Gene Page:ERBB3

Summary?
GeneID 2065
Symbol ERBB3
Synonyms ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3
Description erb-b2 receptor tyrosine kinase 3
Reference MIM:190151|HGNC:HGNC:3431|Ensembl:ENSG00000065361|HPRD:01820|Vega:OTTHUMG00000170140
Gene type protein-coding
Map location 12q13
Pascal p-value 0.374
Sherlock p-value 0.068
Fetal beta -2.664
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 2 Link to SZGene
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 5
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 7.3266

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs973234 chr3 189840350 ERBB3 2065 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA neurite (GO term level: 8) -
GO:0000166 nucleotide binding IEA -
GO:0004888 transmembrane receptor activity ISS 7514177
GO:0005524 ATP binding IEA -
GO:0004713 protein tyrosine kinase activity IGI 7556068
GO:0016740 transferase activity IEA -
GO:0019838 growth factor binding IPI 11389077
GO:0019838 growth factor binding ISS 7514177
GO:0042803 protein homodimerization activity NAS 11389077
GO:0030296 protein tyrosine kinase activator activity IDA 7556068
GO:0046982 protein heterodimerization activity IDA 10572067
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0014037 Schwann cell differentiation IEA neuron, axon, Glial (GO term level: 9) -
GO:0021545 cranial nerve development IEA Brain (GO term level: 7) -
GO:0043524 negative regulation of neuron apoptosis IEA neuron (GO term level: 9) -
GO:0007169 跨膜受体蛋白酪氨酸激酶团体naling pathway IEA -
GO:0007169 跨膜受体蛋白酪氨酸激酶团体naling pathway IGI 7556068
GO:0007162 negative regulation of cell adhesion IDA 7556068
GO:0009968 negative regulation of signal transduction IDA 11389077
GO:0006468 protein amino acid phosphorylation IEA -
GO:0007507 heart development IEA -
GO:0014068 positive regulation of phosphoinositide 3-kinase cascade TAS 17701904
GO:0042060 wound healing NAS 12646923
GO:0051048 negative regulation of secretion IDA 10559227
GO:0042127 regulation of cell proliferation IDA 11389077
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0043235 receptor complex ISS Neurotransmitter (GO term level: 4) 7514177
GO:0005576 extracellular region IEA -
GO:0005615 extracellular space IDA 11389077
GO:0016020 membrane IEA -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 2687875
GO:0016323 basolateral plasma membrane IDA 12646923
GO:0016324 apical plasma membrane IEA -
GO:0016328 lateral plasma membrane IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AGTR2 AT2 | ATGR2 | MRX88 angiotensin II receptor, type 2 - HPRD 10710290
CD82 4F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27 CD82 molecule - HPRD,BioGRID 14576349
CSK MGC117393 c-src tyrosine kinase Affinity Capture-MS BioGRID 16729043
EGF HOMG4 | URG epidermal growth factor (beta-urogastrone) - HPRD,BioGRID 12093292
EGFR ERBB | ERBB1 | HER1 | PIG61 | mENA epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) - HPRD,BioGRID 10527633
EGR1 AT225 | G0S30 | KROX-24 | NGFI-A | TIS8 | ZIF-268 | ZNF225 early growth response 1 Two-hybrid BioGRID 12840049
ERBB2 CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) - HPRD 7538656|10799311
ERBB2 CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) - HPRD 7538656
ERBB3 ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) - HPRD 12154198
GRB2 ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 growth factor receptor-bound protein 2 Affinity Capture-MS BioGRID 16729043
GRB7 - growth factor receptor-bound protein 7 - HPRD,BioGRID 9516479
IL6ST CD130 | CDw130 | GP130 | GP130-RAPS | IL6R-beta interleukin 6 signal transducer (gp130, oncostatin M receptor) - HPRD,BioGRID 11821958
MUC1 CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUM mucin 1, cell surface associated - HPRD,BioGRID 11278868
NRG1 ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | NDF | SMDF neuregulin 1 Reconstituted Complex BioGRID 7592681|9168115
|11555649
NRG1 ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | NDF | SMDF neuregulin 1 NDF-alpha interacts with Her3. An interaction between human NDF-alpha and Her3 from an unknown species was demonstrated by experimental system. BIND 7592681
NRG1 ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | NDF | SMDF neuregulin 1 - HPRD 7592681|11555649
NRG2 Don-1 | HRG2 | NTAK neuregulin 2 - HPRD,BioGRID 9168114|9168115
ODF2L KIAA1229 | MGC111060 | RP5-977L11.1 | dJ977L11.1 outer dense fiber of sperm tails 2-like Two-hybrid BioGRID 16169070
PA2G4 EBP1 | HG4-1 | p38-2G4 proliferation-associated 2G4, 38kDa ErbB-3 interacts with EBP1. BIND 10682683
PA2G4 EBP1 | HG4-1 | p38-2G4 proliferation-associated 2G4, 38kDa - HPRD,BioGRID 10682683|11325528
PIK3R1 GRB1 | p85 | p85-ALPHA phosphoinositide-3-kinase, regulatory subunit 1 (alpha) - HPRD,BioGRID 10383151|11546794
PIK3R2 P85B | p85 | p85-BETA phosphoinositide-3-kinase, regulatory subunit 2 (beta) Affinity Capture-MS BioGRID 16729043
PTGES3 P23 | TEBP | cPGES prostaglandin E synthase 3 (cytosolic) - HPRD 10095121
PTK2 FADK | FAK | FAK1 | pp125FAK PTK2 protein tyrosine kinase 2 - HPRD 11807823
PTK6 BRK | FLJ42088 PTK6 protein tyrosine kinase 6 - HPRD,BioGRID 11114724
RGS4 DKFZp761F1924 | MGC2124 | MGC60244 | RGP4 | SCZD9 regulator of G-protein signaling 4 - HPRD,BioGRID 12840049
RNF41 MGC45228 | NRDP1 | SBBI03 ring finger protein 41 Reconstituted Complex BioGRID 11867753
RPN1 DKFZp686B16177 | OST1 | RBPH1 ribophorin I Two-hybrid BioGRID 12840049
SHC1 FLJ26504 | SHC | SHCA SHC (Src homology 2 domain containing) transforming protein 1 - HPRD 9694850
SHC1 FLJ26504 | SHC | SHCA SHC (Src homology 2 domain containing) transforming protein 1 Affinity Capture-MS BioGRID 16729043
SOS1 GF1 | GGF1 | GINGF | HGF | NS4 son of sevenless homolog 1 (Drosophila) - HPRD 11173924
ZNF207 DKFZp761N202 zinc finger protein 207 Two-hybrid BioGRID 12840049


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
BIOCARTA HER2 PATHWAY 22 17 All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY 44 35 All SZGR 2.0 genes in this pathway
PID ERBB NETWORK PATHWAY 15 13 All SZGR 2.0 genes in this pathway
PID A6B1 A6B4 INTEGRIN PATHWAY 46 35 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 90 67 All SZGR 2.0 genes in this pathway
的差别REACTOME对这些基因ERBB2 ERBB3信号 12 9 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB2 SIGNALING 44 34 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE DN 84 53 All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368 234 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380 215 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450 256 All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED DN 86 47 All SZGR 2.0 genes in this pathway
ROY WOUND BLOOD VESSEL DN 22 14 All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL UP 146 99 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP 137 84 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE DN 230 115 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 128 95 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN 75 50 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP 150 93 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271 175 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK UP 116 68 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS DN 62 44 All SZGR 2.0 genes in this pathway
LUCAS HNF4A TARGETS UP 58 36 All SZGR 2.0 genes in this pathway
BREUHAHN GROWTH FACTOR SIGNALING IN LIVER CANCER 22 19 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 127 92 All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178 108 All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 81 57 All SZGR 2.0 genes in this pathway
TERAMOTO OPN TARGETS CLUSTER 1 13 10 All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS UP 92 64 All SZGR 2.0 genes in this pathway
LIN SILENCED BY TUMOR MICROENVIRONMENT 108 73 All SZGR 2.0 genes in this pathway
JEON SMAD6 TARGETS DN 19 14 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169 111 All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO ESTRADIOL DN 82 52 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS DN 46 26 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA UP 98 64 All SZGR 2.0 genes in this pathway
WHITESIDE CISPLATIN RESISTANCE UP 11 7 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C2 54 39 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0 107 72 All SZGR 2.0 genes in this pathway
KUNINGER IGF1 VS PDGFB TARGETS UP 82 51 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318 220 All SZGR 2.0 genes in this pathway
BILD MYC ONCOGENIC SIGNATURE 206 117 All SZGR 2.0 genes in this pathway
YEGNASUBRAMANIAN PROSTATE CANCER 128 60 All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCERS KINOME BLUE 21 16 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA 51 35 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BRAIN DN 85 58 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS DN 97 53 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175 125 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN 210 128 All SZGR 2.0 genes in this pathway
WU SILENCED BY METHYLATION IN BLADDER CANCER 55 42 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 UP 167 99 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 142 103 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 115 74 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210 148 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 149 85 All SZGR 2.0 genes in this pathway
DELPUECH FOXO3 TARGETS UP 68 49 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428 246 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-143 1130 1137 1A,m8 hsa-miR-143brain UGAGAUGAAGCACUGUAGCUCA
hsa-miR-143brain UGAGAUGAAGCACUGUAGCUCA
miR-148/152 1077 1084 1A,m8 hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-205 287 294 1A,m8 hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-22 36 43 1A,m8 hsa-miR-22brain AAGCUGCCAGUUGAAGAACUGU
miR-378 1135 1141 1A hsa-miR-378 CUCCUGACUCCAGGUCCUGUGU