
描述 homeodomain interacting protein kinase 1
参考 MIM:608003|HGNC:HGNC:19006|Ensembl:ENSG00000163349|HPRD:06418|Vega:OTTHUMG00000011983
Gene type protein-coding
Map location 1p13.2
Pascal p-value 0.565
Fetal beta 0.234
DMG 1（＃研究）
Support COMPOSITESET
Darnell FMRP targets

数据源中的基因
Gene set name Method of gene set 描述 Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_I 基因组扫描荟萃分析 Psr: 0.0235

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) beta（dis） FDR (dis) Study
ch.1.2681285F 1 114503218 HIPK1 2.628E-4 -1.216 0.038 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 核苷酸结合 IEA -
GO:0003677 DNA binding IEA -
GO:0005515 protein binding 新闻学会 12529400|12702766
GO:0005524 ATP binding IEA -
GO:0004674 蛋白质丝氨酸/苏氨酸激酶活性 IEA -
GO:0016740 transferase activity IEA -
GO:0016301 kinase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0006350 transcription IEA -
GO:0006468 蛋白氨基酸磷酸化 IEA -
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 核 IEA -
GO:0005737 细胞质 IEA -

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN 136 86 该途径中的所有SZGR 2.0基因
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP 108 67 该途径中的所有SZGR 2.0基因
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 该途径中的所有SZGR 2.0基因
Borczuk恶性间皮瘤 305 185 该途径中的所有SZGR 2.0基因
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 该途径中的所有SZGR 2.0基因
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205 127 该途径中的所有SZGR 2.0基因
KIM WT1 TARGETS 8HR UP 164 122 该途径中的所有SZGR 2.0基因
多德鼻咽癌 1821 933 该途径中的所有SZGR 2.0基因
Schlosser血清反应DN 712 443 该途径中的所有SZGR 2.0基因
MOHANKUMAR TLX1 TARGETS UP 414 287 该途径中的所有SZGR 2.0基因
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229 137 该途径中的所有SZGR 2.0基因
Nuytten Nipp1靶向DN 848 527 该途径中的所有SZGR 2.0基因
pasqualucci淋巴瘤通过GC阶段 283 177 该途径中的所有SZGR 2.0基因
SHEN SMARCA2 TARGETS UP 424 268 该途径中的所有SZGR 2.0基因
BYSTROEM CORRELATED WITH IL5 DN 64 47 该途径中的所有SZGR 2.0基因
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP 151 100 该途径中的所有SZGR 2.0基因
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 该途径中的所有SZGR 2.0基因
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 该途径中的所有SZGR 2.0基因
EWSR1 FLI1融合的Zhang目标 88 68 该途径中的所有SZGR 2.0基因
GERY CEBP目标 126 90 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 14HR UP 156 101 该途径中的所有SZGR 2.0基因
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 该途径中的所有SZGR 2.0基因
Gavin Foxp3目标集群T4 94 69 该途径中的所有SZGR 2.0基因
SANSOM APC MYC TARGETS 217 138 该途径中的所有SZGR 2.0基因
FINETTI BREAST CANCERS KINOME GRAY 15 10 该途径中的所有SZGR 2.0基因
FUJII YBX1 TARGETS DN 202 132 该途径中的所有SZGR 2.0基因
NUTT GBM VS AO GLIOMA UP 46 34 该途径中的所有SZGR 2.0基因
JOHNSTONE PARVB TARGETS 2 DN 336 211 该途径中的所有SZGR 2.0基因
EWSR1 ETS融合的Miyagawa目标 259 159 该途径中的所有SZGR 2.0基因
Bakker FOXO3靶向 61 41 该途径中的所有SZGR 2.0基因
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 该途径中的所有SZGR 2.0基因
FORTSCHEGGER PHF8 TARGETS DN 784 464 该途径中的所有SZGR 2.0基因
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE 151 86 该途径中的所有SZGR 2.0基因
ROESSLER LIVER CANCER METASTASIS DN 53 29 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR start UTR end Match method
miR-101 1488 1494 1A HSA-MIR-101 UACAGUACUGUGAUAACUGAAG
miR-124.1 1671年 1677年 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 1625年 1632年 1A,m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124脑 UAAGGCACGCGGUGAAUGCC
hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124脑 UAAGGCACGCGGUGAAUGCC
mir-136 2517 2523 1A hsa-miR-136 ACUCCAUUUGUUUUGAUGAUGGA
mir-139 1489 1495 m8 hsa-miR-139脑 UCUACAGUGCACGUGUCU
miR-141/200a 1382 1389 1A,m8 hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
HSA-MIR-200A UAACACUGUCUGGUAACGAUGU
miR-142-5p 3783 3790 1A,m8 hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
mir-143 995 1001 m8 hsa-miR-143脑 UGAGAUGAAGCACUGUAGCUCA
mir-144 1488 1494 1A hsa-miR-144 uacaguauagauguauguaguag
mir-146 1858年 1865年 1A,m8 hsa-miR-146a UGAGAACUGAAUUCCAUGGGUU
hsa-miR-146b脑 UGAGAACUGAAUUCCAUAGGCU
mir-185 998 1004 m8 hsa-miR-185脑 Uggagaaaggcaguuc
miR-19 1548年 1555年 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b ugugcaaauccaugcaaaacuga
MiR-200BC/429 4217 4223 m8 HSA-MIR-200B UAAUACUGCCUGGUAAUGAUGAC
HSA-MIR-200C uaauacugccggguaaugaugg
HSA-MIR-429 uaauacuguguguguguguaaaaaccgu
miR-203.1 3497 3503 1A HSA-MIR-203 UGAAAUGUUUAGGACCACUAG
miR-214 3154 3160 1A HSA-MIR-214脑 ACAGCAGGCACAGACAGGCAG
miR-221/222 3833 3840 1A,m8 HSA-MIR-221脑 AGCUACAUUGUCUGCUGGGUUUC
HSA-MIR-222脑 AGCUACAUCUGGCUACUGGGUCUC
miR-26 1347 1353 1A hsa-miR-26a脑 Uucaaguaauccaggauaggc
hsa-miR-26bSZ uucaaguaauucaggauagguu
miR-299-5p 1422 1428 1A HSA-MIR-299-5P UGGUUUACCGUCCCACAUACAU
miR-30-5p 1657年 1663年 1A hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
HSA-MIR-30C脑 uguaaacauccuacucucucucucagc
HSA-MIR-30DSZ uguaaacauccccgacuggaag
HSA-MIR-30BSZ UGUAAACAUCCUACACUCAGCU
HSA-MIR-30E-5P uguaaacauccuugacugga
miR-320 1803 1809 m8 HSA-MIR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-323 3791 3797 m8 HSA-MIR-323脑 GCACAUUACACGGUCGACCUCU
miR-329 1365 1371 1A HSA-MIR-329脑 AACACACCUGGUUAACCUCUUU
HSA-MIR-329脑 AACACACCUGGUUAACCUCUUU
miR-33 4257 4263 m8 hsa-miR-33 GUGCAUUGUAGUUGCAUUG
HSA-MIR-33B Gugcauugcuguugcauugca
miR-330 3879 3886 1A,m8 HSA-MIR-330脑 GCAAAGCACGGCCUGCAGAGA
miR-342 1918 1924 1A HSA-MIR-342脑 UCUCACACAGAAAUCGCACCCGUC
mir-365 1510 1516年 m8 hsa-miR-365 uaaugccccuaaaaaauccuuau
mir-381 4207 4213 m8 hsa - mir - 381 UAUACAAGGGCAAGCUCUCUGU
miR-410 3786 3792 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
mir-493-5p 3850 3856 m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
mir-495 3653 3659 m8 hsa-miR-495脑 AAACAAACAUGGUGCACUUCUUU
hsa-miR-495脑 AAACAAACAUGGUGCACUUCUUU
mir-496 4078 4084 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-500 2508 2514 m8 hsa-miR-500 AUGCACCUGGGCAAGGAUUCUG
miR-505 170 176 m8 hsa-miR-505 GUCAACACUUGCUGGUUUCCUC
miR-543 1314 1320 1A HSA-MIR-543 AAACAUUCGCGGUGCACUUCU
HSA-MIR-543 AAACAUUCGCGGUGCACUUCU
miR-9 2108 2115 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA