SZGR2 - Beplay体育中心

Summary？

GeneID	2066
Symbol	嗯BB4
Synonyms	ALS19\|HER4\|p180erbB4
Description	ERB-B2受体酪氨酸激酶4
Reference	MIM：600543\|HGNC: HGNC: 3432\|Ensembl:ENSG00000178568\|HPRD:02767\|Vega:OTTHUMG00000133012
基因类型	蛋白质编码
Map location	2q33.3-q34
胎儿β	-0.176
DMG	1(#研究)
Support	潜在的突触基因

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:GWASdb	Genome-wide Association Studies	精神分裂症的GWASDB记录
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	1
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Association	A combined odds ratio method (Sun等。2008), association studies	2	Link to SZGene
gsma_iie	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01016
GSMA_IIA	Genome scan meta-analysis (All samples)	PSR：0.00916
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypal	点击显示详细信息
GO_Annotation	将与神经相关的关键字映射到基因本体论注释	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：33.331

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
cg04784316	2	212609384	嗯BB4	1.001E-4	-0.84	0.028	DMG：Wockner_2014

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
EIF2C1	0.88	0.87
ankfy1	0.88	0.90
ZFYVE26	0.88	0.89
Sec16a	0.88	0.88
trrap	0.87	0.87
EP400	0.87	0.88
ABL1	0.87	0.85
RNF144A	0.86	0.85
KIAA0355	0.86	0.88
dip2a	0.86	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.59	-0.70
MT-CO2	-0.57	-0.70
C5orf53	-0.57	-0.62
HIGD1B	-0.57	-0.70
IFI27	-0.57	-0.67
FXYD1	-0.56	-0.66
C1orf54	-0.54	-0.75
AF347015.21	-0.54	-0.74
AF347015.27	-0.54	-0.65
myl3	-0.54	-0.67

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
GO:0004714	跨膜受体蛋白酪氨酸激酶活性	助教	神经突（GO期限：8）	8383326
去：0000166	nucleotide binding	IEA		-
GO:0004872	receptor activity	IEA		-
去：0005515	蛋白质结合	IPI		9419975\|10572067\|11867753
去：0005524	ATP binding	IEA		-
GO：0016740	转移酶的活动	IEA		-
GO:0046982	蛋白质异二聚化活性	IDA		10572067
Biological process	去学期	证据	神经关键字	PubMed ID
GO:0007169	跨膜受体蛋白酪氨酸激酶信号传导途径	IEA		-
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0007165	signal transduction	IDA		10572067
GO:0008283	cell proliferation	助教		8383326
GO:0007275	multicellular organismal development	助教		8383326
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0016020	膜	IEA		-
去：0005887	integral to plasma membrane	助教		8383326
GO：0016323	基底外侧质膜	IDA		12646923

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
BTC	-	betacellulin	-	HPRD	11254912
CD44	CDW44 \|CSPG8 \|ECMR-III \|hcell \|在\|lhr \|MC56 \|mdu2 \|mdu3 \|MGC10468 \| MIC4 \| MUTCH-I \| Pgp1	CD44分子（印度血型）	-	HPRD,BioGRID	11825873
CRK	crkii	v-crk sarcoma virus CT10 oncogene homolog (avian)	Affinity Capture-MS	Biogrid	16729043
CTGF	CCN2 \| HCS24 \| IGFBP8 \| MGC102839 \| NOV2	connective tissue growth factor	-	HPRD	12297288
DLG1	DKFZP761P0818 \|DKFZP781B0426 \|dlgh1 \|SAP97 \|DJ1061C18.1.1 \|HDLG	discs, large homolog 1 (Drosophila)	-	HPRD,BioGRID	12175853
DLG2	DKFZP781D1854 \|DKFZP781E0954 \|FLJ37266 \|MGC131811 \|PSD-93	discs, large homolog 2, chapsyn-110 (Drosophila)	-	HPRD,BioGRID	10725395
DLG2	DKFZP781D1854 \|DKFZP781E0954 \|FLJ37266 \|MGC131811 \|PSD-93	discs, large homolog 2, chapsyn-110 (Drosophila)	ERBB-4与Chapsyn-110相互作用。	绑定	10725395
DLG3	KIAA1232 \|MRX \|MRX90 \|NE-DLG \|nedlg \|SAP102	圆盘，大型同源物3（果蝇神经内分泌-DLG，果蝇）	-	HPRD,BioGRID	10725395\|12175853
DLG3	KIAA1232 \|MRX \|MRX90 \|NE-DLG \|nedlg \|SAP102	圆盘，大型同源物3（果蝇神经内分泌-DLG，果蝇）	ERBB-4与SAP-102相互作用。	绑定	10725395
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	圆盘，大型同源物4（果蝇）	-	HPRD,BioGRID	10725395
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	圆盘，大型同源物4（果蝇）	ERBB-4与PSD-95相互作用。	绑定	10725395
嗯BB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	亲和力捕获 - 韦斯特恩	Biogrid	10839362
嗯EG	嗯	epiregulin	-	HPRD,BioGRID	9419975
GRB2	灰烬\|EGFRBP-GRB2 \|Grb3-3 \|MST084 \|MSTP084	growth factor receptor-bound protein 2	Affinity Capture-MS	Biogrid	16729043
HBEGF	DTR \| DTS \| DTSF \| HEGFL	肝素结合EGF样生长因子	-	HPRD	9135143
MUC1	CD227 \|EMA \|H23AG \|mam6 \|Pem \|Pemt \|棕榈	mucin 1, cell surface associated	-	HPRD,BioGRID	11278868
NCK1	MGC12668 \|NCK \|nckalpha	NCK adaptor protein 1	Affinity Capture-MS	Biogrid	16729043
NRG1	ARIA \| GGF \| GGF2 \| HGL \| HRG \| HRG1 \| HRGA \| NDF \| SMDF	neuregulin 1	重构的复合物	Biogrid	9168115
NRG1	ARIA \| GGF \| GGF2 \| HGL \| HRG \| HRG1 \| HRGA \| NDF \| SMDF	neuregulin 1	-	HPRD	7721889\|8062828 \|10537356
NRG2	Don-1 \| HRG2 \| NTAK	neuregulin 2	-	HPRD,BioGRID	9168114\|9168115
NRG3	HRG3 \|Pro-NRG3	neuregulin 3	-	HPRD	9275162
NRG4	DKFZP779N0541 \|DKFZP779N1944 \|HRG4	neuregulin 4	-	HPRD	10348342
PIK3R2	P85B \|P85 \|p85-beta	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	Affinity Capture-MS	Biogrid	16729043
PTPN11	bptp3 \|CFC \|MGC14433 \|NS1 \|PTP-1D \|PTP2C \|SH-PTP2 \|sh-ptp3 \|SHP2	protein tyrosine phosphatase, non-receptor type 11	Affinity Capture-MS	Biogrid	16729043
RNF41	MGC45228 \| NRDP1 \| SBBI03	环手指蛋白41	-	HPRD,BioGRID	11867753
SHC1	FLJ26504 \| SHC \| SHCA	SHC（SRC同源性2结构域）转化蛋白1	Affinity Capture-MS	Biogrid	16729043
SNTB2	D16S2531E \| EST25263 \| SNT2B2 \| SNT3 \| SNTL	Syntrophin，β2（肌营养不良蛋白相关的蛋白A1，59KDA，碱性成分2）	-	HPRD,BioGRID	10725395
SNTB2	D16S2531E \| EST25263 \| SNT2B2 \| SNT3 \| SNTL	Syntrophin，β2（肌营养不良蛋白相关的蛋白A1，59KDA，碱性成分2）	ErbB-4 interacts with beta 2-syntropin.	绑定	10725395
STAT5A	MGF \| STAT5	signal transducer and activator of transcription 5A	Affinity Capture-MS 亲和力捕获 - 韦斯特恩	Biogrid	15534001\|16729043
YAP1	YAP \| YAP2 \| YAP65 \| YKI	是相关的蛋白质1，65KDA	-	HPRD,BioGRID	15023535

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
kegg钙信号通路	178	134	All SZGR 2.0 genes in this pathway
KEGG内吞作用	183	132	All SZGR 2.0 genes in this pathway
BIOCARTA HER2 PATHWAY	22	17	All SZGR 2.0 genes in this pathway
SIG PIP3在心脏肌周期中发出信号	67	54	All SZGR 2.0 genes in this pathway
PID ERBB4 PATHWAY	38	32	All SZGR 2.0 genes in this pathway
PID ERBB网络途径	15	13	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	22	20	All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	38	28	All SZGR 2.0 genes in this pathway
ERBB4信号中的Reactome SHC1事件	20	17	All SZGR 2.0 genes in this pathway
ERBB2信号中的Reactome PI3K事件	44	34	All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR SIGNALING BY ERBB4	38	30	All SZGR 2.0 genes in this pathway
Bertucci髓质与导管乳腺癌DN	169	118	All SZGR 2.0 genes in this pathway
Schuetz乳腺癌导管侵入性DN	84	53	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 UP	112	72	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
奥多内尔转移	82	58	All SZGR 2.0 genes in this pathway
Breuhahn生长因子信号传导肝癌	22	19	All SZGR 2.0 genes in this pathway
农民乳腺癌根源与基础	330	217	All SZGR 2.0 genes in this pathway
农民乳腺癌基础与仙女	330	215	All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR	62	33	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN	193	112	All SZGR 2.0 genes in this pathway
YANG乳腺癌ESR1 UP	36	22	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS	652	441	All SZGR 2.0 genes in this pathway
DING LUNG CANCER MUTATED SIGNIFICANTLY	26	22	All SZGR 2.0 genes in this pathway
弗莱赫纳活检肾脏移植被拒绝vs ok dn	546	351	All SZGR 2.0 genes in this pathway
Li Wilms肿瘤与胎儿肾脏1	182	119	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病	1691	1088	All SZGR 2.0 genes in this pathway
HNE和TBH的Weigel氧化应激	60	42	All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN	434	302	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1	528	324	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5	482	296	All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3	97	72	All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCERS KINOME BLUE	21	16	All SZGR 2.0 genes in this pathway
Massarweh tamoxifen抗性	578	341	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BRAIN DN	85	58	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP	172	109	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 UP	167	99	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN	134	83	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR DN	91	56	All SZGR 2.0 genes in this pathway
LIU TOPBP1目标	16	8	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	mirna seq
miRNA family	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
mir-101	7184	7190	1A	hsa-miR-101	uacaguacugauaacugaag
miR-125/351	6482	6488	M8	hsa-miR-125b^brain	ucccugagacccuaacuuguga
miR-125/351	6482	6488	M8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
mir-130/301	1080	1086	M8	hsa-miR-130a^brain	cagugcaauguaaaaggggau
				hsa-miR-301	cagugcaauaugucaaagc
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-135	5566	5573	1A，M8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
				hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
				hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
				hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-137	1140	1147	1A，M8	HSA-MIR-137	uauugcuuaagaauacgcguag
miR-138	1156	1162	1A	HSA-MIR-138^brain	AGCUGGUGUUGUGAAUC
miR-143	6806	6812	M8	HSA-MIR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-144	7184	7190	1A	HSA-MIR-144	UACAGUAUAGAUGAUGUACUAG
miR-146	7692	7699	1A，M8	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	7692	7699	1A，M8	hsa-miR-146b^brain	ugagaacugaauuccauaggcu
miR-19	1079	1085	M8	HSA-MIR-19A	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1079	1085	M8	HSA-MIR-19B	UGUGCAAAUCCAUGCAAAACUGA
miR-193	91	98	1A，M8	hsa-miR-193a	AACUGGCCUACAAAGUCCCAG
miR-193	91	98	1A，M8	hsa-miR-193b	aacuggcccucaaagucccgcuuu
miR-194	7825	7831	1A	HSA-MIR-194	uguaacagcaacuccauga
miR-199	1034	1041	1A，M8	HSA-MIR-199A	CCCAGUGUUCAGACUACCUGUUC
miR-199	1034	1041	1A，M8	HSA-MIR-199B	cccaguguuuagacuaucuuc
mir-205	7506	7513	1A，M8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
mir-221/222	6627	6634	1A，M8	hsa-miR-221^brain	agcuacauugucugugggggguc
mir-221/222	6627	6634	1A，M8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-23	7199	7206	1A，M8	HSA-MIR-23A^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	7199	7206	1A，M8	HSA-MIR-23B^brain	AUCACAUUGCCAGGGAUUACC
miR-24*	6253	6260	1A，M8	HSA-MIR-189	Gugccuacugagagauaucagu
miR-26	157	163	1A	HSA-MIR-26A^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	157	163	1A	HSA-MIR-26B^SZ	UUCAAGUAAUUCAGGAUAGGUU
mir-30-3p	178	184	M8	HSA-MIR-30A-3P	CUUUCAGUCGGAUGUUUGCAGC
mir-30-3p	178	184	M8	HSA-MIR-30E-3P	CUUUCAGUCGGAUGUUUACAGC
mir-323	7199	7205	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
mir-326	5021	5028	1A，M8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
mir-330	7266	7273	1A，M8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
mir-330	7266	7273	1A，M8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-362	7698	7704	M8	HSA-MIR-362	aauccuuggaaccuaggugugugugugugagu
miR-381	7325	7331	1A	HSA-MIR-381	UAUACAAGGGCAAGCUCUCUGU
miR-383	7782	7788	1A	HSA-MIR-383^brain	AGAUCAGAAGGUGAUUGUGGCU
miR-495	7823	7829	1A	HSA-MIR-495^brain	Aaacaaacauggugcacuuuuu
mir-543	7543	7549	1A	hsa-miR-543	aaacauucgcggugcacuucu
mir-543	7543	7549	1A	hsa-miR-543	aaacauucgcggugcacuucu
mir-7	73	79	M8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-93.hd/291-3p/294/295/302/372/373/520	1082	1088	1A	hsa-miR-93^brain	aaagugcuguucgugcagguag
				hsa-miR-302a	uaagugcuugcauguuuguga
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				HSA-MIR-372	AAAGUGCUGCGACAUUUGAGCGU
				HSA-MIR-373	Gaagugcuucgauuuggggugu
				HSA-MIR-520E	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	aaagugcuuuuuuagaggg
				hsa-miR-520c	aaagugcuuuuuuagagggUU
				hsa-miR-520d	aaaguguuugugggguggguu

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhere查看与大脑相关的miRNA列表。

Gene Page:嗯BB4